B8-049 CBCL Adult Incontinence Flashcards
involuntary leakage on exertion/physical activity, or on sneezing/coughing
stress urinary incontinence (SUI)
involuntary leakage associated with urgency
urge urinary incontinence (UUI)
involuntary leakage associated with urgency and with exertion
mixed urinary incontinence (MUI)
involuntary leakage associated with incomplete bladder emptying
overflow urinary incontinence
incontinence related to underlying neurologic disease
neurogenic urinary incontinence
incontinence unrelated to bladder (i.e. mobility, cognitive, etc)
functional urinary incontinence
[sympathetic/parasympathetic]
Hypogastric nerve, T10-L2
sympathetic
[sympathetic/parasympathetic]
pelvic nerves, S2,3, 4
parasympathetic
[sympathetic/parasympathetic]
release NE in the detrusor muscle to promote bladder relaxation
sympathetic
originates in Onuf’s nucleus in the sacral spinal cord
pudendal nerve
increases tone of the external sphincter to prevent urine leakage while filling
pudendal nerve
[sympathetic/parasympathetic]
release ACh on M2 and M3 receptors to contract the detrusor muscle
parasympathetics
[sympathetic/parasympathetic]
relaxation of the bladder
sympathetic
[sympathetic/parasympathetic]
contraction of bladder outlet
sympathetic
[sympathetic/parasympathetic]
storage
sympathetic
[sympathetic/parasympathetic]
emptying
parasympathetic
[sympathetic/parasympathetic]
detrusor contraction
parasympathetic
[sympathetic/parasympathetic]
urethral relaxation
parasympathetic
why do babies have spontaneous bladder voiding?
lack of guarding reflex
afferent signals inhibit parasympathetic and increase sympathetic activity
guarding reflex
(absent in bebès)
during the filling/storage phase, the bladder accomodates increased volume at low pressure via inhibition of […] system
parasympathetic
(sympathetic and somatic activity)
spinal reflex pathway that activates the sympathetic and somatic nerve pathways
guarding reflex
what keeps the bladder outlet closed during the filing stage?
guarding reflex
when ready to empty, the PAG activates the […] which causes micturition via parasympathetic pathways
PMC
what type of incontinence is generally seen in women, but can be seen in men after prostate surgery?
stress incontinence
what type of incontinence is “overactive bladder” syndrome?
urgency
[what type of incontinence]
sensation of abdominal fullness
dribbling of urine
intermittent stream
overflow
reversible causes of urinary incontinence
Delirium, dementia
Infection
Atrophic vaginitis
Psychosocial (depression)
Pharmacological
Endocrine disorders
Restricted mobility
Stool impaction
DIAPPERS
what is the most accurate way of measuring post void residual?
straight cath
what is considered normal for post void residual?
less than 50 cc is normal
greater than 200 cc is too high
greater than […] RBCs/hpf should prompt urology referral for hematuria
3
[male/female] incontinence should prompt urology referral
male
initial treatment options for UUI/SUI
behavioral modifications
absorbent products
men with overflow incontinence can be treated with
alpha blocker
treatment for overflow incontinence
catheterization
urologic eval to determine if obstructive vs inactive detrusor
medication options for UUI
anticholinergics
b3 agonists
antimuscarinic selective for M3
darifenacin
most common non-selective for M3 antimuscarinic medication
oxybutynin
MOA of mirabegron
b3 agonist
(stimulates b3 receptors in the detrusor muscle to inhibit contraction)
patients with neurogenic incontinence due to suprapontine lesions will have predominately […] symptoms
storage
patients with neurogenic incontinence due to suprapontine lesions will have detrusor […]
overactivity
but normal sphincter activity
patients with neurogenic incontinence due to suprapontine lesions will have […] PVR
normal
patients with neurogenic incontinence due to infrapontine-suprasacral lesions will have […] symptoms
both storage and voiding
patients with neurogenic incontinence due to infrapontine-suprasacral lesions will have […] PVR
increased
patients with neurogenic incontinence due to infrapontine-suprasacral lesions will have detrusor […]
overactivity
and detrusor-spinchter dysenergia
(bladder contracts against high tone outlet)
patients with neurogenic incontinence due to sacral/infrasacral lesions will have […] symptoms
voiding
patients with neurogenic incontinence due to sacral/infrasacral lesions will have […] PVR
increased
patients with neurogenic incontinence due to sacral/infrasacral lesions will have […] detrusor
hypo or acontractile
for cortical lesions,
bladder tone will be […]
sphincter tone will be […]
for cortical lesions,
bladder tone will be [spastic]
sphincter tone will be [normal]
for suprasacral lesions,
bladder tone will be […]
sphincter tone will be […]
for suprasacral lesions,
bladder tone will be [spastic]
sphincter tone will be [spastic]
for sacral lesions,
bladder tone will be […]
sphincter tone will be […]
for sacral lesions,
bladder tone will be [flaccid]
sphincter tone will be [flaccid]
for peripheral lesions,
bladder tone will be […]
sphincter tone will be […]
for peripheral lesions,
bladder tone will be [spastic or flaccid]
sphincter tone will be [normal]
autonomic dysreflexia occurs in patients with SCI above […]
T6
what causes autonomic dysreflexia?
