Blood unit vocab deck 1 Flashcards
color of blood
arterial blood is bright red; venous blood- dark red
connective tissue
blood is a type of connective tissue
matrix
extracellular substance in connective tissue
fibers-fibrin threads
produced by fibroblasts
plasma
liquid part of blood, contains clotting factors
serum (s), sera (pl)
liquid part of blood without clotting factors
formed elements
white blood cells, red blood cells, platelets
red bone marrow
where blood cells are made
yellow bone marrow
marrow that is fat
hematopoiesis
the forming of blood cells, takes place in red bone marrow
differentiation/differentiated cells
cells becoming specialized/ specialized cells
stem cells
unprogrammed, undifferentiated cells
hemocytoblasts
partially programmed cells in red bone marrow
erythrocytes
red blood cells
biconcave
describes the shape of a mature RBC
anucleate
lacking a nucleus, mature RBCs are anucleate
hemoglobin
found in RBCs, carries oxygen
adenosine triphospahte
ATP, usable energy source
cellular respiration
process that takes food and converts it into ATP
anaerobic
cellular respiration without oxygen
aerobic
cellular respiration with oxygen
oxygen
needed for aerobic cell respiration
carbon dioxide
a waste of cellular respiration
leukocytes
white blood cells
wright’s stain
used to stain blood smears for WBC differentials
diapedesis
the passage of certain WBCs through capillary walls
B cells
a type of lymphoctye that produces antibodies
Functions of Blood; distribution
blood transports oxygen from the lungs and nutrients from the digestive tract, metabolic wastes from cells to the lungs and kidneys for elimination and hormones from endocrine glands to target organs.
blood is the body’s only_____
tissue fluid.
Blood is composed of
liquid plasma &; formed elements
Formed elements include
erythrocytes, leukocytes and platelets.
hematocrit (or packed cell volume PCV)
a blood test that measures the % of the volume of whole blood that is made of RBC ; the percentage of red blood cells out of the total blood volume, depends on the number and size of the RBC; males 40.7 -50.3%; females 36.1 - 44.3 % females.
ameoba
a unicellular organism
amoeboid motion
moving like an amoeba
Non specific defenses: 1st line
physical barriers like skin
nonspecific defenses: 2nd line
phagocytic WBCs
special defenses
the immune system
granulocytes
WBCs that have granules in their cytoplasm
Lobed nuclei
a nucleus that is divided into connecting lobules
cytoplasm
gel like (mainly water) inside cells
nucleoplasm
the gel-like cytoplasm inside the nucleus
neutrophils
granulocytic WBC, most predominant, multiobed, polymorphonuclear, increases in bacterial infections, 50-70%
Eosinophils
granulocytic WBC, two-lobed nucleus, increased in parasitic infections and allergies. 2-4%
Bilobed nucleus
a cell with 2 lobes that are connected
cytoplasmic granules
structures in the cytoplasm with a variety of functions
lysosome
one type of cytoplasmic granule, involved in breaking things down
Eosinophila
increase in eosinophils
basophils
another granulocytic WBC, release histamine, 0.5-1%
vasodilator
dilates blood vessels
histamine
an example of a vasodilator
antigens
markers, identifiers, found on the cell membrane of cells
coagulant
to clot
anticoagulant
to work in opposition to clotting
Heparin
an example of an anticoagulant
Agranulocytes
WMCs that lack granules in their cytoplasm.
Lymphoid tissue
part of the lymphatic system
lymphocytes
an agranulocytic WBC, B cells and T cells. 25%
B Cells
a type of lymphocyte that produces antibodies
T Cells
a type of lymphocyte that includes helper T Cells, these cells directly attack pathogens.
Monocytes
a type of agranulocyte WBC, us shaped nucleus, become marcophages when they migrate into tissue. 3-8%
Macrophages
monocytes become macrophages when they go into tissues
Phagocytes
to engulf a particle
platelets
cell fragments involved in blood clotting
thromobocytes
platelets
hemostatis
the stopping of bleeding
megakaryocyte
a large cell in bone marrow that fragments into platelets
pH scale
measure [H+]
pH of plasma
7.35-7.45
pathogen
anything that causes disease
pathologic conditions
caused by or involving disease
heparinized blood samples
blood that is in a tube with heparin
leukocytosis
increased white blood cells
leucopenia
decreased white blood cells
leukemia
cancer of white blood cells
lymphocytic leukemia
leukemia involving lymphocytes
chronic
over long periods of time
acute
sudden, severe
polycythemia
increase in RBC volume
anemia
decrease in RBCs and/or hemoglobin
macrocytic hypochromic anemia
large RBC with little hemoglobin
microcytic hypochromic anemia
small RBC with little hemoglobin
differenial WBC
a lab test that determines the % of WBC
centrifuge
an instrument that separates solutes in solutions by density
capillary tubes
rely on adhesion to draw fluid into interior of tube
adhesion
different molecules sticking together
cohesion
same molecules sticking together
microhematocrit tube
small capillary tubes
Tallquist hemoglobin scale
assess patient’s hemoglobin
colorimeter
an instrument that detects color changed
calibrated
determines the correctness of a certain device.
spectrophotometer
an instrument that can read the transmission of absorption of light through a tube.
