B7.065 Post CBCL Cognitive Problems

Question 1

cognitive domains

Answer 1

memory
executive function
language
complex attention
perceptual-motor (praxia)
social-cognition

Question 2

subcortical dementia motor signs

Answer 2

rigidity, hyperreflexia, weakness, incoordination

Question 3

cortical dementias

Answer 3

alzheimers

frontotemporal (anterior cortex first) (uncommon)

Question 4

subcortical dementias

Answer 4

vascular

lewy body

Question 5

risk factors for small vessel (lacunar) disease

Answer 5

age
HTN
DM
hyperlipidemia
smoking

Question 6

lacunar syndromes

Answer 6

pure motor hemiparesis
ataxia-hemiparesis
dysarthria-clumsy hand
pure sensory

Question 7

pure motor hemiparesis localization

Answer 7

posterior IC

basilar pons

Question 8

ataxia-hemiparesis localization

Answer 8

internal capsule

basilar pons

Question 9

dysarthria-clumsy hand localization

Answer 9

anterior limb of IC

basilar pons

Question 10

pure sensory localization

Answer 10

thalamus

Question 11

2 types of vascular dementia

Answer 11

1. history of clinical strokes correlated with onset of cognitive deficits
2. no history of clinical strokes but diffuse subcortical vascular disease on imaging

Question 12

AD risk factors

Answer 12

old age
genetics
low education
history of TBI
cardiovascular

Question 13

genetic factors associated with AD

Answer 13

later onset
-apoE4 on ch19
early onset
-presenilin 1 (ch 14)
-presenilin 2 (ch1)
-APP (ch 21)

Question 14

early cognitive changes in AD

Answer 14

short term memory loss
limbic area
first signs in hippocampus

Question 15

FGD PET findings in AD

Answer 15

parietal/temporal decrease in metabolism

Question 16

central acting cholinesterase inhibitors

Answer 16

tacrine
donepezil
galantamine
rivastigmine

Question 17

NMDA receptor antagonist

Answer 17

memantine