Biliary Tract Flashcards
____ converges to form the RT and LT hepatic duct?
Intrahepatic Bile Duct
The RT and LT hepatic ducts join to form the _____
Common Hepatic Duct (CHD)
Where is the GB located?
Inferior end of Main lobar fissure
The GB neck tapers to form the ___ ?
Cystic duct
The cystic duct joins with what?
CHD
What Cystic duct and the CHD form the ___ ?
CBD
What CBD and the main panc duct form the ___?
Ampulla of vater
What is another name for the pancreatic duct?
Duct of Wirsung
What does the Portal triad consist of ?
MPV, CHD, PHA.
What do sonographers refer to the portal triad as?
Mickey mouse
What supplies the GB?
Cystic artery
Where does the cystic artery branch from?
RHA
What is the GB divided into?
Neck, Body, Fundus.
What is a spiral fold which controls bile flow in the cystic duct.
Valve of Heister’s
What is an ABNL sacculation (diverticulum) of the neck of the GB?
Hartmann’s pouch
Where is the phrygian cap located?
A fold between the body and fundus of the GB
Where is a junctional fold in the GB?
Between the body and the neck (infundibulum) of the GB
The GB passes posterior to the ___ and ___ and then joins the main ___ at the ___.
Duodenum and Panc Head
Panc duct at the ampulla of vater
Where does the Ampilla of vater empties through and is what is it controlled by?
Duodenal papilla
Sphincter of Oddi
What is a NL wall thickness?
<3mm
What can cause GB wall thickening?
Cholecystitis
Hypoalbuminemia
Ascities
Hepatitis
CHF
Pancreatitis
What are the 3 types of jaundice?
Pre hepatic, Hepatic, Post Hepatic
What is Pre-Hepaic jaundice caused by?
Excessive red cell breakdown
What happens if the liver excessively breaks down red cells?
The liver becomes overwhelmed and the liver cant conjugate bilirubin = unconjugated hyperbilirubinemia
What is Hepatic jaundice caused by?
There is a dysfunction in the liver itself. The liver cant conjugate bilirubin
What is Post-Hepatic jaundice?
Obstruction of the biliary tree
What does an obstruction in the biliary tree cause?
- what does that result in?
Conjugated hyperbilirubinemia
- pale stool and dark urine
What are examples of biliary obstruction?
Choledocholithiasis
Choledochal cyst
Cholangiocarcinoma
Biliary atresia
Panc carcinoma
GB carcinoma
Carolis dz
Mirizzi syndrome
What is calcium bilirubinate granules and cholesterol crystals?
Sludge
What is non shadowing, echogenic material which layers shift with patient position?
Sludge
Sludge is associated with what ?
Biliary stasis
What is sludge is secondary associated to?
Cholecystitis
Cystic duct obst.
Prolonged fasting
Parenteral nutrition (intravenous feeding)
Hemolysis
What does long term parenteral nutrition (TPN) cause ?
GB stasis-> sludge, milk of calcium or stones
What is tumefactive sludge?
Thick sludge that appears as an intraluminal GB mass
What is cholelithiasis?
GB stone
What is a GB filled with stones and may be seen as a strong shadow in the RUQ?
WES- wall echo shadow
or
Double arc
What is Acute cholecystitis?
Inflammation of the GB due to obst of the cystic duct
What is the murphy’s sign?
Tenderness d/t transducer pressure over GB area
What are complications of acute cholecystitis?
Empyema
Gangrenous cholecystitis
Perforation
Pericholecystic abscess
What is chronic cholecystitis?
Reoccurring symptoms of biliary colic d/t multiple episodes of acute cholecystitis
what is the difference sonographicly of an acute vs chronic cholecystitis?
Does not appear different
What is emphysematous cholecystitis ?
Acute cholecystitis d/t GB wall ischemia and infection
Emphysematous cholecystitis occurs more commonly in what kind of patients?
Diabetic patients
What is gas produced by in emphysematous cholecystitis?
Anerobic bacteria (clostridium E. coil)
What does gas look like in the GB?
Comet tail or ring down artifact
What is referred to as the champagne sign?
Gas bubbles to the nondependent wall of the GB
What does gangrenous cholecystitis result in?
Pneumoperitoneum peritonitis and sepsis
What causes gas in the biliary system?
