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Toxicity of this city > Baclofen > Flashcards

Baclofen Flashcards

1
Q

What is the therapeutic index of Baclofen?

A

Narrow
>200mg = significant CNS toxicity

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2
Q

What are the clinical signs of Baclofen OD?

A

Agitation -> coma
Seizures
Hypotonia
Areflexive
Resp depression

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3
Q

What is the mechanism of action?

A

Synthetic GABA analogue

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4
Q

How can patients appear in significant overdose?

A

Braindead with fixed dilated pupils, areflexia and hypotonia

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5
Q

Treatment?

A

Supportive
IV benzos for seizures

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6
Q

Treatment for OD in setting of intrathecal baclofen pump?

A

Stop infusion
Empty reservoir
LP - remove 30-50ml of CSF

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Toxicity of this city (11 decks)

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