Behcet’s Disease & Sjogren's syndrome Flashcards
What is Behcet’s Disease?
Systemic vasculitis of unknown cause. Thought to be autoimmune
What ethnicities are more likely to be effected by Behcet’s disease?
Turks
Japanese
Mediterraneans
How does Behcet’s disease present?
Recurrent oral ulcers Recurrent genital ulcers Anterior/Posterior uveitis Erythema Nodosum Diarrhoea Colitis Non erosive large joint arthropathy CN palsy
What investigations can be done in a patient with suspected Behcet’s disease?
Skin test - needle prick -> papule formation
What is the treatment for Behcet’s disease?
Immunosuppressants eg Ciclosporin, Methotrexate
What are the two classifications of Sjogren’s disease?
Primary - Females more than makes, 40s/50s
Secondary - RA, SLE, SS
What is Sjogren’s syndrome?
Autpimmune destruction of glands that secrete fluids causing inflammation and reduced production
What are the features of Sjogren’s syndrome?
Decreased tear production
Decreased saliva production
Bilateral parotid swelling
Vaginal dryness
What autoantibiodies are raised in Sjogren’s syndrome?
RF
ANA
ENA - Ro, La
What are some of the systemic features of Sjogren’s syndrome?
Polyarthritis Raynauds Bibasal pulmonary fibrosis Vasculitis Myositis
What conditions are associated with Sjogren’s syndrome?
Autoimmune - Thyroid disease, Primary biliary sclerosis, Autoimmune hepatitis
What investigations can be done for a patient with suspected Sjogren’s syndrome?
Schirmer tear test (Hold litmus paper up to eye and see how much is absorbed)
Bloods for antibodies - ANA, ENAs - Ro, La, RF
Parotid gland biopsy
Hypergammaglobulinaemia
What is the managment of Sjogren’s syndrome?
Artificial tears Saliva replacements NSAIDs Hydroxychloroquine for arthralgia Immunosuppression if severe systemic disease
What is Mixed connective tissue disease?
An autoimmune disorder which has the combined features of SLE, SS, RA, Polymyositis
RNP antibiodies - marker
