BM - Smoking, alcohol and substance abuse Flashcards

1
Q

What is drug addiction?

A

Chronic condition characterised by compulsive drug seeking and use, despite harmful consequences.

This applies to all drugs, not just smoking and alcohol.

7000 people die every year directly because of alcohol.

Nearly 1 million people die each year directly because of smoking.

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2
Q

What is ‘addiction’ in terms of DSM-5?

A

Addiction” is not a specific diagnosis in the (DSM-5)–(APA)

DSM-5 replaced substance abuse and substance dependence with: substance use disorder. Associated symptoms of substance use disorder: impaired control, social impairment, risky use, and pharmacological criteria (tolerance and withdrawal).

DSM-5 is a list of conditions which contribute to mental disorders.

This definition introduces tolerance and withdrawal which are heavily biological.

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3
Q

What does DSM say about addiction?

A

DSM describes pattern of use of an intoxicating substance leading to clinically significant distress, manifested by at least two of the following, occurring within a 12-month period:
- Substance often taken in larger amounts or over a longer period than interested
- Persistent desire or unsuccessful effort to cut down or control use of the substance
- A great deal of time spent in activities to obtain the substance, use the substance, or recover from it’s effects
- Craving/strong desire to use substance
- Recurrent use resulting in failure to fulfil work, school or home obligations
- Continued substance use despite persistent/recurrent social or interpersonal problems caused or exacerbated by use
- Important social, occupational, or recreational activities are given up/reduced due to substance use
- Recurrent substance use in situations where it is physically hazardous
Continued substance use despite having a persistent or recurrent physical or psychological problem that is likely to have been caused/exacerbated by substance use

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4
Q

How many people want to stop smoking?

A

70% o people who regularly smoke don’t want to.

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5
Q

What is tolerance?

A

Tolerance, defined by either of the following:
- Need for increased amounts of the substance to achieve intoxication or desired effect
A markedly diminished effect with continued use of the same amount of the substance

We know that tolerance is environmentally conditioned. Biologically when you’re in a specific pub you recognise the environment but then if you went somewhere else, had a different alcohol in a different place you would have a lower tolerance.

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6
Q

What is withdrawal?

A

Withdrawal, either of the following:

The characteristic withdrawal syndrome for that substance (see DSM-5)

The substance (or related substance) taken to relieve/avoid withdrawal symptoms

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7
Q

What is the history of smoking?

A

• 1492 Columbus discovers tobacco in the New World
• 16th Century – Pipe Smoking in England began
• 1610 Sir Francis Bacon writes that tobacco use is increasing and is a custom hard to quit
• 1693 Smoking is banned in the House of Commons chamber
• 1761 London Physician John Hill does a clinical study of tobacco effects
• 1791 Cases of snuff caused nasal cancers reported by John Hill
• 1889 – Research by Langley & Dickenson on the effect of nicotine upon nerve cells
• 1912 1st strong connection between is made between smoking and lung cancer
• 1930 – 1st statistical correlation made between cancer and smoking
• 1939 –” Tobacco Misuse and Lung Carcinoma” by Franz Hermann Muller of the University of Cologne is published.
• 1951 – 1st epidemiological study showing association between smoking and lung cancer
• 1962 Royal College of Physicians 1st report on “Smoking & Health”
• 1978 – BMJ article: passive smoking is harmful to health
• 1988 – BMJ editorial & article on the link between smoking and leukemia
• 1998 – Government White Paper published on tobacco control
• 1998 EU directive to ban tobacco advertising and sponsorship
• 2004 – Ireland – first country in the world to ban smoking in workplaces & public places
• 2007 – Smoking Ban brought in UK
• 2008 – Smoking ban applies to mental health settings
2015 – Smoking banned in cars with anyone under 18 present

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8
Q

Some smoking facts…

A

Although cancer was found to be associated with smoking at early as 1791, it couldn’t be proved as the only way to do this is through an experiment (forcing some to smoke and other not - unethical). Therefore could only be viewed as a correlation rather than causation.

2007 ban most effective intervention to date.

