bacteriostatic Inhibitors of protein synthesis

Question 1

Tetracyclines - MOA

Answer 1

inhibit protein synthesis

Question 2

Tetracyclines - spectrum

Answer 2

broad spectrum - Gram+ and -, rickettsia, sprirochetes, brucella, chlamydia, mycoplasma, H. pylori, anthrax,

Question 3

Tetrocyclines - uses

Answer 3

1st line for ricketts, Rocky Mountain Spotted fever, trachoma, lymphogranuloma, brucellosis, cholera, Mycoplasma PNA, Lyme disease, anthrax, H.Pylori, acne

Question 4

Doxycycline and minocycline - uses

Answer 4

periodontal disease

Question 5

Tetrocyclines - AE

Answer 5

Gi disturbance (give with food, but it decreases absorption; dose at bedtime)
yellowing of teeth
superinfection
hepatic and renal toxicity
photosensitivity

Question 6

Tetrocyclines - Interactions

Answer 6

should not be given with Ca, Fe, MG, or Al

Question 7

Tetrocyclines - Precautions

Answer 7

• kidney disease

- don’t give in pregnancy, or children under 8

Question 8

Macrolids - drugs

Answer 8

erythromycin, azithromycin, and clarythromycin

Question 9

Macrolids - MOA

Answer 9

bacteriostatic (can be bacteriocidal for susceptible organisms), broad spectrum

Question 10

Macrolids - Uses

Answer 10

most gram + and some gram -; 1st choice for diptheria, , can be used as an alternate

Question 11

Macrolilds - AE

Answer 11

one of the safest drugs, QT prolongation and mild GI disturbance;

Question 12

Macrolids - interactions and contraindications

Answer 12

• do not use in patients with congenital QT syndrome
• do not use with CYP3A4 drugs and certain Ca channel blockers
• do not use with theophylline, carbamazepine, and warfarin

Question 13

Clinda- MOA

Answer 13

bacteriostatic inhibitor of protein synthesis

Question 14

Clinda - spectrum

Answer 14

gram + and - anaerobic and most gram -aerobes

Question 15

Clinda - uses

Answer 15

1st choice for severe group A strep and gas gangrene

Question 16

Clinda - interactions

Answer 16

do not use with erythromycin or chloramphenicol