Biochemistry: Genetics

Question 1

Inhibitors of transcription:

Binds to the beta subunit of bacterial DNA-dependent RNA polymerase

Answer 1

Rifampicin

Question 2

Inhibitors of transcription:

Binds to the DNA template and interferes with the movement of RNA polymerase during transcription

Answer 2

Dactinomycin

Question 3

Inhibitors of protein synthesis:

Bind to the 30S subunit and interferes with initiation

Answer 3

Streptomycin

Aminoglycosides

Question 4

Inhibitors of protein synthesis:

Prevents binding of aminoacyl-tRNA to the A site

Answer 4

Tetracycline

Question 5

Inhibitors of protein synthesis:

Inhibits prokaryotic peptidyltransferase

Answer 5

Chloramphenicol

Question 6

Inhibitors of protein synthesis:

Binds to the 50S subunit and inhibits translocation

Answer 6

Clindamycin

Macrolides