> 85% of people with a mental health problem smoke (as opposed to around 20% of the general population). Much of this is a form of self-medication.

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9
Q

WHO tobacco facts…

A
  • Tobacco is one of the biggest public health threats.
  • Over one billion smokers in the world
  • Globally, use of tobacco products is increasing, although it is decreasing in high-income countries
  • Nearly half the world’s children breathe air polluted by tobacco
  • The epidemic is shifting to the developing world
  • Over 80% of the world’s smokers live in low and middle income countries.
  • Tobacco use kills 5.4 million people a year
  • Tobacco kills up to half of all users
  • It is a risk factor for six of the eight leading causes of death in the world
  • 100 million deaths were caused by tobacco in the 20th century.
  • Unchecked, tobacco- related deaths will increase to more than eight million by the year 2030, and 80% of those deaths will occur in the developing world

50% of regular smokers will die of direct causes from the smoking.

1 in 2 individuals will develop cancer at some point in their lives. Adding on negative health choices elevate the risk.

As treatments get better, it actually increases the numbers of people who undertake the bad health behaviour, because it is less worrying to them.

Heroine is normally most addictive drug in the world, very very closely followed by nicotine (almost the same).

A packet of cigarettes costs between 1-2p to make!! Make a huuuggeeee profit!

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10
Q

What is the global prevalence of smoking?

A

WHO statistics

• Almost 1 billion men in the world smoke cigarettes, about 35% of men in developed (but decreasing rapidly!) and 50% in developing countries.
• Around 250 million women in the world smoke cigarettes, about 22% in developed (also decreasing rapidly) and 9% in developing countries.
• Global smoking prevalence has hit a peak, and is declining in the more wealthy countries but in poorer, developing countries smoking is increasing.
Tobacco will kill over 175 million people worldwide between now and the year 2030

The less money you have, the more you smoke generally

social norms are hugely strong in encouraging people to take up negative behaviours

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11
Q

Tobacco facts europe

A

• Tobacco is the single largest cause of avoidable death in the EU
• Tobacco accounts for over a million deaths in Europe as whole.
• Estimated that 25% of all deaths in the Union could be attributed to smoking
The EU is actively developing a tobacco control policy.

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12
Q

What is the current UK prevalence of smoking?

A

• There are currently estimated to be 10 million smokers in Great Britain.
• This equates to 20% of men and 17% of women
Smoking prevalence is highest in the 20-24 age group for both men and women (32% and 30% respectively) but thereafter in older age groups the proportion of smokers declines.

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13
Q

Smoking in adults over 16 in England 2006

A
  • results from the General Household Survey show, overall smoking prevalence has decreased. In 2006, 22 per cent of adults reported smoking, compared to 24 per cent in 2005 and 39 per cent in 1980
  • as with previous years, smoking was higher among men than women (23 per cent and 21 per cent respectively) although this gap is narrowing
  • those in the routine and manual groups reported the highest prevalence of smoking (29 per cent)
  • there has been a marked increase in the proportion of smokers who smoke mainly hand-rolled tobacco. In 1990, 18 per cent of men and two per cent of women who smoked said they smoked mainly hand-rolled cigarettes, but by 2006 this had risen to 34 per cent and 17 per cent respectively
  • current smokers smoked an average of 13.5 cigarettes a day

Very resistant to change behaviour - even if doubled the price of a packet only would drop by 10% tomorrow.

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14
Q

Smoking among adults in GB in 2007

A

Among adults
• two-thirds (67 per cent) of adults report that they do not allow smoking at all in their home, an increase from 61 per cent in 2006
• four in five people agree with the smoking ban in public places

And almost 8 in 10 current smokers reported trying to give up smoking at some point in the past

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15
Q

Smoking effects in England in adults 35 and over in 2006-07

A

In England in 2006/o7 among adults aged 35 and over:

