Blood Clots

Question 1

3 steps of clot formation

Answer 1

vessel constriction, platelet adhesion, cross linking of fibrin through coagulation cascade

Question 2

Prostaglandin F 2a and Thromboxane A2 are what?

Answer 2

Potent vasoconstrictors-helps limit hemorrhage

Question 3

ADP and Serotonin are involved in what?

Answer 3

platelet aggregation

Question 4

coagulation cascade is intitiated by what?

Answer 4

TF binding with factor VII which activates it to VIIa

Question 5

Is intrinsic or extrinsic pathway more important?

Answer 5

extrinsic

Question 6

cascade ultimately leads to

Answer 6

Thrombin which activates Factor XIII that cross links the fibrin mesh

Question 7

small protein that is a serine protease inhibitor-inactivates coagulation

Answer 7

Antithrombin

Question 8

Protein C zymogen is activated when it

Answer 8

binds to thrombin

Question 9

single chain polypeptide which can reversibly inhibit factor Xa

Answer 9

Tissue factor pathway inhibitor

Question 10

which protein cuts fibrin to help break down clots?

Answer 10

plasmin

Question 11

Streptokinase, urokinase, reteplase, alteplase, tenecteplase are all

Answer 11

fibrinolytics-used to break down thrombi

Question 12

these drugs act on antithrombin

Answer 12

indirect thrombin inhibitors-heparin

Question 13

Fondaparinux works exactly like____

Answer 13

Heparin-binds to AT

Question 14

Drugs that act on anti-thrombin are considered what?

Answer 14

indirect inhibitors

Question 15

Drugs that act on fibrinogen and block its activity are considered

Answer 15

direct thrombin inhibitors

Question 16

Coumarins (anti coagulant) works by what mechanism?

Answer 16

Blocks the conversion of oxidized vitamin K back to the reduced form. The body then runs out of reduced vitamin K and thrombin becomes inactive.

Question 17

antidote for warfarin overdose

Answer 17

vitamin K, aqua mephyton

Question 18

Antidote for heparin overdose

Answer 18

protamine sulfate

Question 19

Aspirin inhibits what?

Answer 19

thromboxane A2 synthesis

Question 20

Clopidogrel works by blocking what?

Answer 20

ADP receptors

Question 21

Epifbatide and tirofiban work by blocking what?

Answer 21

GPIIb/IIIa

Question 22

Bleeding disorders are treated by what?

Answer 22

replacement therapy