Anti-Platelet Drugs Flashcards
1
Q
what is the MoA of aspirin?
A
inhibits cyclooxygenase which is needed to produce thromboxane A2 (a platelet agonist)
2
Q
what are the possible side effects of aspirin?
A
bleeding
blocked production of prostaglandins
3
Q
what can blocking production of prostaglandins cause?
A
GI ulceration
bronchospasm
4
Q
name two ADP receptor antagonists
A
clopidogrel
prasugrel
5
Q
what is the MoA of aspirin?
A
a phosphodiesterase inhibitor
increases production of cAMP which reduces platelet aggregation
6
Q
name a GPIIbIIIa inhibitor
A
abciximab
7
Q
what is the MoA of abciximab?
A
inhibits platelet aggregation
8
Q
when should anti platelet drugs be stopped prior to elective operations?
A
seven days before
9
Q
how can anti platelets be reversed if there is severe bleeding?
A
by giving a platelet transfusion