445,100 hospital admissions are estimated to be attributable to smoking. This accounts for 5% of all hospital admissions among this age group. Around a quarter 26 per cent (107,600) of all admissions with a primary diagnosis of respiratory diseases, 16 per cent (139,600) of all admissions with a primary diagnosis of circulatory diseases and 13 per cent (163,200) of all admissions with a primary diagnosis of cancer are attributable to smoking

In England in 2007 among adults aged 35 and over:

82,900 deaths (18 per cent of all deaths of adults aged 35 and over) were estimated to be caused by smoking with a larger proportion of men (23 per cent) estimated to die from smoking-related diseases than women (14 per cent)

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16
Q

Smoking in england in children 11-15

A

Two-thirds of pupils reported they had never smoked. The proportion who had never smoked rose from 47% in 1982 to 67% in 2007

Six per cent of children reported that they were regular smokers (smoked at least once a week)

Regular smokers smoked on average 6 cigarettes a day

Girls were more likely to have ever smoked than boys (36% compared to 31%) and to smoke regularly (8% compared with 5%)

Since 1990 there has been an increase in the number of pupils being refused cigarettes at point of sale, from 37% in 1990 to 53% in 2006

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17
Q

Why do people smoke?

A

Despite the impact on health, people continue to smoke – why?

Smoking is a highly addictive substance

“Cigarettes are highly efficient nicotine delivery devices and are as addictive as drugs such as heroin or cocaine.” Royal College of Physicians, 2000.

View that adults smoke to cope with life- personal reasons

Children/adolescents smoking is motivated by attempts to achieve the status of cool and hard, and to gain group membership –social reasons.

Young people – way of rebelling or getting at those in authority
Myths – re loss of weight, relaxing etc

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18
Q

What does smoking do to your body?

A
nose cancer
mouth cancer
coughing and sneezing
shortness of breath
lung cancer
leukaemia
bronchitis and emphysema
kidney cancer
bladder cancer
fertility affected
gangrene
stroke
defective vision
larynx cancer
throat cancer
oesophagus cancer
aortic aneurysm
CHD
stomach cancer
peptic ulver
pancreas cancer
peripheral vascular disease
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19
Q

Smoking’s impact on health

A
  • Smoking harms nearly every organ of the body, causes many diseases, reduces quality of life and life expectancy
  • The most recent estimates show that around 114,000 people in the UK are killed by smoking every year, accounting for one fifth of all UK deaths (Peto et al). Half of all smokers will be killed by their habit.
  • The three main diseases associated with cigarette smoking and death are: lung cancer, chronic obstructive lung disease (bronchitis and emphysema) and coronary heart disease.
  • It is estimated that between 1950 and 2000 six million Britons, 60 million people worldwide, died from tobacco-related diseases
  • Half of all teenagers who are currently smoking will die from diseases caused by tobacco if they continue to smoke. One quarter will die after 70 years of age and one quarter before, with those dying before 70 losing on average 21 years of life.
  • Risk of dying from lung cancer is 22X higher among men who smoke
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20
Q

Second hand smoke

A
  • People that breath secondhand smoke are at risk of the same diseases as smokers, including cancer and heart disease, because secondhand smoke contains 4,000 toxic chemicals. It is estimated that secondhand smoke causes thousands of deaths each year.
  • Children are particularly affected by secondhand smoke because their bodies are still developing, and around half of all British children are growing up in homes where at least one parent is a smoker.
  • Smoke in the air contains about 4,000 chemicals
  • Over 50 of these chemicals are carcinogens: they cause cancer. and also contribute directly to other diseases, such as asthma, heart disease and emphysema.
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21
Q

Mortality in relation to smoking

A

Dell et al 2004 (BMJ, 328)

  • Longitudinal study of UK male doctors who smoke - studied for 50yrs
  • Recorded all deaths for 50 years (1951-2000)
  • Smokers on average lose 10 years of life
  • Stopping smoking works, stopping smoking at age 35-44 gains about 9 years of life
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22
Q

scenarios for future deaths from tobacco…

A

increasing at an increasing rate towards 2050

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23
Q

smoking prevalence and mental health

A

• Psychiatric patients are twice as likely to smoke as general population (El-Guebaly & Hodgins, 1992).
• 45% of all cigarettes smoked by individuals with a psychiatric disorder (Lasser et al. 2000)
• While general smoking rates are falling – not so among psychiatric populations (McCloughen, 2003).
• Mental health: smoking, treatment and going smoke free
Eden Evins, Director, Addiction Research Program, Massachusetts General Hospital & Assistant Professor of Psychiatry, Harvard Medical School, Boston, USA

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24
Q

smoking prevalence and mental health issues in order….

