Blood Component Preparation and Therapy/Distribution and Administration

Question 1

red cell survival in storage

Answer 1

70%

Question 2

red cell survival in 24 hours post transfusion

Answer 2

75% with 1% hemolysis

Question 3

supports ATP generation by glycolytic pathway

Answer 3

dextrose

Question 4

acts as substrate for red cell ATP synthesis

Answer 4

adenine

Question 5

prevents coagulation by chelating calcium and protects the RBC membrane

Answer 5

citrate

Question 6

prevents excessive decrease in pH

Answer 6

sodium biphosphate

Question 7

osmotic diuretic acts as a membrane stabilizer

Answer 7

mannitol

Question 8

maintains red cell metabolism during storage

Answer 8

additive solutions

Question 9

how many mL of additive should be used per volume of blood?

Answer 9

100 mL for a 450 mL whole blood

110 mL for a 500 mL whole blood

Question 10

when is the additive solution added to the whole blood?

Answer 10

within 72 hours of collection; extends storage to 42 days

Question 11

additive solutions include:

Answer 11

AS-1 adsol
AS-3 nutricel
AS-5 optisol

Question 12

restores 2,3-DPG and ATP in RBC units during storage or up to 3 days after expiration

Answer 12

rejuvination

Question 13

rejuvination solution contains:

Answer 13

PIGPA
pyruvate
inosine
phosphate 
glucose
adenine

Question 14

storage temperature for frozen RBC

Answer 14

40% glycerol: -65C

20% glycerol: -120C

Question 15

expiration of irradiated RBC

Answer 15

28 days from irradiation or original outdate

Question 16

expiration of thawed plasma

Answer 16

5 days from thawing

Question 17

blood product that is not FDA licensed

Answer 17

thawed plasma

Question 18

acceptable pH for platelets

Answer 18

pH>=6.2

Question 19

residual leukocytes in leukoreduced units

Answer 19

<5x10^6 residual leukocytes in:
85% leukoreduced RBC
95% leikoreduced platelets

Question 20

granulocytes in 75% units tested for apheresis granulocytes

Answer 20

> 1x10^10

Question 21

units for thalassemia patients

Answer 21

neocyte enriched

Question 22

frozen or deglycerolized red blood cells are for

Answer 22

rare blood types and autologous donations

Question 23

unit that prevents anaphylactic reactions

Answer 23

washed RBC

Question 24

given to patients with paroxysmal nocturnal hemoglobinuria

Answer 24

leukoreduced RBCs

Question 25

unit that prevents graft versus host disease and for blood units coming from the relative of the patient

Answer 25

irradiated RBCs

Question 26

indications for platelet components

Answer 26

cancer patients (chemotherapy/radiation therapy) stem cell transplants patients with post operative bleeding

Question 27

expected platelet increment/increase for a 70kg person

Answer 27

1 unit RDP: 5,000 to 10,000/uL | 1 unit SDP: 30,000 to 60,000/uL

Question 28

refractory also means

Answer 28

unresponsiveness

Question 29

refractory or unresponsiveness of platelet concentrates may result from

Answer 29

``` antibodies to HLA class 1 antigens platelet antibodies (ITP) neutrophil/lymphocyte antibodies ```

Question 30

corrected count increment (CCI)

Answer 30

determines the increase in platelet count

Question 31

when is CCI done?

Answer 31

before transfusion | within 1 hour of transfusion

Question 32

therapeutic dose of pooled platelets, platelet concentrates and platelet apheresis

Answer 32

1 unit/10kg body weight

Question 33

unts to replace stable and labile coagulation factors

Answer 33

FFP: all coaulation factors and DIC PF24: factor V and VIII

Question 34

therapeutic dose of FFP and PF24

Answer 34

10 to 20 mL/kg 3-6 units in an adult

Question 35

thawing of FFP and PF24

Answer 35

30-37C for 30 to 45 minutes

Question 36

light spin

Answer 36

2000xg 3 minutes

Question 37

heavy spin

Answer 37

5000xg 5 minutes

Question 38

elliptical agitator

Answer 38

1 rpm

Question 39

circular agitator

Answer 39

2-6 rpm

Question 40

whole blood for platelet preparation and plasma should be processed within:

Answer 40

6-8 hours

Question 41

ISBT 128 indicates

Answer 41

uniform labelling for international bar code recognition by computers

Question 42

unit cannot be returned if

Answer 42

storage was at room temperature for 15-30 minutes | seal is broken

Question 43

positive patient idetifcation is done using:

Answer 43

2 independent identifiers

Question 44

solution that should only be administered with blood components

Answer 44

ONLY normal saline

Question 45

hours of infusion

Answer 45

4 hours

Question 46

what should you do if transfusion reaction occurs during the transfusion

Answer 46

discontinue, check for clerical errors

Question 47

alternatives to transfusion (volume expanders)

Answer 47

crystalloids and colloids

Question 48

components of Ringer's solution

Answer 48

potassium calcium lactate