Blood Groups Flashcards
1
Q
expression of blood groups
A
codominant
2
Q
blood groups that do not express Mendelian rules of inheritance
A
Xg and Kx
3
Q
formed when exposed to foreign antigens
A
alloantibodies
4
Q
antibodies that react to self antigens
A
autoantibodies
5
Q
key role of the complement system
A
hemolysis
6
Q
gene product of ABO
A
glycosyltransferases
7
Q
gene product of MNS
A
glycophorins
8
Q
gene product of P1PK
A
P1 antigen
9
Q
gene product of RH
A
RhD protein and RHCE protein
10
Q
gene product of Lutheran
A
Lutheran glycoprotein, B-CAM
11
Q
gene product of Kell
A
Kell protein
12
Q
gene product of Lewis
A
alpha-3/4-fucosyl transferase
13
Q
gene product of Duffy
A
DARC
14
Q
gene product of Kidd
A
HUT11
15
Q
gene product of Diego
A
Anion exchanger 1 (AE1), Band 3
16
Q
gene product of Cartwright
A
acetylcholinesterase
17
Q
gene product of Xg
A
CD99
18
Q
gene product of Scianna
A
HEMP
19
Q
gene product of Dombrock
A
ADP-ribosyl transferase (CD297)
20
Q
gene product of Colton
A
CHIP
21
Q
gene product of LW
A
ICAM (CD 242)
22
Q
gene product of Chido/Rogers
A
C4A and C4B complement glycoproteins
23
Q
gene product of Hh
A
alpha 1/2 fucosyl transferase
24
Q
gene product of Kx
A
Kx glycoprotein
25
gene products of Gerbich
glycophorin C and glycophorin D
26
gene product of Cromer
decay accelerating factor (DAF, CD 55)
27
gene product of Knops
complement receptor 1 (CD35)
28
gene product of indian
CD44
29
gene product of OK
CD147, extracellular matrix metalloproteinase inducer
30
gene product of Raph
tetraspanin (CD151)
31
gene product of JMH
semaphorin (CD108)
32
gene product of I
alpha 1/6- N acetylglucosaminyl transferase
33
gene product of Globoside
alpha 1/3 N-acetylglucosaminyl transferase
34
gene product of Gil
aquaglycoporin
35
gene product of RHAG
Rh-associated glycoprotein (CD 241)
36
single most important blood group
ABO
37
ABO blood group contains how many phenotypes
4 (A, B, AB, O)
38
discovered ABO blood group
Landsteiner in 1901
39
discovered AB
Von decastello and Sturli in 1902
40
immunodominant sugar of H
L-fucose
41
immunodominant sugar of A
N-acetylgalactosamine
42
immunodominant sugar of B
D-galactose
43
ABO chromosome
chromosome 1
44
H chromosome
chromosome 19
45
rarest bloodtype
Bombay
46
naturally occuring antobodies in Bombay
anti-A, anti-B and anti-H
47
ABO antibodies are detectable at what age?
3-6 months
48
antibody class of ABO
IgG and IgM
49
most reactive to anti-H
O
50
least reactive to anti-H
A1B
51
complete absence of H antigens
Oh
52
what are the major subgroups of A?
A1 and A2
53
anti-A1 lectin
Dolichos biflorus
54
ABO blood group discrepancy characterized by missing antibodies
type 1
55
ABO blood group discrepancy characterized by missing antigens
type 2
56
ABO blood group discrepancy characterized by abnormal plasma proteins
type 3
57
ABO blood group discrepancy characterized by miscellaneous causes
type 4
58
biological role of ABO blood groups
cause acute rejection in solid organ transplants
59
discovered the D antigen
Levine and Stetson
60
most common genotype in whites
R1r
61
most common genotypes in blacks
R0r
62
immunogenocity if Rh antigens
D>c>E>C>e
63
Tippet genetic theory
2 genes: RHD and RHCE
64
Fisher-Race genetic theory
3 genes
65
Weiner genetic theory
1 gene
66
chromosome of Rh
chromosome 1
67
how do you detect weak D?
IAT
68
How are weak D persons identified?
Rh (-) as blood recipients
Rh(+) as blood donors
Rh(-) Du (+)
69
antibody produced by Rhnull
anti-Rh29
70
how much Rh-positive RBCs are needed to induce alloantibody production?
<0.1 ml
71
Kell antigens are susceptible to?
DTT, AET, 2-ME, ZZAP
72
a zinc neutral endopeptidase is homologous to?
CALLA, CD10
73
characteristics of K0K0
lacks all Kell antigens
| increased expression of Kx
74
antibody produced by K0K0
anti-Ku (anti-KEL5)
75
most common immune antibody outside ABO and Rh
anti-K
76
confers resistance to Plasmodium vivax and Plasmodium knowlesii
-Fy; Fy (a-b-)
77
confers resistance to HIV
Fynull
78
very common cause of delayed HTRs
Kidd
79
most common MNS null phenotype
U-
80
lacks all MNS antigens due to deletion of GYPA and GYPB
Mk
81
lacks GYPA
En (a-); coincides with the loss of Wrb
82
antibody produced by dialysis patients
autoanti-N (anti-Nf)
83
confers resistance to Plasmodium falciparum
En (a-)
84
the only blood group no null phenotype
Diego
85
product of H antigen
FUT1
86
product of Se
FUT2
87
product of Le
FUT3
88
Null phenotype of Secretors
Le d
89
Null phenotype of non-secretors
Le c
90
what bacteria binds to Lewis antigen
Helicobacter pylori
91
epitope for CA 19-9
Sialyl-Le a
92
neutralizer of Lewis antigens
saliva
93
neutralizers of P antigens
hydatid cyst
94
biphasic hemolysin
Donath-Landsteiner
95
mechanism of Donath-Landsteiner antibodies
bonds at 4C, bursts at 37C
96
P1 can be receptors for
Shigella dysenteriae and EHEC
97
P can be receptors for
Parvovirus B19 and UPEC
98
Pk can be receptors for
Shigella dysenteriae, EHEC, UPEC,
| HIV, Streptococcus suis, Pseudomonas aeruginosa
99
blood group with increased expression on reticulocytesand sickle cells of sickle cell patients
Lutheran
100
Lutheran has high affinity receptor for
laminin
101
cause of PNH-III
Dombrock null
102
receptors for influenza virus
GYPC and GYPD
103
receptor for UHEC, E.coli, echovirus and Coxsackie B virus
CD55
104
receptor for Haemophilus influenzae
AnWj/CD44
105
neutralizer for I blood group
milk and/or urine
106
name given to HLA class I antigens
Bg
107
formerly known as Bennet-Goospeed
HLA-B7
108
Bg expressed in WBC
HLA-B27
109
Bg that is clinically benign
HLA-A28
110
appears as shiny and refractile under the microscope
anti-Sda
111
neutralizer of anti-Sda
urine
112
most severe HTR
ABO
113
antibody involved in intravascular red cell destruction
IgM; large amounts of complement
114
antibody involved in extravascular red cell destruction
IgG
115
antibodies that are often described as complement dependent
KIdd antibodies
116
alloimmunization is acquired via:
pregnancy
transfusion
disease (EBV and IM)
