Body Fluids Exam 2 Flashcards
This renal disease is caused by Group A Strep
Acute Glomerulonephritis
In what renal disease are RBC casts a “defining” finding?
Acute Glomerulonephritis
What is shown in these photos? What disease correlates with finding these in the sediment?

- RBC casts
- Acute Glomerulonephritis
How do RBCs differ from yeast in appearance?
Yeast typically has buds
Fatty urine is a sign of what renal disease?
Nephrotic syndrome
This renal disease is a complication of other renal diseases or systemic shock
Nephrotic syndrome
In Nephrotic Syndrome, a loss in _____ ______ triggers fat production and fats then leak through and end up in the urine.
Serum protein
A diabetic patient is admitted with oliguria and swelling of the hands and ankles.
Their urine is yellow, turbid, and foamy.
Dipstick results are as follows: Protein is 4+, Blood is Moderate, Trace Glucose, Moderate LE.
Microscopic reveals 20-30 RBC/hpf, 25-30 WBC/hpf, Many RTEs, 0-2 fatty casts/lpf, and few oval fat bodies.
What is probable diagnosis?
Nephrotic syndrome
What crystals might you see in a patient with nephrotic syndrome?
Cholesteral crystals
This renal disease is typicall due to severe infection but can also result because of shock or toxins.
Acute tubular necrosis
In what renal disease might you see RTE casts?
Acute tubular necrosis
This urinary tract infection my have WBC casts seen in the microscopic. Dipstick results would include LE+ and Nitrite +/-.
Pyelonephritis
This UTI is considered a lower UTI. You will NOT see WBC casts. LE+, Nitrite +/-, bacteria, protein and some blood are all possibilities.
Cystitis
This renal disease can be either acute or chronic. Possible casts seen in microscopic include: RTE, granular, waxy, and broad. Symptoms include: acid-base imbalances, increased urea (possible cause of psychosis), and decreased erythropoietin (causing anemia).
Renal failure
If the kidneys are unable to excrete acids, this can occur.
Renal tubular acidosis
In renal tubular acidosis, _______ pH is low while _______ pH is high.
Blood pH is low while urine pH is high
What is performed on infants 3-5 days after birth?
Newborn Screening Tests
What are the newborn screening tests looking for?
- Errors in metabolism
- Endocrinopathies
- Cystic fibrosis
- Hemoglobinopathies
What microorganism is sometimes the cause of glomerulonephritis in children?
Group A strep
When red cells are allowed to sit in a hypotonic environment, what can happen to them?
Ghost cells
If red cells are allowed to sit in a hypertonic environment, what can happen to them?
Crenation
Normal range for RBCs in a urine microscopic
< 2/hpf
Normal range of WBCs in a urine microscopic
0-5/hpf
What is the typical WBC seen in urine?
Segmented neutrophils
When are lymphocytes seen in urine?
Inflammation due to kidney rejection
Term for presence of WBCs in urine
Pyuria
Term for inflammation of the bladder
Cystitis
Term for inflammation of the urethra
Urethritis
Term for kidney infection
Pyelonephritis
When WBCs are allowed to sit in a hypotonic environment, what can happen?
Glitter cells
What would you expect the pH to be (acidic or alkaline) if both bacteria and WBCs are present in the urine?
Alkaline
These are considered a vaginal contaminant and typically indicative of bacterial vaginosis due to Gardnerella vaginalis
Clue cells
These epithelial cells are associated with the lower urinary tract
Squamous epithelial
What epithelial cells are associated with bladder and ureters?
Transitional epithelials
These epithelials are typically seen with bladder infections and catheterized urine.
Transitional epithelials
These epithelials are associated with the kidneys. Seeing >2/hpf is considered significant
Renal tubular epithelials
What phenomenon occurs when WBCs are allowed to sit in a hypotonic urine?
Glitter cells
These epithelials typically have a central nucleus and may be pear shaped or caudated
Transitional epithelials
What renal disease are oval fat bodies typically associated with?
Nephrotic syndrome
What stains are used for oval fat bodies?
Sudan or Oil Red O
What could cause a positive nitrite with negative LE?
Improper specimen storage
What would cause a positive nitrite and positive LE?
Infection
What is the protein matrix made up of in casts?
Tamm-Horsfall
This type of cast can be caused due to dehydration, exercise, stress, or fever. It is the least significant cast.
Hyaline cast
This cast is always significant when seen and may be seen because of infections, malignancies, HUS, or SLE.
Red blood cell cast
This cast type is seen with lower UTIs and pyelonephritis.
White blood cell cast
This cast is a sign of advanced tubular necrosis.
Epithelial cell cast
This cast occurs due to nephrotic syndrome, crush injuries, or diabetes. You may see oval fat bodies and cholesterol crystals with it.
Fatty cast
This cast is seen with exercise, stress, fever, or dehydration. It is caused by a variety of renal diseases.
Granular cast
What cast indicates extreme urine stasis, renal failure, or chronic renal disease?
Waxy cast
What cast forms in the collecting ducts?
Broad cast
What are the normal crystals found in acidic urine?
- Amorphous urates
- Uric acid
- Calcium oxalate
These crystals precipitate upon cooling and dissolve by warming
Amorphous urates
This crystal type is seen in patients with gout or chemotherapy patients
Uric acid
Crystals:
Small square envelopes
Calcium oxalate
The oval form of this crystal is found in patients with ethylene glycol poisoning
Calcium oxalate monohydrate
What are the normal crystals found in alkaline urine?
(5)
- Amorphous phosphate
- Triple phosphate
- Calcium phosphate
- Ammonium biurate
- Calcium carbonate
These crystals are found in alkaline urine and will not dissolve upon warming.
Amorphous phosphates
Crystals:
Look like coffin lids and are often seen in UTIs
Triple phosphates
Crystals:
Prisms or rosettes
“Shards of glass”
Calcium phosphates
Crystals:
“Thorny apples” found in old urine or UTIs that are brownish in color
Ammonium biurate
Crystals:
Small dumbells found in alkaline urine
Calcium carbonate
What are the abnormal crystals found in urine?
(7)
- Cystine
- Tyrosine
- Leucine
- Bilirubin
- Cholesterol
- Radiographic dye
- Drugs
Crystals:
- “Stop signs”
- Due to a reabsorption defect
- Causes kidney stones at a young age
Cystine
Crystals:
- Brown to black fine needles
- Caused by severe liver disease in adults
- Caused by impaired amino acid metabolism in children
Tyrosine
Crystals:
- “Wagon wheel”
- Due to sever liver disease in adults
- Maple syrup urine disease in children
Leucine
Crystals:
-Icteric needles caused by hepatitis and other liver diseases
Bilirubin crystals
Crystals:
- Notched corners
- Seen with nephrotic syndrome
Cholesterol crystals
Crystals:
- Resemble tyrosine crystals but are thicker.
- Concerned with dehydration
Radiographic dye crystals
Crystals:
- Can be caused by antibiotics or sulfa drugs
- Can damage tubules
- Check patient hydration
-Drug crystals
Crystals:
- pH of 5.5
- Dissolved after being warmed

