Benign Pathology and Breast Changes

Question 1

Most common diffuse breast disorder?

Answer 1

Fibrocystic change

Question 2

Exaggeration of normal proliferative and involutional changes. Likely related to a predominance of estrogen and progesterone is what?

Answer 2

Fibrocystic change

Question 3

Clinical features of fibrocystic change?

Answer 3

• Women 35-55
• breast pain
• multiple breast lumps
• varies with menstrual cycle
• occasional nipple discharge
• regress after menopause

Question 4

What is the result of an obstruction of the extralobular duct by epithelial proliferation or fibrosis?

Answer 4

Simple cyst

Question 5

A milk filled retention cyst associated with lactation?

Answer 5

Galactocele

Question 6

During lactation, bacteria can enter through a crack in the nipple which allows bacteria to enter a breast duct and occlude the duct orifice. What is this called?

Answer 6

Puerperal (lactational mastitis)

Question 7

What is referred to as plasma cell mastitis, chronic mastitis or mammary duct ectasia depending on the stage or histologic findings present?

Answer 7

Periductal Ectasia

Question 8

What type of mastitis typically effects peri and postmenopausal women?

Answer 8

periductal mastitis

Question 9

Descriptive term that can be associated with a variety of conditions. Silicone is a common cause for this?

Answer 9

Granulomatous Mastitis

Question 10

Thrombophlebitis of the superficial veins of the anterior breast and chest is what?

Answer 10

Monder’s disease

Question 11

Localized trauma to breast can cause focal hemorrhage and liquefaction of breast fat leading to what?

Answer 11

Fat necrosis

Question 12

Most common benign solid tumor?

Answer 12

Fibroadenoma

Question 13

Overgrowth of connective and glandular tissue within a lobule that is an estrogen induced breast tumor?

Answer 13

Fibroadenoma

Question 14

Variants of fibroadenoma?

Answer 14

Complex fibroadenoma and juvenile fibroadenoma

Question 15

Rapidly growing mass during pregnancy and lactation in response to hormones?

Answer 15

Lactating (secretory) adenoma

Question 16

What grows within a major lactiferous duct near areola, not in TDLU?

Answer 16

Intraductal papilloma

Question 17

Most common cause of spontaneous bloody nipple discharge?

Answer 17

Intraductal papilloma

Question 18

What features of a papillary lesion are more suspicious for cancer?

Answer 18

> 1.5 cm with in duct, expands duct, or extends into branching ducts.

Question 19

What carries a higher risk for cancer than a solitary, central, large duct papilloma?

Answer 19

Multiple peripheral papillomatosis

Question 20

Adolescent women with multiple small cysts in a Swiss-cheese appearance. Up to 28% of patients have positive family history of breast cancer?

Answer 20

Juvenile papillomatosis

Question 21

An overgrowth of adipose tissue encased by a thin connective tissue capsule?

Answer 21

lipoma

Question 22

Uncommon, localized overgrowth of fibrous, epithelial, or adipose tissues that lacks a true capsule?

Answer 22

Hamartoma

Question 23

Focal accumulation of dense stroll fibrous tissue. TDLU’s are atrophic, obliterated, or underdeveloped?

Answer 23

Focal fibrosis

Question 24

Disorders in collagen metabolism area feature of diabetes?

Answer 24

Diabetic mastopathy

Question 25

Focal overgrowth of stroll connective tissue, thought to be related to progesterone stimulation?

Answer 25

Pseudoangiomatous stromal hyperplasia (PASH)

Question 26

Tends to develop in pre and postmenopausal women takin estrogen-progesterone HRT?

Answer 26

PASH

Question 27

Thought to arise from Schwann’s cells of the peripheral nerves and rarely develops in breast?

Answer 27

Granular cell tumor (GCT)