BB U5 Terms

Question 1

Endogenous sources

Answer 1

intracellular, shipping internal proteins – ANCs

Question 2

Exogenous sources

Answer 2

extracellular, anything that is not you – B lymphs and APCs

Question 3

Autologous

Answer 3

self donation

Question 4

Syngeneic

Answer 4

twin donation

Question 5

Allogeneic

Answer 5

other person donation

Question 6

Xenogeneic

Answer 6

different species donation

Question 7

GvHD

Answer 7

host system no longer exists and the WBCs in the graft grows to kill everything in host

Question 8

HvGD

Answer 8

host kills the graft and therefore the host needs a replacement graft

Question 9

T cell mediated

Answer 9

CD8 cytotoxicity against organ cells with different proteins on cells surface

Question 10

Antibody mediated

Answer 10

B cell recognition and antibody production against foreign antigens

Question 11

NK cell mediated

Answer 11

MHC I allorecognition with KIR facilities cytotoxic effects on foreign tissue

Question 12

Hyper acute

Answer 12

pre-existing antibodies, minutes to days

Question 13

Acute

Answer 13

CD4 and CD8 mediated, 1-2 weeks

Question 14

Chronic

Answer 14

CD4 and B cell responses, 3 mth – 10 yrs

Question 15

Hydros fetalis

Answer 15

edema in fetus/neonates

Question 16

Icterus gravis

Answer 16

jaundice

Question 17

Erythroblastosis fetalis

Answer 17

immature RBCs in circulation

Question 18

Placental

Answer 18

a barrier between fetus and mother’s circulation, exchanges O2, nutrients, waste products

Question 19

Kernicterus

Answer 19

accumulation of bilirubin in CNS

Question 20

Amniocentesis

Answer 20

bilirubin tested for ΔA450 on Liley graph

Question 21

Cordocentesis/PUBS

Answer 21

very invasive with 1-2% mortality rate, punctures near where umbilical cord enters the placenta

Question 22

DAT

Answer 22

diagnoses HDFN after birth

Question 23

Elution

Answer 23

removes antibodies from surface of RBCs

Question 24

Cord hemoglobin

Answer 24

indicates anemia and RBC

Question 25

Cord bilirubin

Answer 25

indicator for need of exchange transfusion and the presence of kernicterus

Question 26

Phototherapy

Answer 26

UV light breaks apart bilirubin

Question 27

Transfusion

Answer 27

small quantities of blood returns hemoglobin level to normal

Question 28

Exchange transfusion

Answer 28

reconstituted whole blood will be exchanged for infant’s circulated blood

Question 29

IVIG

Answer 29

treats hyperbilirubinemia

Question 30

RhoGAM

Answer 30

passive anti-D

Question 31

Candidate requirements for RhoGAM

Answer 31

Rh neg mom Non-immunized (no sensitization to anti-D Rh neg mom Rh neg moms with Rh pos babies After invasive procedures like those who have miscarriages, abortions, ectopic, and amniocentesis

Question 32

Non-candidates include

Answer 32

Rh neg moms with Rh neg babies Rh neg moms who already have a real anti-D Rh pos moms

Question 33

Fetal screen

Answer 33

detects Rh pos

Question 34

Positive rosette

Answer 34

>3 clumps per field

Question 35

Negative rosette

Answer 35

loose tumbleweed red cells

Question 36

Keilhauer-Betke Test (KB)

Answer 36

quantitates how many fetal cells (Hgb F) are in mom's circulation

Question 37

Fetal hemoglobin

Answer 37

bright pink cells

Question 38

Mother/adult cells

Answer 38

light pink "ghost cells"

Question 39

Immune hemolytic anemia

Answer 39

shortens the RBC survival mediated by immune responses

Question 40

Alloimmune

Answer 40

immune system stimulated by foreign antigens made from corresponding hemolyzed antibodies, leads to transfusion reactions and hemolytic disease

Question 41

Autoimmune

Answer 41

can be warm or cold autoantibodies, where autoantibodies can be directed against their own antigen red cells

Question 42

Drug-induced

Answer 42

making antibodies to a particular drug or drug complex, but in turn, damages the patient’s red cells

Question 43

Warm autoadsorption

Answer 43

adsorbs out the antibody at 37 C using ZZAP or chloroquine diphosphate

Question 44

Drug adsorption mechanism

Answer 44

anti-drug antibody reacts to drug on RBC in vivo

Question 45

Immune complex

Answer 45

absorbed onto RBC surface

Question 46

Membrane modification

Answer 46

drugs alter RBC membrane and absorb all proteins in nonspecific manner

Question 47

Unknown mechanism/random

Answer 47

makes autoantibodies that recognize RBC antigens