bacterial virulence Flashcards

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1
Q

describe the relationship between the microbe and the host

A

symbiosis - to live together

relations can be beneficial for both host and microbe or harmful to the host

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2
Q

describe Mutualism

A

most beneficial,
both members benefit
in some cases they need each other to survive

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3
Q

define Commensalism

A

one benefits without affecting the other

although host benefits it may not be apparent

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4
Q

define Parasitism

A

a parasite benefits from its host while harming it.

the most harmful

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5
Q

name the 2 types of indigenous microbiota

A

resident and transient

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6
Q

why would transient bacteria leave

A

competition from other microbes,
elimination by the body immune system,
chemical or physical changes in the body

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7
Q

describe resident microbiota

A

most ‘personal’
specifically adopted to live in our body
unique to each individual
one of the main functions - compete out foreign bacteria

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8
Q

what bacteria is specifically adapted to live in our body

A

resident

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9
Q

under normal circumstances will microbiota cause disease

A

no.

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10
Q

certain circumstances can make microbiota …

A

opportunistic pathogens

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11
Q

what circumstances can change microbiota into opportune pathogens

A

immune supression
antibiotics
the wrong location

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12
Q

describe acquisition of normal microbiota

A

foetus free of microbiota
as soon as water breaks mouth and nose get microbiota from birth canal
intestine from first meal
skin from doctors, nurses, mother

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13
Q

when is resident microbiota established on a baby

A

within first few months

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14
Q

define pathogenicity

A

ability to cause disease

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15
Q

define virulence

A

a measure of pathogenicity

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16
Q

define infection

A

invasion of the body by pathogens

17
Q

describe virulence factors

A

variety of factors that interact with a host and an able the pathogen to enter, adhere, gain access to nutrience and escape detection by immune system

18
Q

name the 5 events in infection

A
  1. exposure to pathogen
  2. adherence to skin/mucosa
  3. invasion through epithelium
  4. cononisation and growth
  5. tissue damage and disease
19
Q

describe the mucus membrane

A

main portal of entry
line all exposed body cavities
thin, moist warm with living cells

20
Q

describe adhesions

A

attachment to cells
found in fimbrae and flagella
some bacteria will colonise a site forming a biofilm

21
Q

describe ligand

A

surface lipoproteins or glycoprotein that bind to cell receptors. called adhesions in bacteria