Blood Transfusions Flashcards
what are the minimum criteria that need to be met to give blood?
Hb >135 in men and >125 in women
weight >50kg
how are red cells stored?
4C
up to 35 days
how is FFP stored?
at -30C
for up to 3 years
how are platelets stored?
at 22C
for 7 days
with agitation
what does FFP stand for?
fresh frozen plasma
what is FFP a source of?
clotting factors
what is cryoprecipitate and what does it contain?
further procesed FFP
a source of fibrinogen
what determines a person’s blood group?
their red cell antigens
what codes for a persons ABO group?
the ABO gene on chromosome 9
which gene is dominant in the ABO system?
A and B co-dominant over O
there is no O antigen, a patient just lacks the A/B gene
what is the most common ABO group?
O
what are the possible genotypes in people with blood group O?
OO
what are the possible genotypes in people with blood group A?
AA or AO
what are the possible genotypes in people with blood group B?
BB or BO
what are the possible genotypes in people with blood group AB?
AB
how is the ABO group inherited?
one ABO gene from each parent
what ABO types of blood can be given to people with blood group O?
O
what ABO types of blood can be given to people with blood group A?
O
A
what ABO types of blood can be given to people with blood group B?
O
B
what ABO types of blood can be given to people with blood group AB?
O
A
B
AB
what does landsteiner’s law state?
when an individual lacks the A or B antigen, the corresponding antibody is produced in their plasma
i.e. group A = antibodies for B
what antibodies are present in patients with blood group A?
anti B
what antibodies are present in patients with blood group B?
anti A
what antibodies are present in patients with blood group AB?
none
what antibodies are present in patients with blood group O?
anti A
anti B
is it more common to be rhesus positive or negative?
positive
85% of the population are RhD positive
what are the possible genotypes in an RhD+ patient?
DD or Dd
what are the possible genotypes in an RhD- patient?
dd
