Basic GI Pharmacology Checkpoint Questions

Question 1

1) Why don’t rifaxamin and fidamoxicin have greater systemic toxicity?
2) How do they work?

A) Humans lack cell walls; inhibits transpeptidase, which prevents further elongation and cross-linking of cell wall peptidoglycans
B) Very little is absorbed when taken orally; bacteria lack a nuclear membrane; inhibits RNA polymerase
C) Blocking mRNA changes human DNA

Answer 1

B

Question 2

Fidamoxicin is active against gram positive aerobes and anaerobes - has no activity against gram negative bacteria. Name another antibiotic with this activity.

A) Gentamicin
B) Amoxi clav
C) Vancomycin
D) Co-trimoxazole

Answer 2

C

Question 3

How does loperamide (Imodium) work?

A) Acts on the opioid receptor to increase colonic transit time and decrease peristalsis
B) Inhibits secretion of gastric hormones
C) Prostaglandin synthesis inhibition and inactivation of enterotoxins
D) Decrease diarrhea caused by excess fecal bile acids

Answer 3

A

Question 4

How does bismuth subsalicyclate (pepto bismol) work?

A) Acts on the opioid receptor to increase colonic transit time and decrease peristalsis
B) Inhibits secretion of gastric hormones
C) Prostaglandin synthesis inhibition and inactivation of enterotoxins
D) Decrease diarrhea caused by excess fecal acids

Answer 4

C