A

(in increasing order)
generalised anxiety
depression
psychosis

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25
Q

why do psychiatric patients smoke so much?

A
  • There are several theories concerning the higher rates of smoking among mental health patients:
  • Self medication (eg: effects on neurotransmitters of nicotine) (Le Houezac, 1998)
  • Mediating role of social deprivation (Jarvis & Wardle, 1999).
26
Q

About smoking legislation…

A
  • White Paper DH, 1998 Statement of Government Policy
  • Health Act 2006 and five sets of smokefree regulations set out the detail of the smokefree legislation
  • Smoking ,Health and Social Care (Scotland) Act 2005 – implemented March 2006
  • The Smoke-free Premises (Wales) Regulations 2007 implemented April 2007
  • The Smoking (Northern Ireland) Order 2006 implemented April 2007
  • Sale of tobacco products to under 18s illegal from Oct 2007
  • 1 October 2015 – Smoking banned in cars with anyone under 18 years in them
27
Q

What is the value of cessation - public health gains?

A

500 million will die from smoking related disease world wide in the first half
of the 21st Century

A study of half a million adults concludes that quitting smoking lowers your risk of dying from lung cancer by 70 percent, researchers say.

28
Q

what has greater impact - prevention or cessation?

A

cessation

29
Q

UK smoking cessation facts…

A
  • 680,289 people set a quit date through the NHS Stop Smoking Services, an increase of 13% since 2006/07
  • At the 4 week follow-up 350,800 people had successfully quit (based on self-report), 52% of those setting a quit date. This compares with 319,720 successful quitters in 2006/07 (an increase of 10%)
  • More women than men set a quit date in 2007/08 (373,000 compared with 307,289) and more women than men successfully quit (188,708 compared with 162,092), although the success rate of giving up smoking was slightly higher among men than women (53% and 51% respectively)
  • Of those setting a quit date, success rates generally increased with age, from 38% of those aged under 18, to 60% of those aged 60 and over
  • People from ethnic minority groups accounted for 3% of those setting a quit date in 2001/02 (7,366), compared to 6% in 2007/08 (37,734)
  • The success rate of giving up smoking was highest among those in the Mixed and White ethnic groups (52% and 51% respectively) and lowest among those in the Black and Black British group (45%)
  • Of the 18,977 pregnant women who set a quit date, 9,817 successfully quit (52%)
  • The majority of those setting a quit date received Nicotine Replacement Therapy (NRT) only (70%). A further 14% received varenicline (Champix) only, 3% received bupropion (Zyban) only and less than 1% received both NRT and bupropion. Six per cent of people setting a quit date did not receive any pharmacotherapy and the type of treatment was unknown for a further 6%
  • Varenicline was the most successful pharmacotherapy in helping people quit. Of those who used varenicline 63% successfully quit, compared with 53% who received bupropion only, and 49% who received NRT. Fifty-five per cent of people who did not receive any type of pharmacotherapy successfully quit
  • Expenditure on NHS Stop Smoking Services was almost £61 million in 2007/08 nearly £10 million higher than in 2006/07 and almost £36 million more than expenditure in 2001/02. The cost per quitter was £173 in 2007/08. This has increased by 8% since 2006/07 but is down overall since 2001/02 when the cost per quitter was £206
30
Q

What is the concept of addiction… definitions?

