B / 34 : Drugs Used In Cancer Treatment VI (Large Molecule Signal Transduction Inhibitors) Flashcards
1
Q
Trastuzumab
- MOA
- Indication
- SE
A
- Anti-HER2 antibody : humanized monoclonal AB
- For metastatic breast cancer + gastric adenocarcinoma
- Injection site reaction, cardiotoxicity
2
Q
What are the large molecule signal transduction inhibitors?
A
- Trastuzumab
- Panitumumab
- Rituximab
- Bevacizumab
3
Q
Panitumumab
- MOA
- Indication
- SE
A
- Anti-EGFR antibody : human monoclonal AB
- For colorectal cancer, squamous cell carcinoma
- CNS, rash
4
Q
Rituximab
- MOA
- Effect
- Indication
- SE
A
- Anti-CD20 AB, chimeric monoclonal AB
- Induces complement mediated lysis - induces apoptosis and reduces B cell count
- CLL, non-Hodgkin lymphoma, RA
- Infusion reaction, HBV reactivation
5
Q
Bevacizumab
- MOA
- Effect
- Indication
- SE
A
- Anti VEGF inhibitor AB, humanized monoclonal
- Binds and neutralizes VEGF
- For colon, breast, lung cancer
- Hypertension, GI perforations, wound healing complications
6
Q
What are the 3 immunostimulant anticancer drugs?
A
- Aldesleukin
- Interferon alpha
- Pembrolizumab
7
Q
Aldesleukin
- MOA
- Effect
- Indication
- SE
A
- IL-2 recombinant protein
- Stimulates growth + differenciation of T and B cells
- For melanoma, renal cancer
- Hypotension, edema, tachycardia
8
Q
Interferon alpha
- Effect
- Induction
- SE
A
- Antineoplastic, antiviral + immunosuppressive properties
- For melanoma, hairy cell leukemia, Kaposi sarcoma
- CNS, GI symptoms + BM suppression
9
Q
Pembrolizumab
- MOA
- Effect
- Indication
- SE
A
- Humanized monoclonal AB, immune checkpoint inhibitor
- Binds lymphocyte and activates T cells
- For melanoma, NSCLC
- Injection site reaction, pneumonitis
