Blood Physiology Lecture 6

Question 1

Blood clotting consists of a protein called __________

Answer 1

fibrin

Question 2

The essential part of a clot is the formation of _________

Answer 2

fibrin

Question 3

Secondary hemostasis occurs following a _________

Answer 3

platelet plug formation

Question 4

Secondary hemostasis involves a cascade of _______ activation

Answer 4

enzyme (clotting factors)

Question 5

In secondary hemostasis, activate of enzymes occur by ________

Answer 5

proteolytic cleavage

Question 6

In secondary hemostasis, formation of a _________, in which RBC become trapped and is called a red thrombus

Answer 6

gel-like fibrin clot

Question 7

There are _______ factors involved in blood clotting

Answer 7

13

Question 8

All the factors involved in blood clotting are present as ______ in the blood

Answer 8

inactive plasma proteins

Question 9

Many of the _________ involved in blood clotting take place on the surface of platelets

Answer 9

activation reactions

Question 10

Blood clotting factors are synthesized in the _______

Answer 10

liver

Question 11

What are the first 4 factors of blood clotting

Answer 11

1. Fibrinogen
2. Prothrombin
3. Tissue Thromboplastin
4. Ionized Calcium (not a protein)

Question 12

Generation of the active __________ is the key step in the clot formation pathway

Answer 12

thrombin enzyme

Question 13

How is a thrombin enzyme made during the key step which is the generation of the active thrombin enzyme?

Answer 13

An inactive enzyme prothrombin is converted to thrombin by the prothrombinase complex

Question 14

Thrombin is the active enzyme which converts the inactive protein _______- to the active form ________

Answer 14

1. Fibrinogen
2. Fibrin

Question 15

Fibrin is an ________ which upon stabilization becomes strong strands and forms a mesh-work, or the fibrin clot, in which cells get trapped

Answer 15

insoluble protein

Question 16

There are ____ pathways by which clotting factors are activated to form a common
activated factor, which is called ____

Answer 16

1. two
2. factor Xa

Question 17

Factor Xa is directly involved in the formation of _________.

Answer 17

active thrombin

Question 18

In the _________ pathway all the factors come from ________ the blood and the
blood vessel itself

Answer 18

1. Intrinsic
2. within

Question 19

The extrinsic pathway is initiated by some factors ___________

Answer 19

outside the blood vessel