A
  • Definitions of addiction – difficult to define, anabstract concept that is socially defined
  • Medical – “dependence on a drug, resulting in tolerance and withdrawal symptoms when the addict is deprived of the drug (Rosenhan & Sleigman, 1989)
  • Psychological – “an attachment to an appetitive activity, so strong that a person finds it difficult to moderate the activity despite the fact that it is causing harm (p.18) (Orford, 2001)
31
Q

Tobacco addiction…

A

Smoking is a complex behaviour that can be thought of in two ways:

- Pharmacological
- Psychological
32
Q

What is the medical approach to smoking addiction?

A
  • Medical approach adopts biological explanations of addictive behaviour, and focus on neurotransmitter substances in the brain and genetic differences.
  • Nicotine is the active ingredient in tobacco smoke. Nicotine affects a number of physiological systems including learning and memory, the control of pain, anxiety relief. Its effects include tranquilisation, weight loss, decreased irritability, increased alertness, and improved cognitive functioning
  • Tolerance and physical dependence occur rapidly
  • One reason nicotine is highly addictive because it activates brain circuits that regulate feelings of pleasure and euphoria – dopamine pathway
  • Nicotine mimics the action of the neurotransmitter acetylcholine, which plays a role in stimulating other neurons to release their neurotransmitters eg dopamine neurons.
  • The acute effects of nicotine disappear in a few minutes, causing the smoker to want to experience the feeling again, and renders them susceptible to addiction to maintain pleasurable effects and prevent withdrawal symptoms

From stopping, it takes 48 hours for all nicotine to be out of the body system, however craving persist for years.

33
Q

About nicotine withdrawal…

A
  • Smoking tobacco regularly leads to the individual becoming tolerant, and in need of nicotine to function normally
  • If nicotine is withdrawn from the body in an addicted individual, craving occurs and withdrawal symptoms including irritability, anxiety, insomnia, depression, poor concentration may occur
  • Smoking at this stage removes withdrawal symptoms, however because of the action of nicotine on Ach, it only serves to overcome the feeling of restlessness that it caused in the first place.
34
Q

The biological theories of smoking…

A
  • Genetic links in the risk of smoking
  • Genetic factors increase the likelihood of smoking initiation and maintenance
  • GF accounted for 50% of the risk of smoking
  • Environment accounted for 30%
35
Q

Psychosocial approaches to smoking addiction

A
  • Smoking is more than just a chemical addiction. Other processes are involved
  • Psychosocial components of smoking cessation work is often underpinned by a relevant theoretical perspective
  • Therapies and the theories that inform them are not mutually exclusive. There is overlap and cessation work may involve a synthesis of various approaches.
36
Q

Stage of change…

A

Work in the area of smoking has often focussed on how cognitions and behaviours may differ according to the ‘stage’ an individual is at in the process of quitting (Prochaska and DiClemente, 1982)

• Movement is not always in one direction. Individuals, when quitting, may move back through the changes (eg relapse) as well as forward
• This model informs the focus of cessation therapy eg on health risks of cessation techniques
The model has proved valuable in predicting the success of smoking interventions (DiClemente et al 1991)

37
Q

What is the transtheoretical model?

A
Pre contemplation
contemplation
Preparation
Action
Maintenance
Relapse can come from any of these
38
Q

What are the psychological theories with stopping smoking?

A
• Learning theory
• Affect  management (Tomkins 1966)
· Reduction of negative affect
	- Habit
	- Addiction
	- Pleasure
	- Stimulation
	- Sensorimotor manipulation (Ikard et al 1969)
· Sensation-seeking (Zuckerman, 1979)
· Extraversion
· Stress
· Personality
39
Q

What is the psychosocial model of smoking?

A
  • Smoking is a social activity
  • Social meanings of smoking determine smoking maintenance
  • Smoking is part of the biocultural demands of late modernity - an efficient mood-control tool in a rapidly changing lifestyle
40
Q

How can we assess and intervene with smokers?

