Benzodiazepines Flashcards
1
Q
What is the longest acting benzo?
A
Diazepam
2
Q
What is the shortest acting?
A
Alprazolam
3
Q
Which benzo is more likely to cause CNS toxicity?
A
Alprazolam
4
Q
Which rarely cause significant toxicity?
A
Zopiclone
5
Q
Whats the MOA?
A
Bind to GABAa Receptors and enhance chloride channel opening
6
Q
How are they metabolised?
A
Hepatic metabolism - many active metabolites
7
Q
What’s the antidote?
A
Flumazenil 0.1mg IV
8
Q
When should the antidote be avoided?
A
Chronic benzo use
Can precipitate withdrawal seizures
9
Q
Antidote indications?
A
Reversal in benzo-naive patient to prevent intubation or if excessive sedation has occurred
e.g. elderly patient not for intubation!
