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M&M Test 4 > B6-024 Inflammatory Skin Pathology > Flashcards

B6-024 Inflammatory Skin Pathology Flashcards

1
Q

epidermal inflammatory diseases [5]

A

psoriasis
eczema
lupus erythematosus
lichen planus
erythema multiforme

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2
Q

beefy red plaques with silvery scales
tend to be around:scalp, knees, elbows, sacrum, and genitals

A

psoriasis

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3
Q
A

psoriasis

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4
Q

caused by contact with external allergen

A

allergic contact eczema

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5
Q

linear streaks of eczema can be a clue to […] derived allergic contact eczema

A

plant

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6
Q

endogenous reaction to relatively minor allergens often occurring in infancy

A

atopic eczema

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7
Q

lichenification indicates

A

chronic atopic eczema

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8
Q
A

acute eczema

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9
Q

anti-DNA antibodies
+ ANA

A

lupus erythematosis

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10
Q

butterfly malar erythema
no rash in areas protected by sunlight

A

lupus erythematosis

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11
Q

dead reds
melanin drop-out

A

lupus erythematosis

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12
Q

pruritic
purple
polygonal papules

A

lichen planus

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13
Q

Wickham striae in buccal mucosa
often a symmetric distribution

A

lichen planus

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14
Q

Hepatitis C is associated with

A

lichen planus

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15
Q
A

lichen planus

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16
Q

acute eruption
often occurs with HSV, mycoplasma

A

erythema multiforme

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17
Q

target lesions

A

erythema multiforme

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18
Q

normal corneum

A

erythema multiforme

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19
Q

blistering skin diseases [3]

A

pemphigus vulgaris
bullous pemphigoid
dermatitis herpetiformis

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20
Q

cutaneous erosions/oral ulcers of upper trunk/head
painful not itchy

A

pemphigus vulgaris

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21
Q

positive Nikolsky sign

(top layer of skin shears off when rubbed)

A

pemphigus vulgaris

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22
Q
A

pemphigus vulgaris

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23
Q

chicken wire pattern of IgG deposition in lower epidermis

A

pemphigus vulgaris

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24
Q

desmoglein 3

A

pemphigus vulgaris

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25
Q

pemphigus vulgaris is a […] hypersensitivity reaction

A

type II

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26
Q

tense blisters and vesicles on lower abdominal, thighs, forearms
severe pruritus

A

bullous pemphigoid

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27
Q

negative nikolsky sign

A

bullous pemphigoid

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28
Q

what should be on your differential in an elderly patient with severe itching without obvious cause?

A

bullous pemphigoid

**can form urticarial plaques

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29
Q

occurs where epidermis meets dermis
eosinophils

A

bullous pemphigoid

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30
Q

linear deposition of IgG and C3

A

bullous pemphigoid

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31
Q

BPAG1/BPAG2 on hemidesmosomes

A

bullous pemphigoid

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32
Q

bullous pemphigoid is a type […] hypersensitivity reaction

A

2

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33
Q

grouped pruritic papules at nape of neck, knees, elbows, sacrum, scalp

A

dermatitis herpetiformis

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34
Q

associated with HLA-DQ2 and DQ8

A

dermatitis herpetiformis

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35
Q

> 90% of patients have celiac disease

A

dermatitis herpetiformis

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36
Q

dermatitis herpetiformis is treated with [2]

A

dapsone
gluten free diet

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37
Q
A

dermatitis herpetiformis

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38
Q

granular deposition of IgA within dermal papillae

A

dermatitis herpetiformis

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39
Q

IgA complexes with gliadin and transgluatminase

A

dermatitis herpetiformis

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40
Q

dermatitis herpetiformis is a type […] hypersensitivity reaction

A

3

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41
Q

dermal/SQ inflammatory disease [5]

A

acne
rosacea
urticaria
leukocytoclastic vasculitis
erythema nodosum

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42
Q

papules, pustules, nodules, or comedones on face/back/chest
follicular occlusion by keratin debris

