Biological Flashcards
Outline the initiation of smoking via the reward system (biological addiction)
- reward system activated when smoking
- NAChRs triggered
- Nicotine binds to NAChRs
- dopamine released
- memory created, making the individual crave the affect of dopamine
Outline the initiation of smoking via genes (biological addiction)
- gene influence the use of tobacco by 39-80%
- Commings et al (1996) = A1 variation in the DRD2 gene. Smokers = 48% likely to have this gene, non-smoker = 25%
- Nobel et al (2000) = the A1 variation of the DRD2 gene is the reward gene - fewer dopamine receptors (lacks pleasurable experiences)
Outline the maintenance of smoking (biological addiction)
Chronic exposure leads to a reduction of activity in the reward pathway (down regulation). The more it’s taken, the less the affect on dopamine. Taken to avoid discomfort
Outline the relapse of smoking (biological addiction)
Pre-frontal cortex becomes less affected in chronic drug users, especially with decision making and judgement. Xian found genetic factors accounted for 54% of quitting failures
Outline initiation of gambling (biological addiction)
- Shah (2005) = gambolling transmitted genetically in males
* Black (2006) = first degree relatives were more likely to inherit the gene
Outline the maintenance of gambling (biological addiction)
- Zuckerman (1979) = individual differences, sensation seeking theory
- Bonnaire et al (2007) = chronic gamblers scored higher on sensation seeking questionnaires
Outline relapse of gambling (biological addiction)
Rosenthal and Lesieur (1992) found gamblers seek the thrill, boredom avoidance
Evaluation points of the biological model? (Biological addiction)
- diathesis stress model
- stigmatisation
- use of family studies
- cause and effect between smoking and PFC
What is addiction? (Biological addiction)
A state that may occur when consuming substances or participation in an activity that leads to excessive use disrupting everyday functioning