A

Social Environment

  • social disorganisation
  • inadequate socialisation
  • role strain

Social bonding
- personality, peer, school

Social learning
- observation
- opportunity
- social norms
- reinforcement
(intrapsychic)
- skills
- self-efficacy
- self-esteem
- stress
- distress

KAB
knowledge-attitude-behaviour

41
Q

Assessing and intervening with smokers - assessment

A
  • Over two thirds of smokers want to stop and about one third try to stop in any year
  • The unaided cessation rate in middle aged smokers is only about 2% per annum, making nicotine one of the most addictive drug of all (Royal College of Physicians, 2000)
  • It can be helpful in the clinical setting to assess nicotine dependence, which might help a clinician decide which treatment approach is most suitable
  • The Fagerstrom Test of nicotine dependence is the standard instrument used to assess the severity of nicotine addiction
  • Additional questions can be used to determine the patient’s readiness to change and the nature of the reinforcement the patient receives from smoking
42
Q

What is an example of a test for dependence?

A

Fagerstrom test of nicotine dependence

43
Q

NRT

A
  • Nicotine is a drug with a range of effects that can be positively reinforcing.
  • Withdrawal leads to a range of adverse effects.
  • In supporting smoking cessation efforts, Nicotine Replacement Therapy is an important supplement.
  • Use of NRT greatly enhances the success of all smoking cessation therapies.
44
Q

Bupropion (Zyban)

A
  • Zyban is an atypical antidepressant.
  • Although it is effective in reducing major withdrawal symptoms it does not work for everyone.
  • Zyban may interact with other medications and produce adverse effects.
45
Q

Brief intervention in primary care…

A
  • GPs and other primary care professionals play a crucial role by initiating and motivating quit attempts.
  • Promote stop smoking services; provide services & signpost to services
  • GPs can help patients quit smoking by giving them brief advice and a prescription for NRT or Zyban if appropriate, and refer to specialist smoking cessation clinics for more intensive support if its needed.
46
Q

What are some other settings for interventions?

A
  • Pharmacy services
  • Workplace interventions
  • Local authorities
  • School based services
  • Public campaigns eg No Smoking Day- national
  • World No Tobacco Day- international
47
Q

What is a way of psychological therapies for addiction?

A

Motivational Interviewing (MI)

  • Major intervention used in smoking cessation work in clinical settings
  • MI is a structured talking therapy involving directive counselling
  • Its technique is to recognise and overcome ambivalence
  • Gentle art of changing attitude (Rollnick & Miller (1995)
  • Involves assessing readiness to change, so uses principles from stage of change model
48
Q

How well does treatment work?

A
  • NRT and Zyban roughly double the chances of success in stopping smoking. Behavioural support significantly increases the chances of success; more support leads to higher cessation rates.
  • Brief routine advice from a GP leads to about 40% attempting to stop and about 5% stopping for at least six months
  • Face to face behavioural support from a cessation specialist enables about 10% to succeed long term.
49
Q

Facts about alcohol

A

• First reported evidence of alcohol comes from China roughly 9000 years ago.
• It is now widely consumed in most countries.
• Only requirement is sugar and appropriate conditions for fermentation
• Common among ancient civilisations of Egypt, Mesopotamia, Greece and Rome
• Dangers of abuse recognised early
• Problems increased with introduction of distillation:
• Middle East 9th to 10th century
• Europe 13th century
○ Brandy used mainly for medicinal purposes
• Expense limited use
• Increased prevalence with the introduction of Gin

50
Q

About standard drinks

A
  • Alcohol consumption is usually measured in units.
  • One unit equals 10ml pure alcohol, which is equivalent to:
  • Half a pint of ordinary strength beer
  • A very small glass of wine
  • A single pub measure of spirits (25ml)
  • A glass of sherry or other fortified wine (50ml)
51
Q

What are the effects of alcohol on the CNS?

A

• Depressant actions
• Actions depend on effects on specific ion channels and receptors
• Main theories
• enhancement of GABA-mediated inhibition
• inhibition of calcium entry through voltage-gated calcium channels
• inhibition of NMDA-receptor activation
Some evidence for enhancement of excitatory effects produced by activation of nicotinic acetylcholine receptors

52
Q

What are the acute effects of alcohol?

