Behaviorial Flashcards
1
Q
When can you hospitalize against will?
- 2 conditions
A
- Danger to other, to self, or disability to inhibit ability to perform functions of daily living
2
Q
IQ
- stanford binet
- Weschler
- mean
- IQ <70
- IQ < 40
- IQ <20
A
- mental age/ chronologic age * 100
- scale, use test, 6 verbal, 5 performance
- 100 w/ SD of 15
- intellectual disability
- severe disability
- profound disability (will need full time care)
3
Q
Delirium vs dementia
- onset, consciousness, memory, course, prognosis
A
- Delerium is acute onset, impaired conciousness, global memory impaired, fluctuating, reversible
- Dementia is gradual, concious, remote memory spared (can tell you about wedding / birth of children), progressive decline, irreversible
4
Q
Amnesia
- anterograde
- retrograde
- kosakoff
A
- inability to create new memories
- cannot remember anything from before accident
- thiamine def, destruction mamillary bodies, both antero and retro grade amnesia
5
Q
Bipolar
- Valproic acid
- Lithium
- Carbamazepine
A
- block Na channel and increase GABA
- MOA unknown
- GABA agonist, stabilizes Na channels
6
Q
Biogenic Amine Theory
- what is it
- importance
- educating patients
A
- depression is caused by decrease of monoamines, serotonin NE, and dopamine
- all drugs are aimed at elevating monoamines
- takes 6-8 wks to reach potential
7
Q
SSRI
- MOA
- OCD and panic disorder
- anxiety and depression
- adverse dysfunction
- what makes serotonin
A
- block serotonin reuptake
- sertraline, paroxetine
- citalopram, fluoxetine
- sex dysfunction, sedation, suicidal ideation
- tryptophan
8
Q
SNRI
- MOA
- examples that cause liver and kidney damage
- examples that increased BP and tachy
A
- inhibit NE and Serotonin reuptake
- Venlafaxine, Duloxetine,
- Desvenlafaxine
9
Q
Atypicals
- buproprion
- mirtazapine
- Vilazodone
- Nefazadone and Trazodone
A
- block dopamine and NE reuptake; short half half, no sex side effects,
- alpha 2 blocker, highly sedative and no sex dysfunction, but does cause weight gain
- SSRI that does not have sex side effects
- 5HTA and HT1 antagonist; N is hepatotoxic, and trazadone causes priaprism (persistenet, painful erection)
10
Q
TCA
- MOA
- amitryptiline
- amoxapine
- clomipramine
- despramine
- imipramine
- protriptyline
- heart effects
A
- block reuptake of NE
- highly sedating
- off label schizo
- OCD, sedative
- less sedating than others in class
- enuresis (bed wetting in children) in children
- least sedative
- quinidine life effects -> QRS and QT prolongation -> give hypertonic Na Bicarb
11
Q
Mono-amine oxidase Inhibitors
- MAO
- Tranylcypromine
- Selegeline
- tyramine: what is it, what does it do, what can it cause,
A
- stops breakdown of serotonin, dopamine, etc
- hepato tox, overdose can cause seizures
- prevents breakdown of dopamine, helpful w/ parkinsons
- mono-amine that is naturally produced and causes large release of catecholamines; HTN crisis, neck stiffness, N/V, tachy and stroke; found in cheese and wine
12
Q
serotonin syndrome
- caused by
- sxs
- tx
- malignant hyperthermia: mutation, chrom, what happens, trigger, sxs, precaution, tx
A
- combination of SSRI and MAOI
- hyperthermia, hyperreflexia, tremor, clonus, HTN, mydriasis, diarrhea, hyperactive bowel
- sedation, intubation, 5-HT blockade
- AD, on chrom 19, problem w/ ryanodine receptor on sarcoplasmic reticulum, triggered by anesthetics and caffeine, products cause release of lots of CA from SR -> causing massive release of heat; make sure to ask every pt if they or their family have ever had problems w/ anesthesia, dantrolene
13
Q
Switching Between diff antidepressants
- SSRI to SSRI
- SSRI to TCA
- switching to/from MAOI:
A
- start new SSRI at equivalent or lower dose
- cross taper, decrease SSRI while increasing TCA
- taper drug, stop for two weeks and then restart
14
Q
Main Problems with Drugs
- Sedation
- Ortho hypotension
- GI distress
- Weight gain
A
- give to pts with insomnia and have them take at night; fluoxetine, paroxetine, mirtaapine, trazadone, amitryptilene
- take this at night, phenelzine, amitryptyline
- take with food; citalopram,
- imipramine, clomipramine, paroxetine
15
Q
Prognosis for psych disorders
- favorable
- unfavorable
A
- acute, good insight
- chronic, no insight
16
Q
MDD
- epi
- what is it
- caused by
- serotnin location
- sleep
- sex
- hunger
- DDX
- tx
- refractory depression
A
- females in 40s
- pts get repeated bouts of depression, need episodes of 2 weeks that are separated by at least 2 months
- decreased serotonin and NE
- serotonergic neurons are found in raphe nuclei of brainstem
- serotonin important for sleep/wake cycle -> have sleep disturbances
- low libido
- can increase or decrease hunger,
- dysthmia (chronic, mild depression), cyclothymia (cycling between mood elevation and depression w/ normal period in between), bipolar, hypothyroidism, bereavement
- SSRI and CBT
- electroconvulsive therapy -> short term memory loss
17
Q
Grief
- sxs same as depression
- sxs diff from depression
- tx
A
- sad, sleep disturbances, poor appetite
- sx wax and wane, lower suicide risk, sx can last while but will eventually get back to normal
- therapy
18
Q
Kubler Ross Dying Stages
