BB - Day 3 Flashcards
Kell low frequency antigen(s)
Kp(a)
Js(a)
-both can be ruled out by single heterozygous crossout
Lutheran low frequency antigen(s)
Lu(a)
- also an IgM = clinically insignificant
- can be ruled out by single heterozygous crossout
Can M and N antigens be destroyed by enzymes? Can S and s antigens be destroyed by enzymes?
Yes
- sits on outer edge of glycoprotein
- easily destroyed by enzymes
Variable
-antigens further down glycoprotein, less accessible
anti-M and anti-N antibodies belong to what class of antibodies? Do they bind complement?
IgM mostly
-cold reactive
Do not bind complement
-clinically insignificant
anti-S and anti-s antibodies belong to what class of antibodies? Do they bind complement?
IgG
Yes
-hemolytic transfusion reactions
This ANTIGEN varies in strength in adults
P1 antigen
-only antigen in the P group
anti-P1 antibodies belong to what class of antibodies?
IgM
-reactive at 4C
Does P1 antibody cause HDFN?
No
- IgM antibody, but antigen is poorly developed
- clinically insignificant
I blood group - are I and i antigens antithetical? Where can each antigen be found?
No
Babies have little i at birth
-up to 18 months, then decrease
Adults have big I
-trace amounts of little i
anti-I antibodies belong to what class of antibodies?
IgM
- cold auto-antibody
- clinically insignificant
anti-k (little k) is also called…
Cellano
What are the antithetical Kell group antigens?
K and k
Kp(a) and Kp(b)
Js(a) and Js(b)
Can Kell be denatured by enzymes?
No - no effect
-reaction strength stays the same
This antigen is the second highest in immunogenicity after D antigen
K
- Kell antigens are highly immunogenic
- multiple transfusions increase incidence
anti-K antibodies belong to what class of antibodies?
IgG
- AHG by IAT (Coombs)
- clinically significant
- K requires two heterozygous crossouts to rule out