Hemoglobinometer
detects hemoglobin
bleeding time
used to determine how quickly a patient stops bleeding
blood clotting or coagulation time
assesses clotting factors
clotting factors
including fibrinogen & calcium
procoagulants
a precursor to a blood factor
tissue factor
initiates clotting
PF3
platelet factor 3, a blood coagulation factor
calcium ions
another coagulation factor
prothrombin activator
acivates prothrombin
prothrombin
gets converted to thrombin
thrombin
involved in the conversion of fibrinogen to fibrin
fibrinogen
gets converted to fibrin, plasma protein, involved in clotting, 4%
fibrin
an insoluble protein, major component of a blood clot
autoclave
a pressure chamber that sterilizes equipment
glycoproteins
anitgens on RBCs
Agglutinogens
A & B red blood cell Ags. glycoproteins
antibodies
immunoglobulins, gamma globulins, specific attackers to specific antigens.
agglutinins
antibodies against A or B agglutinogen
Kell, Lewis, M and N
other antigens on human RBCs
Rh antigen
another RBC antigen
Sensitized
someone that has antibodies to a certain antigen
hemolysis
a RBC that breaks apart
lancets
a cutting instrument.
EDTA
a common anticoagulant
Arteriosclerosis
any problems with the walls of the arteries
Atherosclerosis
fat build up in the walls of arteries
occluded
blockage
hypertensive
high blood pressure
Thrombi (pl) thrombus (s)
a blood clot
emboli (pl), embolus (s)
traveling blood clot
smooth muscle plaques
plaque in the walls of blood vessels
cholesterol
an essential fat
High density lipoprotein HDL
good cholesterol
Low density lipoprotein LDL
bad cholesterol
alkaline
base
buffer
resists changes in pH
pH scale increments
increments of 10, each increment is 10 times the next increment.
1 liter = ml
1000 ml
1ml = microliters
1000 microliters
solutions
a mixture (no chemical reactions, no bonds broken or maed)
solvent
universal solvent is water
solute
the substance dissolved in the solution
pluripotent
a cell that can differentiate into any cell of that body
totipotent
a cell that can develop into a whole organism, ex. zygote: a fertilized egg
blasts
partially differentiated
lymphoid
of the lymphocytes
myeliod
of the monocytes, granulocytes, mast cells & RBCs
commited cells
programmed cells
prokaryotes
bacteria cells that lack a nuclear membrane around their DNA
eukaryotes
cells that have a nuclear membrane (nucleus) around their DNA.
organelles
structures inside cells
lysosome
contain digestive hydrolytic enzymes (breaking things down)
cytoskeleton
internal framework of a cell
nucleus
contains the DNA
polymorphonuclear
the nucleus has many lobes
mitochondria
where aerobic cellular respiration occurs
ribosomes
where proteins are made
biomolecules
molecules of life
organic
contains carbon AND hydrogen
carbohydrates
sugars( most end is -ose) (glyco-)
lipids
fats - triglyceride, cholesterol
nucleic acids
DNA, RNA
Proteins
made of amino acids
cofactor
required for enzyme activity (metal ions, calcium,mag)
coenzymes
if the cofactor is organic, most are vitamins.
Vitamins
fat soluble: K,A,D,E; water soluble C and all B
B vitamins
b1 (thiamine) b2(riboflavin) b3 (niacin) B5 (pantothenic acid) B6 B7 (biotin) B12 Folic Acid
salts
ionic compounds
nitrogenous substances
contain nitrogen
urea
nonprotein nitogenous substance, CH4N2O (amino acids-ammonia-urea)
uric acid
nonprotein nitrogenous substance, a product of nucleic acid metabolism, can form crystals in joints (gout)
ammonium salts
nonprotein nitrogenous substance, result of NH3 & various acids
creatinine
a waste product that forms when creatine breaks down, nonprotein nitrogenous substance
electrolytes
carry an electrical charge
cations
positive ions, Na, K, Ca, Mg
anions
negative ions, Cl
ATP adenosine triphosphate
usable energy in the cell
ADP
adenosine diphosphate
vasodilation
increase in tube widith
vasoconstriction
decrease in tube width
synthesis
to build
-poiesis
make something
-penia
to decrease
-cyte
having to do with “cell”
-cytosis
an increase
Hema-
blood
-lysis
to breakdown, to break apart
hemolysis-hemolytic
RBC breaking apart
hydrolysis
breaking down a large molecule to small molecules involving adding water.
hematopoiesis (hemopoiesis)
the production of blood cells
hematocytoblasts
a partially differentiated stem cell that will become a blood cell
erythropoietin (EPO)
a hormone produced by Kidneys, targets red bone marrow
erythrocytes
Red blood cells
hemoglobin
a quaternary structure protein
oxyhemoglobin
hemoglobin with oxygen attached
deoxyhemoglobin
hemoglobin without oxygen attached.
globin
the protein part of hemoglobin
heme
a porphyrin (red)
Iron Fe
is attached to heme
carbaminohemoglobin
20% of CO2 is transported this way
anucleate
without a nucleus
spectrin
a cytoskeleton protein, 1st isolated in RBCs
reticulocytes
immature RBC, remnants of nucleus visible, newborns have higher % of retics
buffy coat
the faction of blood that contains WBC after the blood was centrifuged.
Globulin
36%, plasma protein, alpha and beta - transport proteins, bind to lipids, metal ions and fat soluble vitamines; gamma- antibodies, immunoglobulins IgG (RBC agglutinins), produced by B cell lymphocytes.
Albumn
60% of plasma proteins, smallest but msot abundant
osmosis
diffusion of water across cell membranes
antigens
markers, identifiers (canalso be on viruses)
glycolipids
involved in cell recognition.