- what are the stages
- do they have to go in order
A
- denial, anger, bargaining, depression (SIGECAPS), acceptance
- no, and can go back and forth
19
Q
Depression
- DX
- other needs
- what is SIGECAPS
A
- must see 5 or more of SIGECAPS for at least 2 weeks and depressed mood or loss of interest
- needs to cause significant distress or impairment in social, occupational, or other areas
- sleep disturbances, loss of interest, feelings of guilt, loss of energy, loss of concentration, change in appetite, psychomotor retardation, suicidal ideation
20
Q
Risk for Suicide
- SAD PERSONS
A
- sex (male), age (older), depression, previous attempt (#1), ethanol use, lack of rational thought, sickness, organized plan, no spouse, social support lacking
21
Q
Depression and Insomnia
- tx
A
- SSRI and trazadone (5HT2A blocker)
22
Q
Dysthmic Disorder
- Dx
- diff from MDD
A
- Shows less than 5 SIGECAPS for 2 consecutive years
- if they go to 5 or more SIGECAPS for 2 weeks or more during that time then considered MDD
23
Q
Post Partum Blues
- epi
- sx
- tx
A
- 50-85%, starts 2-3 days after birth and resolves w/i 10 days
- tearfulness, fatigue, depressed, affect, irritable
- reassurance, watchful waiting
24
Q
Post Partum Depression
- range
- epi
- reoccurence
- sxs
- tx
- meds, importance
A
- mild to severe (life threatning to mother and baby)
- 10% women
- 25%
- SIGECAPS
- mild: therapy, severe: hospitalization
- sertraline, paroxetine, nortryptilene (can be given while breast feeding)
25
Q
Post partum psychosis
- epi
- time frame
- sxs
- tx
A
- 0.1 - 0.2 %
- in first 3 months
- schizo affect, delusions, hallucination, disorganized behavior
- antipsychotics or antidepressants w/ hospitalization
26
Q
Bipolar
- what is it
- mania (DIG FAST)
- type 1: characterized by, time frame, occurence
- type 2: characterized by, time frame, occurence
- cyclothymia: what is it, occurs
- rapid cycling: what is it, caused by
- DDX when in mania
- what happens when given anti-depressant
- tx: mani pts, acute;y, long term
- lithium: possible MOA, side effects, pregnancy
- inositol depletion hypothesis
A
- alternating bouts of depression and manic phases
- distractibility, insomnia, grandiosity, flight of ideas, activity/agitation increased, speech pressured (talk and move fast), throughtlessness
- manic episodes (lasting at least 1 wk up till 13 wks, with 1/2 cycles per year) w/ or w/o depressive episodes
- hypomania (last less than 1 week) to full blown depression (lasts at leat 2 weeks); 1/2 cycles per year
- hypomanic w/ low levels of depression; last for 2 years, symptom free for no more than 2 months, can turn into bipolar
- at least 4 episodes of depresion/mania over 12 month period; antidepressants
- cocaine use, amphetamine use, schizo, personality type II disorder
- it will drive them into manic phase
- hospitalize mani pt, benzo as sedative then start mood stabilizer, lithium
- decreased NE and increase serotonin; can cause kidney tox; ebstein anomaly (low tricuspid with small right ventricle
- overactive inositol signal tranduction pathway can be attributeed to mania and lithium can prevent the overactivity.
27
Q
Drug induced mania
- which drugs
- signs
- dx
- tx: acute, long-term
A
- cocaine and amphetamines
- mania, tachycardia, HTN, pupillary dilation, arrythmia, ischemia (MI in young pt)
- urine tox screen, serum tox screen
- CCB, drug tx
28
Q
Schizo
- epi
- dx
- schizopheniform
- brief psych disorder
- schizoaffective
- positive sxs: most common, loss of ego boundaries, thought blocking, neologisms, word salad, loose associations, echolalia, perseveration
- negative sxs
- DDX: delerium
- DDX- drugs
A
- late teen to early 20s
- 2 or more positive sxs (delusions, hallucination, disorganized behavior, disorganized speech) longer than 6 months
- sxs for 1-6 months
- sxs less than a month
- mood disorder (2 weeks of bipolar, or depression) + schizophenia
- hallucination, delusions, loss of ego boundaries (invade your personal space), thought blocking (stop talking bc listening to voices), neologisms (inventing new words), word salad (uttering unconnected and unrelated words or phrases), loose association (when talking once sentence to next barely correlate with eachother), echolalia (repeat everything you say), perseveration (say ame thing over and over again)
- lack of emotional affect, loss of interest in life, poverty of speech
- in pts with underlying dx, pt not oriented, waxes and wanes, resolves once primary problem fixed
- LSD & PCP (visual, taste, touch, olfactory hallucinations), Cocaine and amphetamine (paranoid delusions and formication), anabolic steroid, corticosteroid (pyschosis in form of bizzare disturbing dreams and mood disturbances)
29
Q
Hallucinations
- what is it
- auditory: what is it, seen in
- visual: what is it, seen in
- olfactory: what is it, seen in
- tactile: what is it, seen in, formication
A
- false sensory perception
- hears things, most common in schizo
- seeing things, linked to drugs
- smelling things, caused by brain lesion (temporal) or seizure disorder
- feels thing, EtOH withdrawal, bugs crawling
30
Q
Delusion
- what is it
A
- fixed, false belief despite facts against them