Biochemistry - Drosophilia Genetic Control Flashcards
How can gene-differentiation interactions be identified?
Studying abnormalities
Early stages of development in drosophilia…
The Earliest stages of development are done-so in the oocyte, where mutations can affect development plan, being maternal-effect genes
Maternal Genes
Genes whose product are produced or deposited into the oocyte.
Where are zygotic genes important?
Embryo functioning developmental genes
What do zygotic genes do?
These interpret/respond to the positional information laid out in the egg by the maternal-effect gees
Pattern in drosophilia.
Segementation of 14 denticles, marking the basic insect body plan of 3 thoraic segments, 8 abdominal segments and three head segments
Parasegments
Consist of posterior region of one segment and the anterior region of another.
Four types of segmentation genes…
Co-ordinate Genes
Gap genes
Pair-rule genes
Segment-polarity genes
Co-Ordinate Genes
Determine co-ordinate axis of the embryo, that is the anterior-posterior axis and the dorsal-ventral axis.
How do the co-ordinate genes define the axis?
Polarity and gradients
What is anterior/head and thorax formation regulated by?
Bicoid gene
Bicoid Genes
Morphogens control embryonic gene expression by transcriptional activation and translational repression.
What is the product of the bicoid gene?
A TF for anterior-structure genes, produced by nurse cells, exported to anterior region of the oocyte
Mechanisms of bicoid…
Helix-turn-helix domain invades the DNA grooves, the genes activated containing upstream regions.
How can bicoid be regulatied?
Differences in two nucleotides can regulate bicoid affinity