Blood Gas and Acid Base Flashcards

1
Q

Why do you not want a venous sample for blood gas?

A

does not give direct measurement of arterial oxygenation

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2
Q

How do you properly collect a sample for blood-gas?

A

use a heparinized syringe and fill it completely to prevent diffusion of gases into air space at the top of the tube

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3
Q

How do you store a sample collected for blood-gas?

A

store at room temp. for up to 30 mins. before changes in acid-base will be seen
changes in PO2 will occur in 12 mins.

if analysis cannot be performed immediately, place sample in a 4 degree water bath for no longer than 3 hrs

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4
Q

At physiologic pH of ____ 95% of potential CO2 gas is in the form of _______.

A

At physiologic pH of 7.4, 95% of potential CO2 gas is in the form of bicarbonate.

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5
Q

When analyzing HCO3 and PCO2 for Acid-Base eval., which refers to metabolic changes and which refers to respiratory changes?

A

HCO3- : metabolic

PCO2 : respiratory

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6
Q

Compensatory changes are in response to primary acid-base changes. Primary acid-base changes go with/against the direction of pH.

A

Primary acid-base changes go WITH the direction of pH.

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7
Q

What is Base Excess/Base Deficit?

A

Metabolic non-respiratory component that reflects acid-base regulating ability of the kidneys (HCO3-) and the blood (hemoglobin) buffer system.

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8
Q

Base Excess =

A

Alkalosis

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9
Q

Base Deficit =

A

Acidosis

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10
Q

Metabolic Compensatory Mechanisms…for each 1mEq/L change in HCO3-, you expect…

A

0.7mmHg change in pCO2 in the same direction

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11
Q

Acute Respiratory Acidosis..for each 1mmHg change in pCO2, you expect…

A

0.15mEq/L change in HCO3-

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12
Q

Chronic Respiratory Acidosis…for each 1mmHg change in pCO2, you expect…

A

0.35mEq/L change in HCO3-

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13
Q

Acute Respiratory alkalosis…for each 1mmHg change in pCO2, you expect..

A

0.25mEq/L change in HCO3-

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14
Q

Chronic Respiratory alkalosis…for each 1mmHg change in pCO2, you expect…

A

0.55mEq/L change in HCO3-

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15
Q

What does blood gas measure?

A
pH
pO2
pCO2
HCO3-
O2 Sat.
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16
Q

What effect does PTH have on Ca2+ and Ph?

A

PTH –> Increase Ca2+ and Decrease Ph

17
Q

What effect does Calcitriol (activated Vit. D) have on Ca2+ and Ph?

A

Calcitriol –> Increase Ca2+ and Increase Ph

18
Q

What effect does Calcitonin have on Ca2+ and Ph?

A

Calcitonin –> Decrease Ca2+ and Decrease Ph

19
Q

In small animal, hypocalcemia CSs are…

A

muscle tremors/convulsions, ataxia, flaccid paralysis, weakness and tetany

20
Q

In horse, hypocalcemia CSs are..

A

synchronous diaphragmatic flutter, tetany, stilted gait, muscle tremors, recumbency, convulsions, and cardiac arrhythmias

21
Q

In cows, hypocalcemia CSs are…

A

weakness and recumbency

22
Q

What causes hypocalcemia?

A

renal disease
pancreatitis
parturition

23
Q

In a patient w/ renal disease and hypocalcemia, the renal disease if often secondary to..

A

hyperparathyroidism

PTH is stimulated from low iCa2+ –> Vit D production impaired due to renal insufficiency –> metabolic acidosis will mask hypocalcemia even if total Ca2+ is decreased

24
Q

In a patient w/ pancreatitis and hypocalcemia…

A

Ca2+ is binding to fat –> decreases [Ca2+]

25
Q

What 2 conditions might you see in patient(s) undergoing parturition w/ hypocalcemia..

A

Milk Fever: seen in high production dairy cows caused by low blood Ca2+ levels that result in paresis

Lactation Tetany: a metabolic disease seen in horses caused by low blood Ca2+ levels in association w/ lactation

26
Q

What are the toxic causes of hypocalcemia?

A

Etylene glycol toxicosis
Blister Beetles (Cantharidin)
Oxalate-Rich Plants: soluble oxalates rapidly combine w/ serum Ca2+ and Mg2+
Insoluble Ca-Oxalate: filtered by the kidneys causing sever damage to the tubules –> Oxalate nephrosis

27
Q

What CSs are associated w/ hypercalcemia?

A

tissue mineralization, V/D, lethargy, inappetence, ms. weakness, shivering, bradycardia/arrhythmias

28
Q

Mechanism of hypercalcemia…

A

calcium inhibits ADH –> PU –> PD –> Dilute urine and renal tubular injury