Biochemistry

Question 1

site of steroid synthesis in cells

Answer 1

smooth ER

Question 2

steroid producing cells contained well developed…

Answer 2

smooth ER

Question 3

mild hyperglycemia worsen with pregnancy

Answer 3

glucokinase deficiency or mutation

Question 4

what synthesis is susceptible to folate deficiency

Answer 4

de novo thymidine

Question 5

elevated alanine and lactate caused by which enzyme deficiency

Answer 5

Pyruvate dehydrogenase

Question 6

Where repressor binds in operon

Answer 6

operator

Question 7

citric acid cycle step of energy generation

Answer 7

Succinyl CoA–> Succinate makes GDP–> GTP

Question 8

thiamine cofactor for which enzymes

Answer 8

pyruvate dehydrogenase, alpha ketoglutarate dehydrogenase, branched chain alpha keto acid dehydrogenase, transketolase

Question 9

metabolism of pyruvate with O2 vs with none

Answer 9

O2: pyruvate to acetyl CoA via pyruvate dehydrogenase in glycolysis to oxidative phosphorylation.
no O2: pyruvate converted to lactate by lactate dehydrogenase.

Question 10

porphyrin ring = ___ + ____

Answer 10

glycine + succinyl CoA

Question 11

Vitamin K is the cofactor for which enzyme

Answer 11

gamma glutamyl carboxylase

Question 12

fx of gamma glutamyl carboxylase

Answer 12

catalyze post translational modifications of vit K dependent proteins.

Question 13

dry ulcerated skin on knees and elbows. small gray plaques on conjunctiva

Answer 13

vit a (retinol) deficiency

Question 14

first enzyme of glycolysis

Answer 14

hexokinase

Question 15

PKU during pregnancy

Answer 15

strict restriction

Question 16

fx of DNA polymerase 1 in bacteria

Answer 16

removes RNA primers from 5’ to 3’ in Okazaki fragments, only one with 5’-3’ exonuclease activity

Question 17

mental retardation, hepatosplenomegaly, foam cells, cherry red spot, neuro defects

Answer 17

Niemann Pick

Question 18

MOA of cipro

Answer 18

DNA gyrase inhibitor

Question 19

glc, lactate, and pyruvate of von Gierke

Answer 19

low glc and high lactate and pyruvate

Question 20

all 3 prokaryotic DNA polymerases have ____ activity

Answer 20

3’ to 5’ exonuclease