Bacterial structure Flashcards

1
Q

lag phase

A

no increase in cell number due to adaptation

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2
Q

log (exponential phase)

A

active and uniform growth

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3
Q

Stationary phase

A

growth and death balance because food runs out which makes peptides signal to stop growing

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4
Q

Death phase

A

cells die rapidly

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5
Q

clinical significance of stationary phase?

A

stationary phase cells are resistant to some cell wall antibiotics

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6
Q

what are the nutritional requirements for heterotrophic bacteria?

A

requires organic matter like glucose, carbon source, and oxidative phosphorylation

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7
Q

minimal defined and undefined media is for ?

A

clinic (diagnosis) and research

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8
Q

what is glycocalyx?

A

capsules and biofilms
capsules used for antiphagocytosis
biofilms and slime used for immune surveillance and antibiotic resistance by preventing it from penetrating

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9
Q

what are important virulent factors?

A

capsules

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10
Q

what are nucleoids?

A

(in prokaryotes where all genetic material is contained)
double stranded circular DNA molecule
not bounded by membranes
bacterial chromosomes are condensed into supercoiled loop domains

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11
Q

what are plasmids?

A

autonomously replicating circular DNA
antibiotic resistance, produces toxins
takes effect by bacterial conjugation

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12
Q

what are ribosomes?

A

synthesizes proteins
are large, 80 protein - RNA complexes
prokaryotic ribosomes are smaller than eukaryotic ribosomes and are sensitive to antibiotics that do not affect eukaryotic ribosomes

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13
Q

which factors influence bacterial growth?

A

pH- (acidophiles, neutrophiles, or alkaliphiles)
atmosphere- (anaerobes, aerobes, or facultative anaerobes)
Temperature - (flora of human body)
Osmolarity - (halophilic - high [salt] or osmophilic- high osmotic pressure)

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14
Q

what is the growth rate of TB?

what is the growth rate of pseudomonas?

A

TB is slow growing 12 hours doubling time

Pseudomonas is fast growing 20 min doubling time

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15
Q

why is it good to be a non-enveloped virus?

A

because No drying! resistant to drying

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16
Q

what are the 3 mechanisms in bacteria for genetic variability?

A

conjugation - cell to cell contact to transfer genes
transformation - uptake of DNA from medium
transduction - bacteriophage mediated gene transfer

17
Q

why are endospores a virulence factor?

A

because they are heat resistant due to Ca-dipicolinate

18
Q

Transposons

A

are “jumping genes” that can move within or between genomes

19
Q

what are the two mechanisms of genetic variability?

which is important for pathogenesis and antibiotic resistance

A

mutagenesis - heritable change in nucleic acid sequence

Horizontal gene transfer - transfer of genetic material btw organisms of same or different species

20
Q

whats sepsis?

A

hosts response to gram negative LPS (Lipid A)

21
Q

what is bacteremia caused by sepsis?

A

bacteria in the blood stream