bone abnormalities Flashcards
1
Q
what are dysostoses?
A
bone diseases that result from anomalies in mesenchymal migration
usually limited to embryologic structures, mutations in homeobox transcription factors
more localized effects. i.e. failure of a bone to develop, extra bones, syndactyly
2
Q
what are dysplasias?
A
mutations in growth factors/receptors on collagen
global abnormalities, more widespread effects
3
Q
HoxD13 mutation causes:
A
extra digit between 3rd and fourth fingers with syndactyly
4
Q
senile osteoporosis
A
incomplete filling of osteoclast Howship’s lacunae
5
Q
what is alkaline phosphatase a measure of?
A
bone turnover/remodeling
alk phos attached to osteoblast surface via a PIG anchor
