B / 32 : Drugs Used In Cancer Treatment Iv (Hormonal Agents)

Question 1

When can hormone therapy be used in cancer?

Answer 1

For hormone dependent cancers, for example : prostate cancer grows faster with more testosterone

Question 2

What are the anti-estrogen drugs?

Answer 2

Tamoxifen

Question 3

Tamoxifen
- MOA
- Effect
- Indication
- SE
- ROA

Answer 3

• Estrogen receptor ANTagonist in BREAST, AGonist in ENDOMETRIUM, partial AGonist in bones
• For treatment of breast cancer + prevention after surgery
• Hot flashes, hyperplasia, polyps, increased risk of endometrial cancer
• Oral

Question 4

What is an example of an aromatase inhibitor?

Answer 4

Anastrozole

Question 5

What are the types of hormonal agents used in cancer treatment? (5)

Answer 5

• Anti estrogens
• Aromatase inhibitors
• LH analogs
• Anti-androgens
• Glucocorticoids + somatostatin analogs

Question 6

Anastrozole
- MOA
- Effect
- Indication
- SE
- ROA

Answer 6

• Aromatase (non steroidal) inhibitor
• Prevents conversion of testosterone to estrogen
• For treatment of hormone dependent breast cancer in post menopausal women
• Hot flashes, vaginal dryness, risk of osteoporosis and cardiovascular diseases
• Oralé

Question 7

What is the role of the aromatase enzyme?

Answer 7

Conversion of testosterone to estrogen

Question 8

What are the LH analogs?

Answer 8

• Goserelin
• Degarelix

Question 9

Goserelin
- MOA
- Effect
- Indication
- SE
- ROA

Answer 9

• Synthetic peptide with GnRH AGonist activity
• Depends on the dose
• Pulsatile : for induction of ovulation / Continuous : endometriosis, tumors
• Women : vaginal dryness, breast atrophy / men : edema, anemia
• Parenteral

Question 10

Degarelix
- MOA
- Effect
- Indication
- ROA

Answer 10

• GnRH ANTagonist
• Suppress endogenous LH and FSH
• Prostate cancer
• Parenteral

Question 11

What is an example of an anti-androgen

Answer 11

BIcalutamide

Question 12

Bicalutamide
- MOA
- Effect
- Indication
- SE
- ROA

Answer 12

• Androgen receptor inhibitor
• Decreases testosterone
• For prostate cancer
• Gonadal atrophy, gynecomastia, infertility
• Oral

Question 13

What are the glucocorticoid / somatostatin analogs?

Answer 13

• Prednisolone (glucocorticoids)
• Ocreotide (somatostatin)

Question 14

Prednisolone
- MOA
- Effect
- Indication
- ROA

Answer 14

• Glucocorticoid analog
• Alter gene expression + anti-inflammatory and immunosuppressive effects
• For Hodgkin and non Hodgkin lymphomas, acute leukemias
• Oral, Topical, IV

Question 15

Ocreotide
- MOA
- Effect
- Indication
- SE
- ROA

Answer 15

• Somatostatin analog
• Inhibit release of GH, insulin, glucagon, gastrin : decrease GI function
• For endocrine tumors
• GI, steatorrhea
• Parenteral