Emphysematous cholecystitis
GB fistula
Choledochojejunostomy
Sphincter of Odii papilotomy
ERCP
What is a choledochojejunostomy?
Creating an anastomosis of the CBD to the jejunum to relieve biliary obst.
What is empyema of the GB?
The GB fills with purulent material (pus)
GB perforation is a ____ and ____ complication of acute cholecystitis
Rare
Life threating
What are complications of a perforated GB?
Peritonitis
Pericholecystitis
Biliary fistula
What is acalculous cholecystitis
Acute cholecystitis without gallstones
Sonographic findings:
in the GB you see wall thickening, Murphy sign, and pericholecystic fluid
Acalculous cholecystitis
What is Milk of calcium bile (limy bile)
Sludge like material with high concentration of calcium
What is milk of calcium bile associated with?
Chronic cholecystitis and GB obst. of the cystic duct
What is a porcelain GB?
Calcification of the GB wall
What is Porcelain GB associated with?
Chronic Cholecystitis
A porcelain GB is linked with what?
Cancer
What is a hydrops of the GB?
- what is another name for this?
Overdistended GB
Mucocele of the GB
What is the measurement for a hydropic GB?
> 5cm in Trans
What is hydropic GB associated with ?
Kawasaki dz
Acute febrile illness-> multiorgan vasculitis
What measurement is unlikely to be cancerous in a GB polyp?
<10mm
What measurement is likely to be cancerous in a GB polyp?
> 10mm
What is the malignancy rate for a GB poylp?
Between 37% - 88%
What is cholesterolosis?
Lipis are deposited in the GB wall
Cholesterolosis can sonographicly look like what?
Polpys
What is another name for cholesterolosis?
Strawberry GB
What are the clinical symptoms of cholesterolosis
Usually silent but can cause colicky ABD pain
What is the survival rate of GB carcinoma?
- how is it found?
5year less than 5%
usually diagnosed post cholecystectomy. <50% preoperatively
What is adenomyomatosis?
Hyperplastic changes in the GB wall causing overgrowth of the mucosa
Sonographic finding:
GB: hyperechoic foci with thickened GB wall (comet tail artifact)
Adenomyomatosis
Where are the majority of biliary Obst. located?
Distal CBD
What are the most common reasons for Biliary Obst?
GB and Carcinoma of the Panc head
What is the NL, equivocal, and Dilated measurements for the CBD?
NL <5 mm
Equivocal 6 to 7mm
Dilated >8 mm
What is the CBD measurement rule with age?
1 mm per decade
Increases with age
10mm upper limites
What is the normal measurement for a post cholecystectomy patient?
Up to 10mm
Wha is the parallel channel sign or shotgun sign of the liver?
Dilated intrahepatic ducts
What is cholecystokinin ?
Hormone that is released into the blood by the ingestion of fatty foods -> causes the GB to contract
With a fatty meal what is a negative and positive sign of the duct?
Neg- duct unchange or decreases
Post- duct increases
Where is a distal CBD Obst?
Outside usually a stone
it includes the GB
Where is a common hepatic Obst?
Only the common Hepatic ducts and intrahepatic ducts with dilate. GB will be contracted
Where is a Obst at the Junc Hepatic ducts?
At the junc of the RT and LT hepatic ducts
GB will be contracted
What is choledocholithiasis ?
Gallstones in the bile ducts
What are symptoms of choledocholithiasis?
Biliary colic (RUQ pain) and jaundice
What lab values are increased with choledocholithiasis?
ALP, Conjugated bilirubin, GGT
What is Mirizzi syndrome?
Extrahepatic biliary Obst. from and impacted stone in the cystic duct causing extrinsic mechanical compression of the CHD
Mirizzi syndrome is associated with what findings?
Intrahepatic duct dilatation, cystic duct stone, curved seg stenosis of CHD, Cholecystocholedochal fistula
What is Cholangiocarcinoma?
Bile duct adenocarcinomas
Where is Cholangiocarcinoma usually found?
Extrahepatic bile ducts (CHD or CBD)
What is Klatskin tumor?
- where is it located?
Cholangiocarcinoma
hepatic hilum (RT and LT intrahepatic duct) but not extrahepatic biliary dilation
What is Biliary ascariasis ?
- what can it block?
Parasitic roundworm Ascaris Lumbricoides
ampulla vater or main panc duct
Where is Ascariasis commonly encountered?