Amorphous urates
Crystals:
- acidic pH
- Gout and chemo patients

Uric acid
Crystals:
-acidic to neutral pH

Calcium oxalate
Crystals:
-Ethylene glycol poisoning

Calcium oxalate monohydrate
Crystals:
- Alkaline pH
- Remains after warming sample

Amorphous phosphates
Crystals:
- Often seen in UTIs
- Alkaline pH

Triple phosphates
Crystals:
“Shards of glass”
-Prisms or rosettes

Calcium phosphates
Crystals:
“thorny apples”
seen in old urine and UTIs

Ammonium biurate
Crystals:
-Small dumbbells

Calcium carbonate
Crystals:
-Can cause kidney stones at a young age

Cystine
Crystals:
- Severe liver disease in adults
- Impaired amino acid metabolism in chilren

Tyrosine
Crystals:
- Maple syrup disease in children
- Severe liver disease in adults

Leucine
Crystals:
Dipstick: bilirubin +

Bilirubin crystals
Crystals:
- Nephrotic syndrome
- notched corners

Cholesterol crystals
Crystals:
- Concerned for patient dehydration
- High SG with refractometer

Radiographic dye crystals
Crystals:
- Antibiotics or sulfa drugs
- Can damage tubules

Drug crystals
Term:
Decreased urination
Oliguria
Term:
Increased urination
Polyuria
Term:
No urination
Anuria
Term:
Increased urination at night
Nocturia
Term:
Painful urination
Dysuria
Term:
WBCs in urine
Pyuria
With diabetes insipidus, _______ causes an increase in plasma osmolality.
Sodium
With diabetes mellitus, _______ is causing an increase in plasma osmolality.
Glucose
In diabetes mellitus, there is a decreased production or function of what?
Insulin
In diabetes insipidus, there is a decreased production or function of what?
Anti-diuretic Hormone
aka
Vasopressin
SG Diabetes:
Diabetes insipidus has a _____ SG, Diabetes mellitus has a _____ SG.
Insipidus: Low SG
Mellitus: High SG