ANCA negative vasculitidies

Question 1

What is Henoch-Schonlein Purpura (HSP)?

Answer 1

Inflammation of small blood vessels causing increased permeability and leaking
Most commonly occurs in children - IgA nephropathy varient

Question 2

What are the symptoms of Henoch-Schonlein Purpura (HSP)?

Answer 2

Commonly occurs after an URTI
A rash with numerous small bruises
Colicky abdominal pain
Arthralgia
Haematuria

Question 3

What is the treatment of Henoch-Schonlein Purpura (HSP)?

Answer 3

usually resolves in 4-6 weeks without any lasting complications
Symptomatic relief eg NSAIDs
May need corticosteroids if severe

Question 4

What is Goodpasture’s syndrome?

Answer 4

Anti-glomerular basement membrane antibodies attack healthy collagen in the lungs and kidneys causing basement membrane breakdown and renal damage (Rapidly progressing glomerulonephritis)

Question 5

What are the symptoms of Goodpasture’s syndrome?

Answer 5

Haemoptysis
Proteinuria
Haematuria
SOB
Oedema

Question 6

What investigations can be done in a patient with suspected Goodpasture’s syndrome?

Answer 6

Dipstick - Haematuria, Proteinuria
CXR - Bilateral lower zone haemorrhages
ANCA -ive

Question 7

What is the treatment for Goodpasture’s syndrome?

Answer 7

Very rapidly progressing

Immunosuppresion eg prednisolone + plasmapheresis