Bipolar disorders Flashcards

1
Q

Key feature of bipolar disorders?

A
  • Periods of mania alternate with periods of depression
  • Emotional roller- coaster: elation to despair to elation to despair…
  • “Manic depression” = old name for bipolar disorders
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2
Q

Manic episode (DSM-5 definition)

A

A distinct period of abnormally and persistently elevated, expansive or irritable mood and abnormally and persistently increased goal-directed activity or energy, lasting at least 1 week and present most of the day, nearly every day (or any duration if hospitalization is necessary)

3 or more of the following (4 if mood is only irritable):
 Inflated self-esteem or grandiosity
 Decreased need for sleep
 Atypically talkative
 Flight of ideas or subjective experience of racing thoughts
 Distractibility as reported or observed
 Increase in goal-directed activity (socially, at work, or sexually) or psychomotor agitation (purposeless non-goal-directed activity)
 Excessive involvement of activities with a high potential for painful consequences (e.g., unrestrained buying sprees, sexual indiscretions, foolish business investments)

The mood disturbance is sufficiently severe to cause a marked impairment in social or occupational functioning

  • OR necessitates hospitalization to prevent harm to self or others
  • OR there are psychotic features

Not substance induced

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3
Q

Manic episode : at least 3 of following…

A

 Inflated self-esteem or grandiosity
 Decreased need for sleep
 Atypically talkative
 Flight of ideas or subjective experience of racing thoughts
 Distractibility as reported or observed
 Increase in goal-directed activity (socially, at work, or sexually) or psychomotor agitation (purposeless non-goal-directed activity)
 Excessive involvement of activities with a high potential for painful consequences (e.g., unrestrained buying sprees, sexual indiscretions, foolish business investments)

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4
Q

Hypomanic episode DSM 5 criteria

A

Same as manic episode BUT

  • Lasting at least 4 consecutive days vs. at least 1 week
  • Episode is NOT severe enough to caused a marked impairment in social/occupational functioning or necessitate hospitalisation; NO psychotic features

+ Disturbance in mood or functioning is unequivocal and observable by others

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5
Q

What are the three main categories of bipolar disorders?

A
  • Bipolar 1: manic episodes, typically alternating with MDEs
  • Bipolar 2: Hypomanic episodes (which must be) alternating with MDEs
  • Cyclothymia: Hypomanic symptoms (not episodes) alternating with hypodepressive symptoms
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6
Q

Bipolar 1 diagnostic criteria?

A
  • At least one manic episode; but over 90% have recurrent episodes
  • MEs typically alternate with MDEs
  • Manic symptoms can by psychotic, but typically not
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7
Q

Bipolar 1 prevalence?

A

12 month prevalence - 0.6% in USA

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8
Q

Bipolar 1 typical onset?

A

~18 years

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9
Q

Bipolar 1 length of mood episode?

A

2-6 months

- Rapid cycling: 4 or more mood episodes in previous 12 months (2 or more ‘cycles;

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10
Q

Bipolar 2 criteria?

A
  • Hypomanic episodes alternate with MDEs

- Approx 15% of bipolar 2 -> bipolar 1

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11
Q

Bipolar 2 prevalence?

A

12 month prevalence - 0.8% in USA

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12
Q

Bipolar 2 typical onset?

A

Mid 20s

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13
Q

Bipolar 2 length of mood episode?

A
  • Tend to be shorter

- More likely to be rapid cycling

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14
Q

Cyclothymia?

A

Recurrent periods of hypomanic symptoms alternating with hypodepressive symptoms, over at least a 2 year period

  • Criteria for manic, hypomanic, and MDEs have never been met

Chronic, low-level symptoms

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15
Q

Cyclothymia prevalence/ onset?

A

0.4% - 1% in USA; adolescence / early adulthood

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16
Q

Bipolar disorder - suicide?

A
  • Bipolar 1 patients 15x suicide rate of general population
  • Greater risk than MDD
  • Particular risk when coming off a ME
17
Q

Chen and Dilsaver 1996 suicide attempts

A

Control: 4.2%
Unipolar (MDD): 16%
Bipolar 1: 29-30%