Bladder and Kidney Cancer Flashcards
Bladder cancer (urothelial cancer)
- Malignant cancers of the urothelium
- Multifocal
- Highly invasive
- Most urothelial cancers occur in the bladder
Bladder cancer: risk factors
- Cigarette smoking
- Exposure to dyes/toxins
- Phenacetin containing analgesics
- Radiation therapy
- Cyclophosphamide (Cytoxan)
- Chronic recurrent stones• Chronic lower urinary infections
- Indwelling catheters
Bladder cancer S/S:
▫ Hematuria
▫ Dysuria
▫ Frequency
▫ Urgency
BC: DX
- Urinalysis: gross or microscopic hematuria.
- Bladder wash specimen and bladder biopsy.
- IV urogram, CT, MRI.
BC: surgical management
• Cystectomy
- Radical surgery plus intravesical chemotherapy
• Transurethral resection or fulguration
Cystectomy : partial
▫ Resection of the portion of the bladder wall containing the tumor
along with a portion of normal tissue
Complete cystectomy
▫ Involves the removal of:
Bladder, prostate, and seminal vesicles
Bladder, uterus, cervix, urethra, and the ovaries
Transurethral resection or fulguration
▫ Used for the diagnosis and treatment of superficial lesions
▫ Used to control bleeding
▫ Tumor mass is excised
▫ The remaining portion of the tumor are cauterized
Ileal conduit
▫ Ureters are surgically placed in the ileum, Urine is collected in a
pouch
▫ Continent reservoirs or “neobladders” are being used
Uterosigmodoistomy
- Diverts urine to the large intestine, so no stoma is required
- Client excretes urine with bowel movements
Neobladder
internal reservoir created from part of the small intestine ; because it is connected to the urethra , the patient can learn to void normally.
BC: Nonsurgical management
• Radiation Therapy
• Chemotherapy
• Intravesical Therapy:
- Prophylactic immunotherapy with instillation of bacille Calmette Guerin (BCG)
Radiation therapy (local)
• Used with cystectomy • May be used as the primary therapy • Can be combined with systemic chemotherapy Typical side effects: ▫ Inflammation of the rectum ▫ Incontinence ▫ Skin irritation
Chemotherapy (systemic)
1. Chemotherapy drugs: ▫ Cisplatin (Platinol) ▫ Vinblastin (Velban) ▫ Doxorubicin (Adriamycin) ▫ Methotrexate 2. Successful in prolonging life 3. Rarely results in a cure
Chemotherapy side effects
▫ Alopecia ▫ Anemia ▫ Thrombocytopenia (low platelet count ) ▫ Mucositis ▫ Bruising/Excessive bleeding ▫ Neutropenia ( low count of WBC)