A

acne vulgaris

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43
Q

related to increased sebum production

A

acne vulgaris

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44
Q
A

acne vulgaris

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45
Q

redness and dilated blood vessels on nose, cheeks, forehead, chin
gritty sensation in eyes
telangiectasias on biopsy

A

rosacea

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46
Q

transient plaques, annular (ring shaped)
pruritic and edematous

A

urticaria

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47
Q

urticaria is a type […] hypersensitivity reaction

A

1

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48
Q

treatment for urticaria

A

antihistamines

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49
Q

palpable purpura in lower extremities/pressure points

A

leukocytoclastic vasculitis

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50
Q

leukocytoclastic vasculitis is a type […] hypersensitivity reaction

A

3

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51
Q

what additional test should you order for leukocytoclastic vasculitis?

A

UA

**can have kidney involvement

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52
Q
A

leukocytoclastic vasculitis

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53
Q

tender nodules on the shins of young women

A

erythema nodosum

54
Q

erythema nodosum is a type […] hypersensitivity reaction

A

4

55
Q
A

erythema nodosum

56
Q

keratotic papules commonly seen on the hands, feet, face of kids/young adults

A

verruca vulgaris

57
Q

associated with human papillomavirus

A

verruca vulgaris

58
Q

“halo cell” koilocyte

A

verruca vulgaris

59
Q

umbilicated papules on face, neck, axillae, trunk, thighs, buttocks, genitalia seen in children, YA, and HIV+ patient

A

molluscum contagiosum

60
Q

due to direct transmission of a pox virus

A

molluscum contagiosum

61
Q
A

molluscum contagiosum

62
Q

erosions/vesicles with honey colored crusts on the faces/extremities of kids/YA

A

impetigo

63
Q

crusted lesions often caused by S. aureus or S. pyogenes

A

impetigo

64
Q

patients with impetigo caused by S. pyogenes can develop

A

poststreptococcal glomerulonephritis

65
Q
A

impetigo

66
Q

commonly caused by trichophyton rubrum

A

tinea

67
Q

annular plaques with pustules, active border
can be found on scalp, foot, body, toenails, or groin

A

tinea

68
Q
A

tinea

69
Q

papules, nodules, necrosis occurring at sites of trauma, often in immunocompromised patients
can disseminate from lung infection

A

aspergillosis

70
Q

treatment of aspergilloisis

A

systemic antifungals STAT and surgical debridement

**very high mortality rate in disseminated disease

71
Q
A

aspergillosis

72
Q

epidermal vesicles with deep inflammation

A

insect bite

73
Q

pruritic papules classically in the finger webs
worsening itchiness at night

A

scabies

74
Q
A

scabies

75
Q

linear IgA deposition

A

dermatitis herpetiformis

76
Q

dermatitis herpetiformis is a type […] hypersensitivity

A

III

77
Q

treatment for dermatitis herpetiformis [2]

