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CLS 790 > BB - Blood Components & Donor Selection > Flashcards

BB - Blood Components & Donor Selection Flashcards

1
Q

The label print on a blood component bag must be in this color

A

Black and white

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2
Q

What are the end results from doing a slow spin and a hard spin on whole blood?

A

Slow spin = packed RBCs (pRBC), platelet rich plasma (PRP; platelet concentrate)

Hard spin = packed RBCs, fresh frozen plasma (FFP), cryoprecipitate (CryoPP), cryosupernatant (Cryosuper; plasma cryoprecipitate reduced)

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3
Q

Whole blood units contain these 3 components

A

Red cells
White cells
Platelets (in plasma)

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4
Q

Whole blood and RBC/RBC-LR - storage temp and shelf life for units that were never frozen? How much longer can they be stored with an additive?

A

1-6C for 35 days (CPDA-1)
-ACD, CPD, CP2D - 21 days

42 days (1 more week)

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5
Q

What is the dosage bump for a 70kg adult given 1 unit of whole blood/RBC/RBC-LR?

A

hct increase 3%

hgb increase 1 g/dl

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6
Q

If a RBC unit is broken during processing, what is the new shelf life?

A

24 hours

  • must be transfused within this time
  • new expiration date/time must be on label and records
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7
Q

What is in a RBC-LR unit?

A

Red cells with white cells reduced

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8
Q

Frozen RBCs contain this additive to prevent them from rupturing when frozen… Once thawed, the unit is called…

A

Glycerol

Deglycerolized RBCs
-glycerol removed and saline added

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9
Q

Frozen RBCs need to be stored at what temperature? Shelf life? Once thawed, they need to be kept at this temperature and has this shelf life…

A

-65C or below

10 years

1-6C for 24 hrs

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10
Q

What is the dosage bump for a 70kg adult given 1 unit of thawed (deglycerolized) RBCs?

A

hct increase 3%
hgb increase 1 g/dl

-same as other units

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11
Q

FFP needs to be prepared and frozen within… FFP contains…

A

8 hours of whole blood phlebotomy

Plasma proteins
All coagulation factors
-poor in platelets (use platelet-rich plasma instead)

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12
Q

FFP/FP24/PF24RT24 - storage temp and shelf life for frozen units? Storage temp and shelf life for thawed units?

A

-18C or below for 1 year

1-6C for 24 hours

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13
Q

What are FP24 and PF24RT24?

A

FP24 = Whole blood and plasma prepared and FROZEN within 24 hours of phlebotomy; stored in fridge within 8 hours of phlebotomy

PF24RT24 = apheresis plasma prepared within 24 hours after phlebotomy. Held at room temp up to 24 hours after phlebotomy

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14
Q

Cryoprecipitated antihemophilic factor (AHF; cryo) - contents?

A

Cold insoluble precipitate from thawed FFP

-rich in Factor VIII, XIII, vWF, fibrinogen

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15
Q

Cryoprecipitated antihemophilic factor (AHF; cryo) - storage temp and shelf life for frozen units? Storage temp and shelf life for thawed units?

A

-18C or below for 1 year

Room temp for 6 hours, or 4 hours if pooled

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16
Q

Plasma cryoprecipitate reduced (cryosuper) - contents? How long can it be kept out before being refrozen? Frozen at what temp?

A

Residual plasma from cryoprecipitate production

  • deficient in Factor VIII, Factor XIII, vWF, fibrinogen
  • has other clotting factors

24 hours

-18C or colder

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17
Q

Difference between the contents of AHF cryo and cryosuper?

A

AHF cryo is rich in Factor VIII, XIII, vWF, fibrinogen whereas cryosuper is deficient in those proteins
-cryosuper still has other clotting factors

18
Q

Cryosuper - storage temp and shelf life for frozen units? Storage temp and shelf life for thawed units?

A

-18C or below for 1 year

1-6C for 5 days

19
Q

Platelets - storage temp and shelf life? Platelets storage require ___ to ensure platelets are oxygenated and CO2 is expelled

A

20-24C (room temp), 5 days

Agitation

20
Q

Platelets - for an adult, how many bags are needed? Alternative?

A

5-6 concentrates (PLT, PLC)
-1 concentrate = 10 kg body weight

1 single donor platelets; platelet pheresis (SDP, PP)

21
Q

Platelets - what is the dosage increase from concentrate and from platelet pheresis?

A

5,000-10,000/ul

30,000-60,000/ul

22
Q

Granulocytes - contents. Storage temp and shelf life

A

Concentrated leukocytes
-very rarely ordered

20-24C (room temp), transfuse ASAP within 24 hours of collection

23
Q

Purpose of irradiation? Prevents what disease?

A

Stops WBC proliferation

Prevents GVHD in immunodeficient patients

24
Q

Irradiated components - shelf life and temp

A

28 days from irradiation, but not more than original expiration date (ie platelets expire in 5 days)

Original component’s storage temp

  • RBCs = 1-6C
  • platelets = room temp
25
Q

What 2 components does pathogen reduction technology (PRT) treat?

A 
Platelets
Plasma
-reduce levels of pathogens
-viruses, bacteria, parasites, WBC (alternative to irradiation)
-important for babies
26
Q

Patients experiencing systemic anemia, trauma, surgery are given units of…

A

Whole blood

RBC/RBC-LR

27
Q

Patients experiencing bleeding disorders, burns, shock are given units of…

A

Platelet rich plasma (PRP)

28
Q

Patients experiencing hemophilia or von Willebrand Disease are given units of…

A

Cryoprecipitate

29
Q

Patients experiencing cancer treatment, organ transplant, or surgery are given units of…

A

Platelets

30
Q

Patients experiencing infections are given units of…

A

Granulocytes

-last resort

31
Q

Required blood tests upon blood donation (3)

A

ABO - forward, reverse

Rh typing - DAT, IAT for weak D

Antibody screen

32
Q

Febrile reactions are best treated by giving units of…

A

RBC-LR

-white cells cause febrile reactions

33
Q

It is possible to restore levels of 2,3-DPG and ATP in red cells stored in CPDA-1 solution by adding a solution containing

A

Rejuvenating solution (Rejuvasol) containing pyruvate, inosine, phosphate, and adenine

34
Q

Why must rejuvenated red cells be washed?

A

Wash rejuvenated cells with 2 liters of 0.9% saline solution to remove the inosine, which may be toxic to patients

35
Q

What does platelet additive solution (PAS) do? What does it mitigate?

A

Replace portion of plasma

Lowers risk of allergic transfusion reactions (TRALI)

36
Q

Required blood tests to detect these pathogens/diseases…

A 
Syphilis
Hepatitis
HIV
Chagas (Trypanosoma cruzi)
Zika virus
West Nile virus
HTLV I and II
37
Q

Donor criteria regulated by these organizations (4)

A

FDA
AABB
State of California
School Districts

38
Q

Must be over this age and weight to donate blood

A

> 17 years
At 16, requires parental consent

> 110 pounds

39
Q

How often can the following components be donated: whole blood, double reds/2RBC, platelet pheresis, plasma pheresis

A

Whole blood = 2 months (8 weeks)

Double reds = 4 months (16 weeks)

Platelets = 48 hours (2 days)

Plasma = 48 hours (2 days)

40
Q

This type of vaccine has a deferral period but this other type does not

A

Deferral = live attenuated

No deferral = toxoid, synthetic, killed/inactivated

41
Q

Blood diseases/infections that are permanent deferments (5)

A 
HIV
Hepatitis
Malaria
Bebesiosis
Chagas' disease

CLS 790 (13 decks)

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