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BOC 2024 > Blood Bank > Flashcards

Blood Bank Flashcards

1
Q

A prospective donor with which of the following health histories would be accepted for blood donation?
A. Hep B ig 2 months ago
B. HIV prevention drugs 6mo ago
C. Blood transfusion 2 months ago
D. Travel to malaria endemic country 1 month ago

A

B. HIV prevention drugs 6mo ago

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2
Q

During storage, the concentration of 2,3-diphosphoglycerate decreases in a unit of:
A. Platelets
B. Fresh Frozen Plasma
C. Red Blood Cells
D. Cryoprecipitated AHF

A

C. Red Blood Cells

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3
Q

The observed phenotypes in a particular population:
Jk (a+b-) = 122
Jk(a+b+) = 194
Jk(a-b+) = 84
What is the gene frequency of Jka in this population?

A

0.55

Use the hardy weinberg p2+2pq+q2=1.0

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4
Q

Anti-Fy3 will fail to react with which of the following enzyme-treated red cells?
A. Fy(a+b-)
B. Fy(a-b+)
C. Fy(a-b-)
D. Fy(a+b+)

A

C. Fy(a-b-)

Fy3 antigen is present on cells that express Fya and Fyb antibens. Fy3 is not found on Fy(a-b-) red cells and is resistant to enzyme treatment

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5
Q

In a random population, 165 of the people are Rh-negative (rr). What percentage of the Rh positive population is heterozygous for?
A. 36%
B. 48%
C. 57%
D. 66%

A

B. 48%

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6
Q

What is the hardy weinberg equation?

A

p2+2pq+q2=1.0

P2 = dominant homo
2pq = hetero
q2 = recessive homo

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7
Q

Which of the following antibodies is neutralizable by pooled human plasma?
A. anti-Kna
B. anti-Ch
C. anti-Yka
D. anti-Csa

A

B. anti-Ch

Cells react to trace amount of C4 complement

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8
Q

What increases during RBC Storage?

A
  • Lactic acid
  • Plasma K+
  • Plasma hemoglobin
  • Microaggregates
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9
Q

What decreases during RBC storage?

A
  • ATP
  • 2,3-DPG
  • pH
  • Glucose
  • Viable cells
  • Labile coagulation factors
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10
Q

During storage RBCs have a shift to the left of the O2 dissociation curve, this means an increase in ____ and a decrease in ___

A

A shift to the left means an increas of Hgb/O2 affinity and a Decrease in O2 delivery to tissues

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11
Q

ABO frequencies of Whites

A

O = 45%
A = 40%
B=11%
AB=4%

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12
Q

What blood type is higher in asians compaired to other races?

A

Group B

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13
Q

Which antibodies are naturally occuring?

A
  • ABO
  • Lewis
  • P1
  • MN
  • Lua
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14
Q

Antibodies that are Clinically significant

A
  • ABO
  • Rh
  • Kell
  • Duffy
  • Kid
  • SsU
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15
Q

Warm antibodies

A
  • Rh
  • Kell
  • Diffy
  • Kidd
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16
Q

Cold antibodies

17
Q

Usually only react in AHG

A

Kell, Duffy Kidd

18
Q

Can react at any phase of testing

19
Q

Enhanced by enzymes

A

Rh, Lewis, Kidd, P1

20
Q

Not detected with enzyme treatment of test cells

21
Q

Enhanced by acidification

22
Q

Show dosage

A

Rh other than D, MNS, Duffy, Kidd

23
Q

Bind complement

A
  • I
  • Kidd
  • Lewis
24
Q

Cause in vitro hemolysis

A
  • ABO
  • Lewis
  • Kidd
  • Vell
  • some P1
25
Associated with paroxysmal nocturnal hemoglobinia
Anti-P
26
Associated with cold agglutinin disease & Mycoplasma pneumoniae infections
Anti-I
27
Associated with infectious mononucleosis
Anti-i
28
K
9%
29
Fya
White68% Black92%
30
Fyb
White80% Black23%
31
Jka
76% 92%
32
What reagent is described by: Reduces net neg charge of RBCs, allowing them to come closer together?
Albumin
33
What reagent is defined as: Allows antigens and antibodies to move closer together more rapidly. Reduces incubation time for IAT
LISS
34
Which reagent: Increases antibody uptake used for detection and ID of weak IgG abs
PEG
35
Which reagent is described as: Reducing RBC surface charge by cleaving sialic acid molecules. M, N, S, Fya, Fyb antigens destroyed
Enzymes

BOC 2024 (11 decks)

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