Behçet's Disease

Question 1

What is Behçet’s disease?

Answer 1

A complex inflammatory condition that characteristically presents with recurrent oral and genital ulcers.

Question 2

Genetic Component of Behçet’s Disease.

Answer 2

HLA-B51 (Prognostic Indicator).

Question 3

Differential Diagnoses of Mouth Ulcers (7).

Answer 3

1. Simple Aphthous Ulcers.
2. IBD - Crohn’s.
3. Coeliac Disease.
4. Vitamin Deficiency - B12, Folate, Iron.
5. Herpes Simplex.
6. Hand, Foot and Mouth - Coxsackie A.
7. Squamous Cell Carcinoma.

Question 4

Oral Features of Behçet’s Disease.

Answer 4

At least 3 episodes of mouth ulcers annually - painful, sharply circumscribed erosions with red halo that heal over 2-4 weeks.

Question 5

Genital Features of Behçet’s Disease.

Answer 5

Similar to oral ulcers.

Kissing Ulcers - 2 opposing surfaces so they are facing each other.

Question 6

Dermatological Features of Behçet’s disease (3).

Answer 6

1. Erythema Nodosum.
2. Papules/Pustules (like Acne).
3. Vasculitic Type Rash.

Question 7

Ophthalmological Features of Behçet’s Disease (3).

Answer 7

1. Uveitis.
2. Retinal Vasculitis.
3. Retinal Haemorrhage.

Question 8

Investigations of Behçet’s Disease (2).

Answer 8

1. Clinical Diagnosis.
2. Pathergy Test : Sterile needle to create a SC abrasion on forearm. Check 24-48 hours later for a weal 5mm or more in size.