B Cell ALL t(12;21)

Question 1

What does the t(12;21) cause?

Answer 1

TEL-AML1….Inhibits differentiation

Question 2

Prognosis?

Answer 2

Good 90%

Question 3

WHo is affected?

Answer 3

Kids 25% of all pediatric ALL

Question 4

What type of mutation does the t(12;21) fusion cause?

Answer 4

Pax5 gene mutation…leads to lack of differentiation

Question 5

Immunophenotype

Answer 5

TdT, Cd34

Question 6

Treat with ?

Answer 6

PVA (Prednisone, vincristine, anthracycline)