Biology of the B cell

Question 1

Where does the B cell start

Answer 1

Bone marrow

Question 2

What is the first stage of B-cell maturation

Answer 2

Pro-B cells

Question 3

All B cells express what classification determinant

Answer 3

CD19

Question 4

Pro-B cells become what, how

Answer 4

Pre-B cell, expression of pre-B cell receptor on membrane, VDJ recombination occuring

Question 5

T/F: Pre B-cells can create IgM and IgD

Answer 5

False: Can only create IgM

Question 6

Pre-B cells become what

Answer 6

Immature B cells

Question 7

What occurs in at the immature B cell level

Answer 7

recombination of heavy and light chain genes complete, express surface IgM as part of B cell Receptor

Question 8

B cell Receptor

Answer 8

tell the cell that the antibody has bound something

Question 9

Central tolerance

Answer 9

process of eliminating developing B or T lymphoctes that react to self antigens

Question 10

What are the ways central tolerance occurs

Answer 10

Apoptosis, anergy, clonally ignorant

Question 11

anergy

Answer 11

cell fails to respond to antigen

Question 12

clonally ignorant

Answer 12

cell not activated by antigen, low density of B cell receptors, signally is impaired

Question 13

T/F: Apoptotic immature B cells never leave the bone marrow

Answer 13

True

Question 14

T/F: In checking for self tolerance there can be another round of light chain gene recombination to select a new J chain. There will not more Central Tolerance testing after this occurs

Answer 14

False: There will be more central tolerance testing to see if there is reactions to self antigens

Question 15

B cells mature at what secondary lymphoid tissues

Answer 15

lymph nodes, tonsils, spleen, peyer’s patches, and MALT

Question 16

T- helper cells do what when recognition and binding of MHC-II peptide complex occurs

Answer 16

produce CD40Ligand (co-stimulatory factor)that will bind to CD40 on B cell, produce cytokines

Question 17

B cells do what after being activated

Answer 17

Proliferate, somatic hypermutation, class switch recombination

Question 18

Activated B cells become

Answer 18

Plasma cells, memory B cells

Question 19

Memory B cells are formed where

Answer 19

Germinal centers following primary infection

Question 20

T/F: Memory B cells last many years

Answer 20

True

Question 21

What is the function of memory B cells

Answer 21

express antibody on cell surface but do not secrete, generate an accelerated and more robust antibody-mediated immune response in the case of re-infection

Question 22

What is the function of Plasma cells

Answer 22

produce large quantities of antibody

Question 23

T/F: Plasma cells are clonally derived from their progenitor and make the same antibody

Answer 23

True

Question 24

T/F: Plasma B cells last many years

Answer 24

False: Plasma B cells last days/months

Question 25

What organs are germinal centers, function

Answer 25

lymph nodes and spleen, sites of somatic hypermutation and class switch recombination

Question 26

Proliferal tolerance

Answer 26

Central tolerance in germinal centers