body water tutorial

Question 1

what is the volume of distribution?

Answer 1

vd=dose/concentration in plasma

Question 2

if a drug moves out of the plasam is the Vd higher or lower?

Answer 2

higher (we can tell because the concentration in the plasma is lower)

Question 3

what is a low Vd?

Answer 3

0.3L/kg

Question 4

what drugs have a low Vd?

Answer 4

cephalosporins, aminoglycosides, NSAIDs

Question 5

what is a medium Vd?

Answer 5

0.3-1L/Kg

Question 6

what drugs have a medium Vd?

Answer 6

sulphas, florfenicol, phenobarbitol

Question 7

what is a high Vd?

Answer 7

> 1.0L/Kg

Question 8

what drugs have a high Vd?

Answer 8

coxibs, diazepam, fluoroquinolones, trimethoprim, tetracyclins, macrolides, chloramphenicol, metronidazole, rifampin

Question 9

is Vd constant for any drug?

Answer 9

yes, unless physiological or pathological changes occur (dehydration, diarrhea etc)

Question 10

change in body water affect what kind of drugs?

Answer 10

low Vd drugs

Question 11

changes in fat affect what kind of drugs?

Answer 11

high Vd drugs