Block 9 Drugs - Pituitary Hormones Flashcards by Nicolas Dawson | Brainscape

Q

Somatotropin (rHGH)

A

MOA: GH receptor agonist

USE: GH deficiency

Turner Syndrome

Short bowel syndrome

Wasting syndromes

S/E: Rare in children

Intracranial hypertension

Vision issues

Headache

Unique: Most effects are through IGF-1

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Mescarmin

A

MOA: IGF-1 receptor agonist

USE: IGF-1 deficiency

S/E: Hypoglycemia

Intracranial hypertension

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Octreotide

A

MOA: Somatostatin receptor agonist

USE: Gigantism

Acromegaly

S/E: GI issues

Nausea

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lanreotide

A

MOA: Somatostatin receptor agonist

USE: Gigantism

Acromegaly

S/E: GI issues

Nausea

Unique: Longer lasting than Octreotide

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Pegvisomant

A

MOA: GH receptor antagonist

USE: Gigantism

Acromegaly

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Bromocriptine

A

MOA: Dopamine receptor agonist

USE: Prolactinemia

S/E: Nausea

Vomiting

Headache

Postural hypotension

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Cabergoline

A

MOA: Dopamine receptor agonist

USE: Prolactinemia

S/E: Nausea

Vomiting

Headache

Postural hypotension

CI: Linked to valvular heart disease

Unique: Preferred over Bromocriptine due to lowere side effects

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Leuprolide

A

MOA: GnRH agonist

USE: Endometriosis

Uterine Fibroids

Prostate cancer

Precocious puberty

S/E: Hot flashes

Tiredness

Headache

Nausea

Unique: Down-regulates receptor over time to inhibit signaling

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Goserelin

A

MOA: GnRH agonist

USE: Endometriosis

Prostate cancer

Breast cancer

S/E: HOt flashes

Tiredness

Headache

Nausea

Unique: SubQ implant

Down-regulates receptor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Histrelin

A

MOA: GnRH agonist

USE: Precocious puberty

prostate cnacer

S/E: Hot flashes

Tiredness

Headache

Nausea

Unique: SubQ implant

Down-regulates receptor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Naferelin

A

MOA: GnRH agonist

USE: Endometriosis

Precocious puberty

S/E: Hot flashes

Tiredness

Headache

Nausea

Unique: Nasal spray

Down-regulates receptor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Follitropin α, ß

A

MOA: FSH receptor agonist

USE: Fertility drug

CI: Uterine or breast cancer

Multiple births

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lutropin α

A

MOA: LH receptor agonist

USE: Fertility drug

CI: Uterine or breast cancer

Multiple births

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Oxytocin

A

MOA: Oxytocin receptor agonist

USE: Augment labor

S/E: Rare if used correctly

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Atosiban

A

MOA: Oxytocin receptor antagonist

USE: Tocolysis (preterm labor)

Unique: NOT FDA APPROVED

(Used in Europe)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Vasopressin

A

MOA: Vasopressin receptor agonist

USE: Antidiuretic

S/E: Vasoconstriction

Headache

Nausea

CI: Coronary artery disease

Q

Desmopressin

A

MOA: Vasopressin receptor agonist

USE: Antidiuretic

S/E: Headache

Nausea

Unique: DOES NOT induce vasoconstriction like vasopressin

Q

Conivaptan

A

MOA: Vasopressin receptor antagonist

USE: Hyponatremia

Acute heart failure

CI: Kidney/urination issues

Q

Tolvaptan

A

MOA: Vasopressin receptor antagonist

USE: Hyponatremia

Acute heart failure

CI: Kidney/urination issues