Benign Pathology and Breast Changes Flashcards

1
Q

Most common diffuse breast disorder?

A

Fibrocystic change

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2
Q

Exaggeration of normal proliferative and involutional changes. Likely related to a predominance of estrogen and progesterone is what?

A

Fibrocystic change

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3
Q

Clinical features of fibrocystic change?

A
  • Women 35-55
  • breast pain
  • multiple breast lumps
  • varies with menstrual cycle
  • occasional nipple discharge
  • regress after menopause
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4
Q

What is the result of an obstruction of the extralobular duct by epithelial proliferation or fibrosis?

A

Simple cyst

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5
Q

A milk filled retention cyst associated with lactation?

A

Galactocele

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6
Q

During lactation, bacteria can enter through a crack in the nipple which allows bacteria to enter a breast duct and occlude the duct orifice. What is this called?

A

Puerperal (lactational mastitis)

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7
Q

What is referred to as plasma cell mastitis, chronic mastitis or mammary duct ectasia depending on the stage or histologic findings present?

A

Periductal Ectasia

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8
Q

What type of mastitis typically effects peri and postmenopausal women?

A

periductal mastitis

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9
Q

Descriptive term that can be associated with a variety of conditions. Silicone is a common cause for this?

A

Granulomatous Mastitis

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10
Q

Thrombophlebitis of the superficial veins of the anterior breast and chest is what?

A

Monder’s disease

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11
Q

Localized trauma to breast can cause focal hemorrhage and liquefaction of breast fat leading to what?

A

Fat necrosis

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12
Q

Most common benign solid tumor?

A

Fibroadenoma

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13
Q

Overgrowth of connective and glandular tissue within a lobule that is an estrogen induced breast tumor?

A

Fibroadenoma

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14
Q

Variants of fibroadenoma?

A

Complex fibroadenoma and juvenile fibroadenoma

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15
Q

Rapidly growing mass during pregnancy and lactation in response to hormones?

A

Lactating (secretory) adenoma

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16
Q

What grows within a major lactiferous duct near areola, not in TDLU?

A

Intraductal papilloma

17
Q

Most common cause of spontaneous bloody nipple discharge?

A

Intraductal papilloma

18
Q

What features of a papillary lesion are more suspicious for cancer?

A

> 1.5 cm with in duct, expands duct, or extends into branching ducts.

19
Q

What carries a higher risk for cancer than a solitary, central, large duct papilloma?

A

Multiple peripheral papillomatosis

20
Q

Adolescent women with multiple small cysts in a Swiss-cheese appearance. Up to 28% of patients have positive family history of breast cancer?

A

Juvenile papillomatosis

21
Q

An overgrowth of adipose tissue encased by a thin connective tissue capsule?

A

lipoma

22
Q

Uncommon, localized overgrowth of fibrous, epithelial, or adipose tissues that lacks a true capsule?

A

Hamartoma

23
Q

Focal accumulation of dense stroll fibrous tissue. TDLU’s are atrophic, obliterated, or underdeveloped?

A

Focal fibrosis

24
Q

Disorders in collagen metabolism area feature of diabetes?

A

Diabetic mastopathy

25
Q

Focal overgrowth of stroll connective tissue, thought to be related to progesterone stimulation?

A

Pseudoangiomatous stromal hyperplasia (PASH)

26
Q

Tends to develop in pre and postmenopausal women takin estrogen-progesterone HRT?

A

PASH

27
Q

Thought to arise from Schwann’s cells of the peripheral nerves and rarely develops in breast?

A

Granular cell tumor (GCT)