Biochem 79

Question 1

Which drug inhibits Na/K ATPase by binding to the K site?

Answer 1

Ouabain

Question 2

Cardiac glycosides directly inhibit what? Which lead to indirect inhibition of what?

Answer 2

Na/K ATPase.

Na/Ca exchange -> increased intracellular Calcium

Question 3

Type 1 Collagen is found where? (7)

Answer 3

1) Bone
2) Skin
3) Tendon
4) Dentin
5) Fascia
6) Cornea
7) Late wound repair

Question 4

Type II Collagen is found where? (3)

Answer 4

1) Cartilage
2) Vitreous Body
3) Nucleus Pulposis

Question 5

Type II Collagen is found where? 5

Answer 5

1) Reticulin - skin
2) Blood vessels
3) Uterus
4) Fetal tissue
5) Granulation tissue

Question 6

Type IV collagen is found where?

Answer 6

1) Basment membrane
2) Basal Lamina
3) Lens

Question 7

Vascular type of Ehlers-Danlos syndrome is caused by a deficiency of what type of Collagen?

Answer 7

Type III

Question 8

Type 4 collagen is defective in what syndrome?

Answer 8

Alport

Question 9

Type 4 collagen is targeted by autoantibodies in what syndrome?

Answer 9

Goodpasture

Question 10

Which collagen is affected in Osteogenesis Imperfecta type I?

Answer 10

Type I