Blinding

Question 1

Open label

Answer 1

-all parties are aware of the treatment being received

Question 2

Single blind

Answer 2

-either the patient or clinician is unaware of the treatment assignment

Question 3

Double blind

Answer 3

-both the patient and investigator are unaware of the allocated treatment

Question 4

Triple blind

Answer 4

-the patient, the investigator and those who adjudicate the study outcomes are unaware of the allocated treatment

Question 5

Unblinding

Answer 5

-the disclosure, planned or unintended of the allocation of one, a group or all of the participants

Question 6

Blinding

Answer 6

-refers to the secrecy that follows the group assignment until the completion of the study

Question 7

Allocation concealment

Answer 7

• from the time of sequence generation to the time of allocation the sequence is kept secret
• it is always possible to conceal the allocation

Question 8

Allocation sequence

Answer 8

• person generating must not be the same person who recruits
• if possible this must use a centralised or remote randomisation
• serially numbered, opaaque, sealed envelopes containing the random sequence is employed if the personnel are involved in generating and assigning
• SNOSE