A
  • Slurred speech
  • Reduced intellectual and motor performance
  • Reduced sensory discrimination
  • Increased self-confidence
  • Varied mood effects
    • Due to psychological and social setting
    • More unstable at higher levels of intoxication
  • Relationship with plasma ethanol concentration is variable
    • Given concentration produces larger effect when concentration is rising
53
Q

What are the chronic effects of alcohol?

A
• Primary chronic effects
	• Neurological 
	• Liver
	• Cardio vascular
• Other chronic effects
	• High mortality
	• Cancers
		○ difficult to separate from smoking
• Gastric disorders
• Endocrine changes
	• hypogonadism & feminisation
54
Q

What are the chronic neurological effects of alcohol?

A

• Dysfunction occurs along a continuum
• Due to lifestyle and direct toxic effects of ethanol and metabolites
Wernicke-Korsakoff syndrome
• Distinct brain lesions associated with
• irreversible and severe memory impairment
• ataxia and ocular problems
• general confusion
• Main cause
• thiamine deficiency thought to be main cause
• direct toxic effects on CNS may contribute

55
Q

What are the chronic effects of alcohol on the liver?

A
  • Fat accumulation
    • increased release of fatty acids
    • impaired fatty acid oxidation due to metabolic load of ethanol
  • Increased fat accumulation leads to hepatitis (inflammation of liver) eventually leads to irreversible necrosis and fibrosis
  • Increased bleeding in liver
  • A direct toxic effect of ethanol, although other factors are also important
    • malnutrition, thiamine deficiency, cellular toxicity
56
Q

What are the chronic effects of alcohol on lipid metabolism and platelet function?

A
  • Moderate drinking shown to reduce mortality associated with coronary heart disease
  • Around 2 drinks per day with non-drinking days
  • Function of ethanol itself
  • Two possible mechanisms
    • increased plasma lipoproteins
    • inhibited platelet aggregation
57
Q

What is physical dependence on alcohol?

A
  • Well-defined withdrawal syndrome
    • severe form develops after approx. 8hrs
  • First stage
    • lasts 24-hours: tremor, nausea, sweating, fever
  • Second Stage
    • lasts several days: tonic convulsions & delirium tremens
  • In absence of serious medical complications, withdrawal syndrome is self-limiting
  • Psychological dependence is more difficult to treat
58
Q

What are the pharmacological treatment options for alcohol misuse?

A

Alleviate acute withdrawal symptoms: clonidine, benzodiazepines

Long-term substitute for abused drug: none

Block acute positive rewarding effect: naltrexone, disulfirum

Diminish craving: acamprosate

Treatment goals:

- Provide symptomatic relief
- Prevent withdrawal complications
- Facilitate post-withdrawal treatment
59
Q

What is post withdrawal antabuse?

A

DISULFIRAM

  • Block acute positive rewarding effect : Inhibits aldehyde dehyrogenase leading to increased acetylaldehyde
    • In presence of alcohol produces uncomfortable acetylaldehyde reaction
    • Fear of this reaction usually prevents drinking
  • Clinical Trials
    • results mixed - poor on relapse but does reduce drinking days
    • highly motivated patients willing to adhere and without heart, liver or renal disease
60
Q

Naltrexone

A
  • Block acute positive rewarding effect
  • Oral opioid antagonist
    • affinity for all opioid receptors
  • Mechanism unclear
    • possibly due to block of endogenous opioids, which may be involved in rewarding effects of alcohol
  • Clinical trials
    • good evidence for reducing relapse and number of drinking days
    • some evidence that it reduces craving
61
Q

Campral (acamprosate calcium)

A
  • Diminish craving: Mechanism of action
    • unclear
    • chemical structure similar to GABA
  • Possibly restoration of normal activity of GABA & glutamate systems
    • activation of GABAA receptor & blockade of NMDA receptor
    • Animal studies (increase GABA uptake sites and GABA transmission)
  • Clinical Trials
    • good evidence enhances abstinence and reduces drinking days
62
Q

What are psychological treatment options for alcohol misuse?

A
  • 12 Step programs
  • Counselling/psychotherapy
  • Social support