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First Aid Drugs > Biochem > Flashcards

Biochem Flashcards

1
Q

Tetracycline

A

Bind prok 30S and block aminoacyl tRNA from entering the acceptor site

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2
Q

Aminoglycosides

A

Bind prok 30S and inhibit formation of initiation complex and cause misreading of mRNA

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3
Q

Chloramphenicol

A

Binds euk 50S and inhibits peptidyl transferase

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4
Q

Macrolides

A

Bind euk 50S and prevent release of uncharged tRNA after it has donated its AA

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5
Q

Hydroxyurea

A

Inhibits ribonucleotide reductase (no UDP to dUDP)

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6
Q

6-MP

A

Blocks de novo purine synthesis (no PRPP to IMP)

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7
Q

5-FU

A

Inhibits thymidylate synthase (no dUMP to dTMP)

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8
Q

Methotrexate

A

Inhibits dihydrofolate reductase (no DHF to THF so no dUMP to dTMP)

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9
Q

Trimethoprim

A

Inhibits bac dihydrofolate reductase (no DHF to THF, so no dUMP to dTMP)

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10
Q

Fluoroquinolones

A

Inhibit DNA gyrase (prok topoII)

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11
Q

Mebendazole/thiabendazole

A

Act on microtubules; antihelminthic

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12
Q

Griseofulvin

A

Act on microtubules; antifungal

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13
Q

Vincristine/vinblastine

A

Act on microtubules; anti-cancer

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14
Q

Paclitaxel

A

Act on microtubules; anti-breast cancer

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15
Q

Colchicine

A

Act on microtubules; anti-gout

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16
Q

Ouabain

A

Inhibits Na/K pump by binding K+ site

17
Q

Cardiac glycosides (digoxin and digitoxin)

A

Directly inhibit Na/K ATPase, causing indirect inhibition of Na/Ca exchange so there’s more Ca in cell and more heart contractility

18
Q

Fomepizole

A

Inhibits alcohol DH and is antidote for methanol or ethylene glycol poisoning

19
Q

Disulfiram (Antabuse)

A

Inhibits acetaldehyde DH (EtOH –> acetaldehyde –> acetate); so acetaldehyde accumulates –> hangover sx

20
Q

Electron transport inhibitors

A 
Rotenone (complex I)
Antimycin A (complex III)
Cyanide, CO (complex IV)
21
Q

ATP synthase inhibitor

A

Oligomycin, prevents ATPsynthase from working

22
Q

Uncoupling agents

A

2,4-DNP, aspirin, thermogenin in brown fat

Stop ATP syn but allow e- transport -> heat

First Aid Drugs (13 decks)

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