Bladder Disorders & Urinary Incontinence Flashcards
Signs of Glomerular Bleeding
Red cell casts: glomerulonephritis
Dysmorphic RBCs
Proteinuria with hematuria with a large percentage being albumin
Etiologies for Non-glomerular Hematuria
UTI: acute cystitis, pyelonephritis Kidney trauma Stones: calyx, ureter Contamination at menstruation or postpartum Fistula Endometriosis BPH Vigorous exercise Post strep glomerular nephritis IG nephropathy Cancer: over 40
Risk Factors for Malignancy
Age: 35+ Smoking history Occupational exposure to chemicals/dyes Hx of gross hematuria Hx of chronic cystitis or irritative voiding symptoms Hx of pelvic irradiation Exposure to cyclophosphamide Hx of chronic indwelling FB Hx of analgesic abuse
Hematuria Work-Up
Urine culture
Urine cytology
Imaging: CT IVP, US (pregnant women)
Cystoscopy
Negative Work-up of Hematuria in Young & Middle-age Patients
Mild glomerular disease
Predisposition to stone disease
Negative Work-up of Hematuria in Patients at High Risk for Malignancy
Need annual UA
May need another work-up in 1-3 years
Monitoring for Mild Glomerular Disease
BP: every 6 months
GFR/CrCl: yearly
Proteinuria: yearly
Reasons for Cystitis
UTI
Pyelonephritis
Non-infectious
STI-Male
Pathogenesis of Cystitis
Colonization of the vaginal introits from fecal flora
Ascension to the bladder via the urethra
Can ascend to the kidneys (pyelonephritis)
Most Common Pathogens in Microbiology
E. coli (75-90%)
Proteus
Klebsiella
Clinical Presentation of UTI
Dysuria Frequency Urgency Suprapubic pain Hematuria
Clinical Presentation of Pyelonephritis
Symptoms of cystitis may or may not be present Chills Flank pain with CVA tenderness N/V Appears ill
Diagnostic Tests for Cystitis
UA
Positive leukocyte esterase +/- nitrites
Consider urine culture with sensitivities
Diagnostic Tests for Pyelonephritis
UA
Urine culture & sensitivities
Treatment of Cystitis in Women
Nitrofurantoin
Bactrim
Fosfomycin
Phenozopyridine (Pyridium)
Differential for Men with Cystitis
Prostatitis
Urethritis secondary to STI
Urinary tract abnormality
Nephrolithiasis
Treatment of Cystitis in Men
Trimethoprim-sulfamethoxazole (Bactrim)
Fluoroquinolone
Outpatient Treatment for Pyelonephritis
Mild to moderate illness
Fluoroquinolone resistance low: Cipro or levoquin
Other: Bactrim or Augmentin
Inpatient Treatment for Pyelonephritis
Oral fluoroquinolone + aminoglycoside
Extended spectrum cephalosporin
Symptoms of Non-infectious Cystitis
Similar to cystitis with nocturne
Pressure in pelvis
Irritants of Non-infectious Cystitis
Bubble baths Feminine hygiene sprays Tampons Spermicidal jellies Chemoradiation Foods: tomatoes, artificial sweeteners, caffeine & chocolate
Work-up of Non-infectoius Cystitis
UA
Urine culture
Sometimes cystoscopy
Treatment of Non-infectious Cystitis
Avoiding irritants
Voiding routine
Kegel’s
Manifestations of Chlamydia in Males
Urethritis: symptomatic or asymptomatic
Epididymitis
Prostatitis
Diagnosing Chlamydia in Males
NAAT testing
Treatment of Chlamydia
Azithromycin
Rocephin
Presentation of Gonorrhea in Males
Symptomatic urethritis
Epididymitis: age
Diagnosing Gonorrhea in Males
NAAT testing
Treatment of Gonorrhea
Azithromycin
Rocephin
Presentation of Overactive Bladder Without Incontinence
Urgency
Frequency
Nocturia
Pathophysiology of Overactie Bladder Without Incontinence
Detruser muscle contracts irregularly at small volumes
Usually idiopathic
Can be secondary to DM, stroke, spinal disease