A

dapsone
gluten free diet

78
Q

beefy red plaques with silvery scale

A

psoriasis

79
Q

test tube acanthosis
neutrophils in the stratum corneum

A

psoriasis

80
Q

itchy lesions in web spaces, especially at night

A

scabies

81
Q

treatment for scabies

A

topical permethrin

82
Q

bilateral palpable purpura usually in lower extremity

A

leukocytoclastic vasculitis

83
Q

check a UA if diagnosis is

A

leukocytoclastic vasculitis

84
Q

septate with acute angle branching with blue cytoplasm

A

aspergillosis

85
Q

deep fungal infections typically occur in […] patients

A

immunocompromised

86
Q

tense blisters with negative Nikolskys

A

bullous pemphigoid

87
Q

subepidermal blister with eosinophils, linear C3, and IgG

A

bullous pemphigoid

88
Q

autoantibodies to hemidesmosomes
BP180 antibodies

A

bullous pemphigoid

89
Q

red scaly plaques, dyspigmentation, scarring in a photodistribution

A

lupus erythematosus

90
Q

carpet tack scale
smudged DEJ
deep inflammation

A

lupus erythematosus

91
Q

grouped papules
across nape of neck, knees, lower back, elbows

A

dermatitis herpetiformis

92
Q

pruritic papules at ankles and wrists

A

lichen planus

93
Q

linear papules at hands, nipples, waistline, and genitalia

A

scabies

94
Q

scaly, annular, pustular rash

A

tinea

95
Q

blisters caused by suprabasal acanthylosis

A

pemphigus vulgaris

96
Q

subepidermal blisters

A

bullous pemphigus

97
Q

dermatitis with squamatization, hypergranulosis, and orthokeratosis

A

lichen planus

98
Q

band like infiltrate of lymphocytes at DEJ
saw tooth pattern squamatized epidermal hyperplasia
wedge-shaped hypergranulosis

A

lichen planus

99
Q

neutrophils in tips of papillae without parakeratosis

A

dermatitis herpetiformis

100
Q

spongiosis

A

eczema

101
Q

scabies is caused by

A

sarcoptes scabei

102
Q

gram positive bacteria producing lipase which forms irritating fatty acids within occluded hair follicles

A

propionibacterium

103
Q

bacteria causing acne vulgaris

A

propionibacterium

104
Q

treatment for acne vulgars

A

benzoyl peroxide

doxycyline if refractory

105
Q

causes deep, potentially fatal infections in immunocompromised patients
manifests with necrotizing papules and plaques

A

aspergillus

106
Q

genus of mites that infect the skin and produce itching that is worse at night

A

sarcoptes

107
Q

linear burrows across finger webs and genitalia

A

scabies

108
Q

genus of fungi that produce tinea

A

trichophyton

109
Q

annular scaling rashes with pustules

A

trichophyton

110
Q

umbilicated papules without comedones

A

molluscum

111
Q

type […] hypersensitivity reactions are mediated by antibodies

A

II

112
Q

type […] hypersensitivity reactions are mediated by antigen-antibody complexes

A

III

113
Q

type […] hypersensitivity reactions are cell-mediated responses independent of antibodies

A

IV

114
Q

type […] hypersensitivity reactions occur when antibodies bind to cell surface receptors

A

V

**graves disease

115
Q

type […] hypersensitivity reactions are mediated by mast cells and IgE

A

I

116
Q

allergic rhinitis is associated with

A

atopic dermatitis

117
Q

inflammatory arthritis is associated with

A

psoriasis

118
Q

sarcoidosis is associated with

A

erythema nodosum

119
Q

every patient with leukocytoclastic vasculitis should have a urianalysis to evaluate for

A

renal failure

120
Q

IgG and C3 deposits between keratinocytes in “fishnet” pattern

A

pemphigus vulgaris

121
Q

granular IgA deposits

A

dematitis herpetiformis

122
Q

linear deposits of IgG in basement membrane

A

bullous pemphigoid

123
Q

beefy red plaques with silver scales

A

psoriasis

124
Q

ill-defined erythematous plaques which ooze, crust, scale, and itch

A

eczema

125
Q

target lesions with “bullseye” appearance and no scale

A

erythema multiforme

126
Q

pruritic violaceous polygonal papules and Wichham’s striae

A

lichen planus

127
Q

butterfly malar rash

A

acute SLE

128
Q

dispigmented plaques and “carpet tack” scales

A

discoid SLE

129
Q

patients with severe muco-cutaneous erythema multiforme may have

A

mycoplasma pneumonia

130
Q

all hospitalized patients with erythema multiforme should be tested for

A

IgG and IgM to mycoplasma pneumoniae

131
Q

anti-transglutaminase antibodies are seen in

A

dermatitis herpetiformis

132
Q

mucocutaneous rash
acanthylosis
intraepidermal blistering with tombstone basal keratinocytes

A

pemphigus vulgaris

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