Bleeding tendencies Flashcards
1
Q
Vitamin K dependant factors
A
EXTRINSIC pathway
factors 2,7,9,10
Newborn babies have physiological vit K deficiency - administer vit K to prevent haemorrhagic disease of newborn
warfarin is a vit K antagonist
2
Q
Deficiency of factor 8 and 9
A
Haemophilia A - factor 8 Haemophilia B - factor 9 Haemophilia C - factor 11 INTRINSIC pathway haemophilia bleeds into joints
3
Q
Screening tests if patient present with bleeding
A
prothrombin time - < 12sec (neonate 12-18 sec) extrinsic and common pathway vit K deficiency liver disease HDN warfarin and rat poison DIC
activated partial thromboplastin time APTT; PTT - 25-40 sec; neonate: 70 sec intrinsic and common pathways haemophilia vW disease heparin DIC
