Blood Coagulation Flashcards
1
Q
What is Hemostasis
A
.
2
Q
How do intact endothelial cells of blood vessels prevent blood clotting
A
.
3
Q
What is thrombomodulin
A
- integral membrane protein
- expressed on surface of endothelial cells
- cofactor for thrombin
- It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme.
4
Q
How is platelet aggregation avoided?
A
- vasodilators nitric oxide and prostacyclin
5
Q
What happens when an endothelial injury occurs?
A
Von Willebrand Factor’s primary function is binding to other proteins, in particular factor VIII, and it is important in platelet adhesion to wound sites
6
Q
What are the 3 steps of hemostasis?
A
.
7
Q
What is vascular thrombosis?
A
.
8
Q
How can a Thrombus occur?
A
.
9
Q
What is an embolism
A
/
10
Q
Where is Thrombosis more common?
A
.
11
Q
What is Fibrinolysis?
A
.
12
Q
How does fibrinolysis occur?
A
.
13
Q
What is Thrombin
A
.
14
Q
What are anticoagulants - how do they work
A
.
15
Q
Describe Thrombocytes - structure, where they come from, lifespan,
A
.
16
Q
What does antithrombin do
A
/
17
Q
What does Protein C do
A
.
18
Q
What does Protein S do
A
.