noxious stimuli below level of injury
bladder/bowel distension, UTI, ulcers, etc.
symptoms of autonomic dysreflexia
HA
AMS
flushing
signs of autonomic dysreflexia
hypertension (40 mmHg above resting)
bradycardia
does asymptomatic bacteriuria require treatment?
no
unless pregnancy, or upcoming bladder surgery
urine production at night [increases/decreases] with age
increases
[…]% of the adult population experiences urinary incontinence
15-30
urinary frequency, dysuria, and nocturia are […] voiding symptoms
irritative
hesitancy, straining to void, slow stream, incomplete emptying are […] voiding symptoms
obstructive
antimuscarinic medications act by blocking receptor binding of
ACh
(blocks smooth muscle contraction)
a-blockers act by relaxing the smooth muscle of the […]
prostatic urethra
onobotulinum injections act by blocking
presynaptic release of ACh
(decreases overactive bladder)
stimulation of ACh receptors leads to smooth muscle […]
contraction
caffeine intake is associated with […] incontinence
urgency
one of the most common causes of transient urinary incontinence
UTIs
injury at the level of the sacrum would be associated with […] bladder detrusor and […] urethral sphincter
flaccid
flaccid
[…] should be stopped preopervatiely to eye surgery, as it is associated with floppy iris syndrome
tamsulosin
which nerves are activated in the “storage” phase?
sympathetic and somatic
micturition is activated through the […] in the sacral spinal cord
parasympathetics
what type of incontinence is often caused by intrinsic sphincter deficiency?
stress
most common clinical signs of autonomic dysreflexia [2]
hypertension
bradycardia
common causes of autonomic dysreflexia
bowel/bladder distension
common cause of nocturia in younger patients
undiagnosed diabetes
mirabegron causes detrusor muscle […]
relaxation
what tests are indicated in patients with urinary retention and progressive voiding symptoms?
evaluation of upper tract via renal US and creatinine
cortical brain lesions are most often associated with […] bladder detrusor and […] urethral sphincter function
spastic
normal
a […] should be performed in all patients as a standard part of the evaluation of urinary incontinence
urinalysis
evaluation for hematuria would include what tests?
abdominal/pelvic CT
cystoscopy
first line therapy for post-prostatectomy stress incontinence
physical therapy with biofeedback training
onabotulinum toxin is used to treat […] incontinence
urgency
(treats overactive detrusor)
regulates involuntary bladder function via coordination of the sympathetic and parasympathetics
pontine micturition center
increased sympathetic tone leads to increased urinary […]
retention
increased parasympathetic tone leads to increased urinary […]
voiding
muscarinic antagonists (oxybutynin) inhibit the […] receptor
M3
–> relaxation of detrusor –> decrease detrusor activity
sympathomimetics (mirabegron) activate the […] receptor
B3
–> relaxation of detrusor –> increase badder capacity
what class of medications causes relaxation of smooth muscle in the bladder neck/prostate?
a-1 blockers (tamsulosin)