BLOOD AND TISSUE NEMATODES Flashcards
vector-borne filarial nematode genus associated w human infections
Mansonella spp.
three species of Mansonella
M. ozzardi
M. perstans
M. streptocera
Mansonella spp.: primary vectors
biting midges (Midge fly) of genus Culicoides
Mansonella spp.: a New World species w a patchy distribution; endemic to Central America
M. ozzardi
Mansonella spp.: an Old World species that occurs in tropical regions of West and Central Africa
M. streptocerca
Mansonella spp.: endemic throughout West, East, and Central Africa
Mansonella perstans
M. perstans was likely introduced where?
neotropical regions of Central and South America
Mansonella spp.: symptomatic or asymptomatic infection?
asymptomatic
M. perstans and M. ozzardi diagnosed by?
finding microfilariae cicrulating in BLOOD
M. streptocerca is usually diagnosed by?
finding microfilariea in SKIN SNIPS
standard treatment for mansonellosis
none
combination therapy for M. perstans mcirofilaremia?
diethylcarbamazine + mebendazole
diagnostic stage for filariasis
microfilaria
Filariasis: infective stage to the midge
microfilariae
unique characteristic of M. perstans
has blunt rounded tail w nucleus extending to the tip; unsheated
difference of M. perstans from Loa Loa
Loa Loa is SHEATED (clear ext. found in the body of the mcirofilaria)
unique characteristic of M. streptocerca
has a hook-tail
Mansonella spp.: infective stage to humans
L3 larvae
mode of transmission from midge to humans
L3 enters through BITE WOUND of the midge fly
vectors for M. ozzardi
Arthropod
- black fly of genus Simulium
- midge of genus Culicoides
unique characteristic of M. ozzardi
body nuclei do NOT extend to tip of tail; long, thin pointed tail
drug of choice for filariasis
DEC (diethylcarbamazine)
treatment for M. ozzardi
ivermectin
treatment for M. streptocerca
DEC
Ivermectin
treatment for M. perstans
DEC + mebendazole (most widely used)
Mebendazole
Doxycycline
common name for Dracunculus medinensis
Guinea worm
Medina worm
Fiery serpent
Dracunculus medinensis: disease
dracunculiasis
Dracunculus medinensis: parasite is freq. found in?
subcutaneous tissues
muscles of human, dog, cattles & horses
Dracunculus medinensis: disease causes what?
cutaneous nodules
subsequent ulcers
Dracunculus medinensis: larvae difference of survival duration between clean water and muddy water
Clean water: 6 days
Muddy water: 2-3 weeks
Dracunculus medinensis: infective stage
L3 larva
Dracunculus medinensis: definitive host
humans, dogs, horses
Dracunculus medinensis: intermediate host
cyclops, copepods
Dracunculus medinensis: mode of transmission to humans
human drinks unfiltered/contaminated water containing copepods w L3 larvae
Dracunculus medinensis: treatment
- removal of worm
- filtering water sources
- avoid contact w contaminated water
Dracunculus medinensis: drug of choice
none
Dracunculus medinensis: best treatment to prevent infection
filtering water sources