South East Asian countries
What is cholangitis
Inflammation of the biliary tree.
What is the classical triad of cholangitis?
RUQ pain, Fever, and Jaundice
What are the types of cholangitis?
Acute bacterial cholangitis
AIDS cholangitis
Recurrent pyogenic cholangitis
Sclerosing cholangitis
What is the most common cause of cholangitis?
Choedocholithiasis
What lab work is increased with cholangitis?
COnjugated bilirubin
ALP
GGT
Amylase and Lipase
White blood cells (leukocytosis)
When is biliary atresia suspected?
Jaundice (hyperbilirubinemia) last longer than 14 days
What ducts arent affected with biliary atresia?
Absence of extrahepatic bile ducts (CBD and CHD)
What is biliary atresia associated with sonographicaly?
Triangular cord sign
What is the triangular cord sign?
Echogenic triangular structure anterior to the PV
Polyspenia **, absent IVC, sinus inversus/ambiguous, cardiac anomalies (ASD/VSD) is associated with what?
Biliary Atresia
What is the treatment for Biliary Atresia?
Kasai portoenterostomy (KPE)
If done within 90 days of life.
What is Pneumobilia?
Air in the biliary tract
Pneumobilia is associated with what?
ERCP ( endosopic retrograde cholangiopancreatogram)
What causes pneumobilia?
ERCP
Sphincter of Oddi papillotomy
CHoledochojejunostomy
GB fistula
Emphysematous cholecystitis
What causes choledochal cyst?
Congenital bile duct cystic dilation of the ectrahepatic ducts
Sonographic findings
Bile duct has two cystic structure in the RUQ (GB and dilated CBD) intrahepatic bile duct dilatation
Chholedochal cyst
Where is choledochal cyst more prevent in?
Asia
-before the age 10.
What is Caroli DZ/ Caroli syndrome?
Congenital anomaly of the intrahepatic ducts that have multi segment dilation
How do you get caroli dz/syndrome?
- associated with?
Generally inherited
- Congenital fibrosis, Auto Recessive Poly Kid dz, Portal HTN
Sonographic findings:
in the bile ducts you see multi cystic structures from the porta hepatis to bile ducts. May see sludge and calculi in the ectatic ducts that can cause acoustic shadowing
Caroli DZ/syndrome
Pancreatic adenocarcinoma can cause what to the bile duct and GB?
Obst. of the biliary tree
Ciurvoiser GB
What is the double duct sign?
- casue
Dilation of the CBD, Duct of wursung.
Panc carcinoma
What is primary Sclerosing Cholangitis (PSC)
Inflammation and fibrosis of the intra and extra hepatic bile ducts
PSC can lead to __ of the liver?
Liver TX
What lab vaules are incresed with PSC?
ALP, GGT, ALT/AST, Conjugated
Sonogrpahic findings:
The bile duct walls are thick and the PT has Cirrhosis?
PSC
What is Primary Biliary Cholangitis (PBC)?
Autoimmune disorder resulting in cholestasis due to destruction of the small intrahepatic ducts leading to cirrhosis
what lab values are increased with PBC?
ALT, AST, APLP, GGT, AMAs
What is done to rule out blockage of the bile ducts?
Ultrasound
What is the end product of hemoglobin breakdown?
Bilirubin
What is total bilirubin?
Conjugated + unconjugated bilirubin
What is conjugated bilirubin?
Process of removing protein (albumin) from unconjugated bilirubin making it soluble.
What is important for bilirubin disposal?
Conjugation
What is unconjugated hyperbilirubinemia resulted from?
Impaired hepatic bilirubin uptake
Impaired conjugation bilirubin
Increase bilirubin production
What are is Impaired hepatic bilirubin?
CHF, liver varices, TIPS, drugs, Contrast agents
What is Impaired conjugation bilirubin
Gilbert syndrome
Crigler-Najjae syndrome type I and II
What is Increase bilirubin production?
Hemolysis/ ineffective erythropoiesis
Do the kidneys filter conjugated or unconjugated bilirubin?
Conjugated
NOT unconjugated bc its bound to albumin
What does conjugated Hyperbilirubinemia result from?
Direct bile outflow
What is Alkaline Phosphate ALP
An enzyme that is concentrated in the bile ducts (also bone, liver, placenta)
ALP increases with what pathology?
Bile duct obst. ANY BILE OBST.
(bone growth and pregnancy)