Block 7 Flashcards

1
Q

ACI/D

A

TNFa & IFNy dec EPO; IL6 inc hepcidin (ACP made by liver) -> bind ferroportin -> inhib Fe2+ transport -> high ferritin

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2
Q

nonmegalo anemia causes

A

alc/cirrhosis/liver dz, reticulocytosis; Diamond Blackfan -> congen RBC aplasia (tx w/ corticosteroids, transfusion, HCT), MDS, post splenectomy

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3
Q

details you forget about sphero vs PNH vs G6PD vs PKD vs W/CAIHA vs PCH vs drug AIHA

A

splenomeg, neg Coombs, post op Howell Jolly vs acquired PIGA or from AML, venous thrombosis, flow cytom or sucrose, neg Coombs, ecluzimab vs back/abd pain, degmacytes vs AR PKLR 1q21, echino/burr, rigid & 2/3 BPG, mitivapat vs spherocytes vs DL ab to P ag vs ceph, PCN -> sphero, schistocytes

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4
Q

details you forget about ITP vs TTP/HUS vs vWF dz vs vit K defic vs AT defic vs protein C defic vs antiphospholipid ab

A

consumed by splenic macs, dec megakaryocytes on smear, tx steroids/IVIG vs tx plasmapheresis vs inc PTT/bleeding time, dec ristocetin, tx desmopressin vs inc PT/INR vs AD SERPINC1, nephrotic, tx w/ warfarin vs warfarin nec -> tx w/ LMWH vs lupus anticoag inc PTT, anticardiolipin false pos syphilis

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5
Q

details you forget AML vs APML vs ALL vs CML vs CLL vs HCL

A

7/3 cytarabine/idarubicin vs PML 15/RAR 17, DIC vs TdT vs BCR-ABL fusion, low LAP, imatinib vs smudge, CD5, LAD vs CD103, TRAP+, splenomeg

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6
Q

details you forget: follicular vs mantle vs DLBCL vs Burkitt vs Hodgkin

A

macs vs cyclin D1 on 11/igG heavy on 14, tx w/ -zomib vs B sxs, RCHOP vs CD21, cmyc, starry sky, macs w/ ingested apop vs B sxs, CD15/30, BCL2 stain, AVBD; nodular sclerosing -> mediastinal, mixed cell -> neu/eos/macs/plasma cells

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7
Q

JAK2 mutation: polycy vera vs essential thrombocythemia vs PMF. Langerhans histocytosis: eos vs Hand Schuller vs Letterer dz

A

dec EPO, inc H&H vs inc PLT vs dry tap, dacrocytes/tear drop cells. children, bone vs 3ad exophthalmos, scalp, DI vs <2yo, diffuse skin rash, severe bone lesions

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8
Q

Osler Weber Rendu. Tumor Lysis

A

AD defect TGFB on angiogen -> telangiectasia, AVM, iron defic anemia, bleed easy. hypoCa2+ -> tetany, myalgia; hyperK/P/uric -> arrhythmia, nephrolith

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9
Q

ciguatoxin. Hg vs Ar poisoning

A

neuro/depol, GI, cold allodynia; tx = support -> mannitol for neuro, antiemetics, CCB for lingering sxs. tremor, neuropsych, gingivostomatitis, hem GI-itis/renal fail; tx w/ dimer if acute or succimer vs GI, garlic; tx w/ dimer or succimer

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10
Q

what class is imipramine in? ketorolac? details you forget: AIP vs PCT. psoriasis path

A

TCA. NSAID. abd pain vs excess hair growth, excess Fe/inc ferritin. hyper/parakeratosis, thick corneum & spinosum, thin granulosum, hypervasc dermal papillae

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11
Q

blood smear for thal vs sickle vs PMF. Langerhans histiocytosis

A

target cells, teardrop cells/dacrocytes vs target cells, Howell Jolly vs teardrop cells/dacrocytes, dry tap. immature dendritic cells; S100, CD1a & 207, Birbeck granules

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12
Q

causes of panniculitis/erythema nodosum. details you forget: NF vs TS vs Sturge Weber vs vHL

A

Histo/Coccoid, sarcoid, Crohn’s, Behcet, GAS. AD; pheo, cataracts vs AD; renal angiolipoma, astrocytoma, rhabomyoma vs spont mutation, port wine vs AD chrm 3 -> inc HIF; pheo

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13
Q

details you forget: Wern-Korsakoff vs Tourette vs delirium. biochem of schizo

A

dmg ant thal too, anterograde > retro vs <18yo >1y, tx psychoedu, CBT, tetrabenzamine, haloperidol but AE, a2 ag w/ no AE vs EEG rhythm slowing; tx dec sleep disturb, inc cog stim, antipsych prn. high DA & dendritic branching

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14
Q

OCD is ego-? how to tx phobias. anorexia vs bulimia vs binge eating

A

egodystonic. desensitization, reexposure, CBT. fear gaining wt, body distortion, low BMI; tx nutrition, CBT, olanzapine vs nml or overwt BMI; tx nutrition, CBT, SSRI vs tx CBT, SSRI, lisdex

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15
Q

borderline vs histrionic vs narcissistic. avoidant vs dependent vs OCPD

A

unstable mood & relationships, fear abandon, impulse vs attn seeking esp w/ physical appearance vs grandiose, entitled, no empathy but fragile self esteem & envi of others. fear rejection, timid, want relationships but shy vs clingy, excess desire for relationship/support -> abusive relationship, low self confidence vs egosystonic, need everything under their ctrl

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16
Q

amphet/cocaine tox

A

mydriasis, high bp/tachy, hyperalert/awake, grandiose/euphoria, death from arrhythmia. cocaine -> vasoconstrict nasal septum & inc DA