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Immunohematology > Blood Component Preparation and Therapy/Distribution and Administration > Flashcards

Blood Component Preparation and Therapy/Distribution and Administration Flashcards

1
Q

red cell survival in storage

A

70%

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2
Q

red cell survival in 24 hours post transfusion

A

75% with 1% hemolysis

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3
Q

supports ATP generation by glycolytic pathway

A

dextrose

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4
Q

acts as substrate for red cell ATP synthesis

A

adenine

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5
Q

prevents coagulation by chelating calcium and protects the RBC membrane

A

citrate

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6
Q

prevents excessive decrease in pH

A

sodium biphosphate

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7
Q

osmotic diuretic acts as a membrane stabilizer

A

mannitol

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8
Q

maintains red cell metabolism during storage

A

additive solutions

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9
Q

how many mL of additive should be used per volume of blood?

A

100 mL for a 450 mL whole blood

110 mL for a 500 mL whole blood

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10
Q

when is the additive solution added to the whole blood?

A

within 72 hours of collection; extends storage to 42 days

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11
Q

additive solutions include:

A

AS-1 adsol
AS-3 nutricel
AS-5 optisol

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12
Q

restores 2,3-DPG and ATP in RBC units during storage or up to 3 days after expiration

A

rejuvination

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13
Q

rejuvination solution contains:

A 
PIGPA
pyruvate
inosine
phosphate 
glucose
adenine
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14
Q

storage temperature for frozen RBC

A

40% glycerol: -65C

20% glycerol: -120C

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15
Q

expiration of irradiated RBC

A

28 days from irradiation or original outdate

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16
Q

expiration of thawed plasma

A

5 days from thawing

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17
Q

blood product that is not FDA licensed

A

thawed plasma

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18
Q

acceptable pH for platelets

A

pH>=6.2

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19
Q

residual leukocytes in leukoreduced units

A

<5x10^6 residual leukocytes in:
85% leukoreduced RBC
95% leikoreduced platelets

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20
Q

granulocytes in 75% units tested for apheresis granulocytes

21
Q

units for thalassemia patients

A

neocyte enriched

22
Q

frozen or deglycerolized red blood cells are for

A

rare blood types and autologous donations

23
Q

unit that prevents anaphylactic reactions

A

washed RBC

24
Q

given to patients with paroxysmal nocturnal hemoglobinuria

A

leukoreduced RBCs

25
Q

unit that prevents graft versus host disease and for blood units coming from the relative of the patient

A

irradiated RBCs

26
Q

indications for platelet components

A

cancer patients (chemotherapy/radiation therapy)
stem cell transplants
patients with post operative bleeding

27
Q

expected platelet increment/increase for a 70kg person

A

1 unit RDP: 5,000 to 10,000/uL

1 unit SDP: 30,000 to 60,000/uL

28
Q

refractory also means

A

unresponsiveness

29
Q

refractory or unresponsiveness of platelet concentrates may result from

A 
antibodies to HLA class 1 antigens
platelet antibodies (ITP)
neutrophil/lymphocyte antibodies
30
Q

corrected count increment (CCI)

A

determines the increase in platelet count

31
Q

when is CCI done?

A

before transfusion

within 1 hour of transfusion

32
Q

therapeutic dose of pooled platelets, platelet concentrates and platelet apheresis

A

1 unit/10kg body weight

33
Q

unts to replace stable and labile coagulation factors

A

FFP: all coaulation factors and DIC
PF24: factor V and VIII

34
Q

therapeutic dose of FFP and PF24

A

10 to 20 mL/kg 3-6 units in an adult

35
Q

thawing of FFP and PF24

A

30-37C for 30 to 45 minutes

36
Q

light spin

A

2000xg 3 minutes

37
Q

heavy spin

A

5000xg 5 minutes

38
Q

elliptical agitator

39
Q

circular agitator

40
Q

whole blood for platelet preparation and plasma should be processed within:

41
Q

ISBT 128 indicates

A

uniform labelling for international bar code recognition by computers

42
Q

unit cannot be returned if

A

storage was at room temperature for 15-30 minutes

seal is broken

43
Q

positive patient idetifcation is done using:

A

2 independent identifiers

44
Q

solution that should only be administered with blood components

A

ONLY normal saline

45
Q

hours of infusion

46
Q

what should you do if transfusion reaction occurs during the transfusion

A

discontinue, check for clerical errors

47
Q

alternatives to transfusion (volume expanders)

A

crystalloids and colloids

48
Q

components of Ringer’s solution

A

potassium
calcium
lactate

Immunohematology (5 decks)

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